Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study

Shimizu, Yūji; Kawashiri, Shin‐ya; Kiyoura, Kairi; Nobusue, Kenichi; Yamanashi, Hirotomo; Nagata, Yasunobu; Maeda, Takahiro

doi:10.1186/s12199-019-0828-2

Cited by 29 publications

(54 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, Model 3 was further adjusted for other potential confounding factors, namely systolic blood pressure (mmHg) (systolic blood pressure was not adjusted for the analysis to determine the association of hypertension on baseline subclinical atherosclerosis and active arterial wall thickening), BMI (kg/m 2 ), alcohol consumption (never drinker, former drinker, or current drinker [23-45 g/week, 46-68 g/week, ≥ 69 g/ week]), HDLc (mg/dL), triglycerides (mg/dL), HbA1c (%), and GFR (mL/min/1.73 m 2 ). Those confounding factors were the same as a previous study that examined CD34+ cells, hypertension, and atherosclerosis 14,35 . We also performed a simple correlation analysis and multiple linear regression analysis of circulating CD34+ cells, with relevant factors adjusted for confounding factors stratified by hypertension status.…”

Section: Discussionmentioning

confidence: 99%

“…An experienced vascular examiner measured both left-and right-sided carotid intima-media thickness (CIMT) of the common carotid arteries using LOGIQ Book XP with a 10-MHz transducer (GE Healthcare, Milwaukee, WI, USA). Active endothelial repair that is associated with atherosclerosis, evaluated using the maximum values of CIMT, could have a beneficial association with hypertension among subjects with high CD34+ cell levels 14 . The present study aimed to clarify the hypertension status-specific association between active arterial wall thickening (active endothelial repair) and CD34+ cell levels.…”

Section: Data Collection and Laboratory Measurementsmentioning

confidence: 99%

“…Since active atherosclerosis (arterial wall thickening) caused by aggressive repair of endothelium might have a beneficial influence on the microcirculation and help prevent hypertension in elderly subjects 14,26,27 , clarifying the underlying mechanism of endothelium repair is an effective way to determine an efficient strategy for preventing age-related disease.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

Shimizu

Kawashiri

Kiyoura

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (the principal mediators of atherosclerosis). Despite this, aggressive endothelial repair (progressing atherosclerosis) might cause a wasting reduction in CD34+ cells, which could result in a lower capacity of endothelial repair and hypertension. As yet, no prospective study has clarified the association of circulating CD34+ cells with active arterial wall thickening. We conducted a prospective study of 363 men aged 60-69 years who participated in a general health checkup at least twice from 2014-2017. The circulating CD34+ cell count was significantly positively associated with active arterial wall thickening among subjects without hypertension (n = 236), but not among subjects with hypertension (n = 127). The fully adjusted odds ratios (ORs) of active arterial wall thickening for the logarithmic circulating CD34+ cell count were 1.83 (1.19, 2.84) and 0.69 (0.36, 1.32) for subjects without and with hypertension, respectively. Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension. this study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects. Recently, bone marrow-derived hematopoietic stem cells (immature cells, such as CD34+ cells) have been revealed to play a major role in vascular homeostasis 1-3. It is likely that the number of circulating CD34+ cells could indicate the capacity of endothelial maintenance 4-6. However, it is known that hematopoietic bone marrow activity declines with age 7-10 , which might induce a lower capacity of endothelial maintenance in elderly subjects. Furthermore, aging is a well-known cause of endothelial injury 11,12 which subsequently induces endothelial repair. In addition, the aggressive endothelial repair that causes atherosclerosis might induce a wasting reduction of circulating CD34+ cells 6,13 which result in a shortage of the mediators of endothelial repair. Moreover, inadequate endothelial repair might cause hypertension in elderly individuals 14. These previous studies indicate that there are close connections among the age-related decline of bone marrow activity, age-related endothelial injury, and the wasting reduction of circulating CD34+ cells. Platelets are also known to play an important role in vascular inflammation and vessel wall remodeling 15,16. Indeed, platelets promote the mobilization of bone marrow-derived CD34+ cells into the peripheral blood 17-21 , and CD34+ cells also induce platelet elevation 22,23. Furthermore, platelets have been reported to play an important role in the initial development of atherosclerotic lesions 24 , and not only induce the differentiation of human CD34+ cells into endothelial cells, but also into foam cells, which contribute to the development of atherosclerosis 25. Therefore, platelets also play an important role in the a...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Data Collection and Laboratory Measurementsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

Shimizu

Kawashiri

Kiyoura

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…GGT correlated positively with atherosclerosis patients who presented an higher number of CD-34 positive cells. In patients with low CD34-positive cells, GGT correlated with hypertension [26].…”

Section: Gamma-glutamyl Transferase and Pathological Processesmentioning

confidence: 92%

Gamma-glutamyl transferase and cardiovascular disease risk

Miricescu¹,

Totan²,

Stănescu³

et al. 2020

Ro Med J.

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) represent a major health problem in adult population worldwide. Together with conventional risk factors, gamma-glutamyl transferase (GGT) is involved in the pathogenesis of CVD. The purpose of this review is to provide informations about GGT synthesis, physiological roles and the involvement in the atherosclerotic plaque formation. The results of the most recent clinical studies performed to find an association between GGT serum activity and patients with hypertension and coronary artery disease (CAD) are presented.

show abstract

“…Important features comprised items related to hypertension, such as age, body composition (leg score, body mass index (BMI), and waist), blood glucose, and gamma glutamyl transferase (g-GTP) [27][28][29][30][31][32][33][34][35] . Therefore, the selected explanatory variables were considered to be reasonable for SBP predictive models from the clinical perspective.…”

Section: Application On Actual Health Checkup Datasetmentioning

confidence: 99%

Health improvement framework for planning actionable treatment process using surrogate Bayesian model

Nakamura

Kojima

Uchino

et al. 2020

Preprint

View full text Add to dashboard Cite

Clinical decision making regarding treatments based on personal characteristics leads to effective health improvements. Machine learning (ML) has been the primary concern of diagnosis support according to comprehensive patient information. However, the remaining prominent issue is the development of objective treatment processes in clinical situations. This study proposes a novel framework to plan treatment processes in a data-driven manner. A key point of the framework is the evaluation of the "actionability" for personal health improvements by using a surrogate Bayesian model in addition to a high-performance nonlinear ML model. We first evaluated the framework from the viewpoint of its methodology using a synthetic dataset. Subsequently, the framework was applied to an actual health checkup dataset comprising data from 3,132 participants, to improve systolic blood pressure values at the individual level. We confirmed that the computed treatment processes are actionable and consistent with clinical knowledge for lowering blood pressure. These results demonstrate that our framework could contribute toward decision making in the medical field, providing clinicians with deeper insights.

show abstract

Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study

Cited by 29 publications

References 30 publications

Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

Gamma-glutamyl transferase and cardiovascular disease risk

Health improvement framework for planning actionable treatment process using surrogate Bayesian model

Contact Info

Product

Resources

About