Gamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score

Uçar, Hakan; Gür, Mustafa; Gözükara, Mehmet Yavuz; Kalkan, Gülhan Yüksel; Baykan, Ahmet Oytun; Türkoğlu, Caner; Kaypakl, Onur; Şeker, Taner; Şen, Ömer; Selek, Sahabettın; Çayl, Murat

doi:10.3109/00365513.2014.954141

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…It has been reported that GGT is a marker for oxidative stress and inflammation and positively associated with inflammatory markers including C reactive protein, IL-6 and IL-1β 21. Increased visceral fat is accompanied by increased production of proinflammatory adipokines and cytokines such as IL-6 and Plasminogen activator inhibitor-1 19.…”

Section: Discussionmentioning

confidence: 99%

Visceral fat is associated with elevation of serum alanine aminotransferase and gamma glutamyltransferase in middle-aged Chinese adults

Tang

Yuan

Zhang

et al. 2018

Postgraduate Medical Journal

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Background Elevation of hepatic enzymes is associated with insulin resistance, dyslipidaemia and obesity. However, the factors behind elevation of liver enzymes remain unclear. The aim of this study was to compare the role of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in relation with serum alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) in middle-aged Chinese adults.Methods We performed a cross-sectional study on 959 adults aged 40–65 without hepatitis. VAT and SAT were measured at the level of L4–L5 by MRI. Pearson correlation and linear regression were performed to assess the association of VAT/SAT with serum ALT and GGT. Logistic regression was used to evaluate the association of VAT and SAT with high ALT (≥40 U/L) and high GGT (≥35 U/L).ResultsVAT had higher correlation coefficient r with ALT and GGT than SAT. VAT, but not SAT, was associated with ALT (males: β=0.15, p=0.01; females: β=0.17, p=0.02) and GGT (males: β=0.39, p<0.0001) in linear regression. VAT remained to be associated with GGT in males (β=0.33, p=0.0001) when was further adjusted. Logistic regression showed that VAT was associated with elevated GGT (OR=2.218, p=0.043) in males but not in females and no such association was observed for SAT.ConclusionsIncreased VAT, but not SAT, was associated with elevation of hepatic enzymes including ALT and GGT. Moreover, VAT was associated with elevated GGT independent of insulin resistance and subcutaneous fat in males.

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Section: Discussionmentioning

confidence: 99%

Visceral fat is associated with elevation of serum alanine aminotransferase and gamma glutamyltransferase in middle-aged Chinese adults

Tang

Yuan

Zhang

et al. 2018

Postgraduate Medical Journal

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“…The serum concentration of gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress [2, 3], and oxidative stress has been reported to play a crucial role in the pathogenesis of both of atherosclerosis [4] and hypertension [5]. As aging is also known to be associated with oxidative stress [6, 7], γ-GTP could act as a marker of risk factor in age-related disease such as atherosclerosis and hypertension in elderly subjects.…”

Section: Introductionmentioning

confidence: 99%

Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study

Shimizu

Kawashiri

Kiyoura

et al. 2019

Environ Health Prev Med

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BackgroundEven though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted.MethodsWe conducted a cross-sectional study of 562 elderly Japanese men aged 60–69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension.ResultsIn the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)).Conclusionsγ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.

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“…Serum GGT activity is regarded as an early marker of antioxidant inadequacy, even within the reference range generally accepted [44, 45]. In this study, PDL women have shown a higher GGT activity compared to those from Lisbon, which was correlated with all aminothiols, mainly GSH.…”

Section: Discussionmentioning

confidence: 50%

Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal

Lima

Ferin

Bourbon

et al. 2019

Journal of Nutrition and Metabolism

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In Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal. The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease. The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20–69 years. No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon. Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs. Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs. 6%, P=0.003). Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies.

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Gamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score

Abstract: In stable CAD, increased GGT activity within the normal range is associated with increased oxidative stress rather than increased extent and complexity of CAD.

Cited by 19 publications

References 31 publications

Visceral fat is associated with elevation of serum alanine aminotransferase and gamma glutamyltransferase in middle-aged Chinese adults

Visceral fat is associated with elevation of serum alanine aminotransferase and gamma glutamyltransferase in middle-aged Chinese adults

Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study

Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal

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