Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic &lt;em&gt;Streptomyces&lt;/em&gt; SUK10

Zin, Noraziah Mohamad; Baba, Mohd Shukri; Zainal-Abidin, A. H.; Latip, Jalifah; Mazlan, Noor Wini; Edrada-Ebel, RuAngelie

doi:10.2147/dddt.s121283

Cited by 37 publications

(25 citation statements)

References 54 publications

(71 reference statements)

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“…Diketopiperazine gancidin W (GW) was isolated from the Streptomyces sp. SUK10, an endophyte from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100 (Zin et al, 2017 ). Kakadumycin A, a quinoxaline antibiotic with broad spectrum activity against Gram-positive bacteria and malaria parasites was reported from endophytic Streptomyces sp.…”

Section: Chemical Diversity and Therapeutic Significance Of Secondarymentioning

confidence: 99%

Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches

2018

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Actinobacteria are wide spread in nature and represent the largest taxonomic group within the domain Bacteria. They are abundant in soil and have been extensively explored for their therapeutic applications. This versatile group of bacteria has adapted to diverse ecological habitats, which has drawn considerable attention of the scientific community in recent times as it has opened up new possibilities for novel metabolites that may help in solving some of the most challenging problems of the day, for example, novel drugs for drug-resistant human pathogens, affordable means to maintain ecological balance in various habitats, and alternative practices for sustainable agriculture. Traditionally, free dwelling soil actinobacteria have been the subject of intensive research. Of late, symbiotic actinobacteria residing as endophytes within the plant tissues have generated immense interest as potential source of novel compounds, which may find applications in medicine, agriculture, and environment. In the light of these possibilities, this review focuses on the diversity of endophytic actinobacteria isolated from the plants of extreme habitats and specific ecological niches. Furthermore, an attempt has been made to assign chemical class to the compounds obtained from endophytic actinobacteria. Potential therapeutic applications of these compounds and the utility of endophytic actinobacteria in agriculture and environment are discussed.

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Section: Chemical Diversity and Therapeutic Significance Of Secondarymentioning

confidence: 99%

Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches

2018

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“…Thus, endophytic actinomycetes associated with traditionally used medicinal plants, especially in the tropics, could be a rich source of functional metabolites (Golinska et al, 2015). In the literature, endophytic actinomycetes associated with medicinal plants have shown the ability to synthesize many valuable bioactive compounds, including anticancer, antiviral, antimicrobial, antifungal and antiparasitic agents (Inahashi et al, 2015;Tanvir et al, 2016;Zhang et al, 2014;Zin et al, 2017). A number of the secondary metabolites are novel in structure and have broad-spectrum bioactivities that could be potentially applicable in the pharmaceutical, medical and agricultural sectors (Golinska et al, 2015;Matsumoto and Takahashi, 2017).…”

Section: Introductionmentioning

confidence: 99%

Endophytic actinomycetes associated with <i>Cinnamomum cassia</i> Presl in Hoa Binh province, Vietnam: Distribution, antimicrobial activity and, genetic features

Nguyen

Dinh

et al. 2020

J. Gen. Appl. Microbiol.

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Endophytic microbes associated with medicinal plants are considered to be potential producers of various bioactive secondary metabolites. The present study investigated the distribution, antimicrobial activity and genetic features of endophytic actinomycetes isolated from the medicinal plant Cinnamomum cassia Presl collected in Hoa Binh province of northern Vietnam. Based on phenotypic characteristics, 111 actinomycetes were isolated from roots, stems and leaves of the host plants by using nine selective media. The isolated actinomycetes were mainly recovered from stems (n = 67; 60.4%), followed by roots (n = 29; 26.1%) and leaves (n = 15; 13.5%). The isolates were accordingly assigned into 5 color categories of aerial mycelium, of which gray is the most dominant (n = 42; 37.8%), followed by white (n = 33; 29.7%), yellow (n = 25; 22,5%), red (n = 8; 7.2%) and green (n = 3; 2.7%). Of the total endophytic actinomycetes tested, 38 strains (occupying 34.2%) showed antimicrobial activity against at least one of nine tested microbes and, among them, 26 actinomycetes (68.4%) revealed anthracycline-like antibiotics production. Analysis of 16S rRNA gene sequences deposited on GenBank (NCBI) of the antibioticproducing actinomycetes identified 3 distinct genera, including Streptomyces, Microbacterium, and Nocardia, among which Streptomyces genus was the most dominant and represented 25 different species. Further genetic investigation of the antibioticproducing actinomycetes found that 28 (73.7%) and 11 (28.9%) strains possessed genes encoding polyketide synthase (pks) and nonribosomal peptide synthetase (nrps), respectively. The findings in the present study highlighted endophytic actinomycetes from C. cassia Presl which possessed

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“…Diketopiperazines are natural cyclic dipeptides produced by microorganisms with a broad range of biological activities such as antimicrobial, anticancer, antiviral, antifungal, antibacterial, and antihyperglycemic [45,46]. Likewise, cyclo(L-Leu-L-Pro) cyclodipeptide (6), a diketopiperazine known as gancidin W, has been reported as potent antimalarial and antimicrobial agent with MIC values between 0.25 and 12.5 μg/mL against Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Candida albicans, and Cryptococcus neoformans [46,47].…”

Section: Resultsmentioning

confidence: 99%

Mycotoxins from Fusarium proliferatum: new inhibitors of papain-like cysteine proteases

et al. 2020

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Papain-like cysteine proteases (PLCPs) in plants are essential to prevent phytopathogen invasion. In order to search for cysteine protease inhibitors and to investigate compounds that could be associated to pineapple Fusarium disease, a chemistry investigation was performed on Fusarium proliferatum isolated from Ananas comosus (pineapple) and cultivated in Czapek medium. From F. proliferatum extracts, nine secondary metabolites were isolated and characterized by nuclear magnetic resonance spectroscopy and mass spectrometry experiments: beauvericin (1), fusaric acid (2), N-ethyl-3-phenylacetamide (3), Nacetyltryptamine (4), cyclo(L-Val-L-Pro) cyclodipeptide (5), cyclo(L-Leu-L-Pro) cyclodipeptide (6), cyclo(L-Leu-L-Pro) diketopiperazine (7), 2,4-dihydroxypyrimidine (8), and 1H-indole-3-carbaldehyde (9). Compounds 1, 3, and 6 showed significant inhibition of papain, with IC 50 values of 25.3 ± 1.9, 39.4 ± 2.5, and 7.4 ± 0.5 μM, respectively. Compound 1 also showed significant inhibition against human cathepsins V and B with IC 50 of 46.0 ± 3.0 and 6.8 ± 0.7 μM, respectively. The inhibition of papain by mycotoxins (fusaric acid and beauvericin) may indicate a mechanism of Fusarium in the roles of infection process.

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Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic <em>Streptomyces</em> SUK10

Cited by 37 publications

References 54 publications

Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches

Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches

Endophytic actinomycetes associated with <i>Cinnamomum cassia</i> Presl in Hoa Binh province, Vietnam: Distribution, antimicrobial activity and, genetic features

Mycotoxins from Fusarium proliferatum: new inhibitors of papain-like cysteine proteases

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