The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

Wang, Yi; Zheng, Yu; Liu, Yi; Shan, Guo-Shun; Zhang, Baojie; Cai, Qian; Lou, Jiayue; Yang, Qing

doi:10.3389/fnut.2023.1149094

Cited by 4 publications

(2 citation statements)

References 105 publications

(125 reference statements)

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“…Intestinal bile acids mediate intestinal absorption of lipids ( Hu et al, 2023b ). A recent study found that fecal bile acid excretion was positively associated with lower blood lipids ( Wang et al, 2023 ). Bile acids simultaneously affect microbial survival and colonization by promoting lipid absorption ( Wu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Inulin ameliorates metabolic syndrome in high-fat diet-fed mice by regulating gut microbiota and bile acid excretion

Huang¹,

Dong²,

Lin³

et al. 2023

Front. Pharmacol.

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Background: Inulin is a natural plant extract that improves metabolic syndrome by modulating the gut microbiota. Changes in the gut microbiota may affect intestinal bile acids. We suggest that inulin may improve metabolism by inducing bile acid excretion by gut microbes.Methods: Male C57/BL mice were fed either a high-fat diet (60% calories) or a regular diet for 16 weeks, with oral inulin (10% w/w). At the end of the experiment, the gene expression levels (FGF15, CD36, Srebp-1c, FASN, and ACC) in the liver and intestines, as well as the serum levels of triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, total cholesterol, and free fatty acids, were collected. The expression of FGF15 was examined using Western blot analysis. The fat distribution in the liver and groin was detected by oil red and hematoxylin and eosin staining. Simultaneously, the levels of serum inflammatory factors (alanine aminotransferase and aspartate aminotransferase) were detected to explore the side effects of inulin.Results: Inulin significantly improved glucose tolerance and insulin sensitivity, and decreased body weight and serum TG and LDL levels, in mice fed normal diet. Furthermore, inulin increased the α-diversity of the gut microbiota and increased the fecal bile acid and TG excretion in inulin-treated mice. In addition, inulin significantly reduced lipid accumulation in liver and inguinal fat, white fat weight, and hepatic steatosis. Western blot analysis showed that inulin reduced the expression of FGF15, a bile acid reabsorption protein.Conclusion: Inulin ameliorates the glucose and lipid metabolic phenotypes of mice fed a normal diet, including decreased intestinal lipid absorption, increased glucose tolerance, increased insulin sensitivity, and decreased body weight. These changes may be caused by an increase in bile acid excretion resulting from changes in the gut microbiota that affect intestinal lipid absorption.

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Section: Discussionmentioning

confidence: 99%

Inulin ameliorates metabolic syndrome in high-fat diet-fed mice by regulating gut microbiota and bile acid excretion

Huang¹,

Dong²,

Lin³

et al. 2023

Front. Pharmacol.

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“…Moreover, the soluble fiber in fenugreek seeds binds to cholesterol molecules in the gut, preventing their absorption into the bloodstream, and has been shown to lower total cholesterol and LDL (low‐density lipoprotein) cholesterol levels, reducing the risk of heart disease (Wang et al., 2023 ). Fenugreek seeds have been shown to hold appetite‐suppressing properties and can help control hunger and reduce food intake.…”

Section: Introductionmentioning

confidence: 99%

The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications

Faisal,

Irfan,

Akram

et al. 2024

Food Science & Nutrition

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The present lifestyle, dietary patterns, psychological pressure, environmental factors, and the widespread exploitation of processed substances in food production and farming have collectively contributed to a substantial expediting in the development of various health problems. Globally, researchers have been seeking natural pharmaceutical substances with the potential to be employed in treating lifestyle‐related diseases or delaying their onset. Fenugreek seeds have gained significant attention in various fields, including health, nutrition, and cutting‐edge nanotechnology applications, due to their versatile qualities. The current investigation offers a comprehensive discussion of the nutritional composition and therapeutic potential of fenugreek seeds, with an emphasis on their plentiful reservoir of bioactive compounds. This seed demonstrates promising medicinal potential in addressing a wide range of health issues. Significantly, these findings indicate noteworthy properties, such as antidiabetic, antioxidant, anti‐obesity, hypocholesterolemic, anticancer, and cardioprotective effects. Moreover, the components of fenugreek seeds are important in the development of a multitude of foods, which is the reason why they are used extensively in the area of food research. In addition to their nutritional value, their exploration of nanotechnology reveals a promising domain, utilizing the distinctive characteristics of seeds for many purposes, such as nanoparticle synthesis and oil for edible films and nanoemulsions. This review article focuses on a comprehensive analysis of fenugreek seeds, examining their wide‐ranging applications in the fields of health, nutrition, food, and nanotechnology.

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The Importance and Scope of Medicinal Plants Suggested in Traditional Medicine in the Holistic Care of Occupational Lifestyle Disorders with Special Mention to Insulin Resistance Associated Clinical Syndromes

Nair,

Dixit

2023

Role of Herbal Medicines

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The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

Cited by 4 publications

References 105 publications

Inulin ameliorates metabolic syndrome in high-fat diet-fed mice by regulating gut microbiota and bile acid excretion

Inulin ameliorates metabolic syndrome in high-fat diet-fed mice by regulating gut microbiota and bile acid excretion

The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications

The Importance and Scope of Medicinal Plants Suggested in Traditional Medicine in the Holistic Care of Occupational Lifestyle Disorders with Special Mention to Insulin Resistance Associated Clinical Syndromes

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