Visceral fat is associated with elevation of serum alanine aminotransferase and gamma glutamyltransferase in middle-aged Chinese adults

Tang, Lei; Yuan, Bo; Zhang, Fang; Cao, Hongyan; Yan, Zhe; Li, Jing; Jobin, John; Tong, Nanwei

doi:10.1136/postgradmedj-2018-135644

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…association of GGT with WC and not BMI is in keeping with a recent cross-sectional study among Chinese adults [34]. This suggests that visceral adipose tissue, as measured by WC, better correlates with GGT than subcutaneous adipose tissue; the latter identified by BMI and representing general adiposity.…”

Section: Plos Onesupporting

confidence: 88%

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa

2021

View full text Add to dashboard Cite

Background Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV. Methods In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, metabolic syndrome by Joint Interim Statement criteria (JIS-MS), a ≥5% and ≥10% predicted risk for a CVD event within 10 years by the Framingham risk score (10-years-CVD risk) were computed. Associations between GGT and cardio-metabolic trait were explored using linear and binomial logistic regressions adjusted for age, gender, lifestyle behaviours and HIV-related characteristics. Results Among 709 participants (561 women, mean age 38.6 years), log-GGT was positively associated with waist circumference (β=2.75; p<0.001), diastolic blood pressure (β=1.65; p=0.006), total cholesterol (β=0.21; p<0.001), low-density lipoprotein-cholesterol (β=0.16; p<0.001), high-density lipoprotein-cholesterol and log-triglycerides (both β=0.12; p<0.001), fasting plasma glucose (β=0.19; p=0.031), 2-hour-post-glucose-load plasma glucose (β=0.26; p=0.007), HOMA-IR (β=0.13; p=0.001), log-high-sensitivity C-reactive-protein (β=0.3; p<0.001) in linear regression analyses; with hypertension [OR=1.41 (95%CI, 1.13-1.75); p=0.001], JIS-MS [OR=1.33 (1.05-1.68); p=0.016], ≥5% 10-year-CVD risk [OR=1.55 (1.24-1.9400); p<0.001] and ≥10% 10-year-CVD risk [OR=1.56 (1.08-2.23); p=0.016] but not with diabetes [OR=1.24 (0.88-1.71), p=0.205] in logistic regression analyses. Conclusions In this study, GGT levels were associated with cardio-metabolic variables independent of HIV specific attributes. If confirmed in longitudinal studies, GGT evaluation maybe included in CVD risk monitoring strategies in people living with HIV.

show abstract

Section: Plos Onesupporting

confidence: 88%

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa

2021

View full text Add to dashboard Cite

show abstract

“…Among hepatitis-positive donors (400 HBV positive and 67 HCV positive), only 0.75% (3/400) of HBV-positive donors and 13.43% (9/67) of HCV-positive donors had elevated ALT levels (Table 2). These results suggest that ALT testing adds little risk reduction value for transfusiontransmitted diseases, which is in line with results from previous studies in other countries [21][22][23][24] . During the 7year observation period, 10.76% (291 donations) of excluded blood were discarded only due to high ALT levels.…”

Section: Discussionsupporting

confidence: 91%

Significance of alanine aminotransferase testing in blood donor screening in Chongqing, China: a 7-year retrospective analysis

Song,

Xue,

Fan

et al. 2023

Blood&Genomics

View full text Add to dashboard Cite

Since 1993, alanine aminotransferase (ALT) testing has been mandatory for blood donor screening in China. This study aimed to evaluate the significance of ALT testing for transfusion safety. Between January 2012 and December 2018, 122 236 blood donor samples were routinely screened by the enzyme-linked immunosorbent assay method for transfusion-transmitted disease markers (TTDM) and by the kinetics method for ALT. Out of 2705 (2.21%) seropositive donors, 291 (10.76%) tested positive for ALT alone and were categorized as ALT-only positive donors. Fourteen ALT-only positive donors who all tested negative in subsequent TTDM and nucleic acid testing (NAT) screening were followed up. The return rate for ALT-only positive donors was reduced by 4.1 times as compared with qualified blood donors (P<0.000). The results suggest that ALT testing does not make a significant contribution to reducing the risk of transfusion-transmitted diseases. Furthermore, being disqualified even once owing to elevated ALT levels has a significant impact on donors' return behavior. Therefore, a suitable cutoff value for ALT testing should be considered based on the evaluated risk in both blood safety and supply.

show abstract

“…Lawlor et al (45) similarly reported in 2005 that PA decreased levels of ALT. Liver function has previously been associated with the distribution of regional fat (46). In results consistent with those of earlier studies, we also found that changes in the lipid‐transport protein apolipoprotein A and high‐density lipoprotein cholesterol from PA (47,48) were partially responsible for reductions in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Walking in the Light: How History of Physical Activity, Sunlight, and Vitamin D Account for Body Fat—A UK Biobank Study

Klinedinst

Meier

Larsen

et al. 2020

Obesity

View full text Add to dashboard Cite

Objective: The high prevalence of vitamin D deficiency and obesity drives the need for successful strategies that elevate vitamin D levels, prevent adipogenesis, and stimulate lipolysis. This study provides a theoretical model to evaluate how physical activity (PA) and sunlight exposure influence serum vitamin D levels and regional adiposity. This study hypothesized a posteriori that sunlight is associated with undifferentiated visceral adiposity by increasing the ratio of brown to white adipose tissue. Methods: Using 10-year longitudinal data, accelerometry, a sun-exposure questionnaire, and regional adiposity quantified by dual-energy x-ray absorptiometry imaging, a structural-equation mediation model of growth curves was constructed with a data-driven methodology. Results: Sunlight and PA conjointly increased serum vitamin D. Changes in vitamin D levels partially mediated how sunlight and PA impacted adiposity in visceral and subcutaneous regions within a subjective PA model. In an objective PA model, vitamin D was a mediator for subcutaneous regions only. Interestingly, sunlight was associated with less adiposity in subcutaneous regions but greater adiposity in visceral regions. Conclusions: Sunlight and PA may increase vitamin D levels. For the first time, this study characterizes a positive association between sunlight and visceral adiposity. Further investigation and experimentation are necessary to clarify the physiological role of sunlight exposure on adipose tissue.

show abstract

Visceral fat is associated with elevation of serum alanine aminotransferase and gamma glutamyltransferase in middle-aged Chinese adults

Cited by 4 publications

References 30 publications

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa

Significance of alanine aminotransferase testing in blood donor screening in Chongqing, China: a 7-year retrospective analysis

Walking in the Light: How History of Physical Activity, Sunlight, and Vitamin D Account for Body Fat—A UK Biobank Study

Contact Info

Product

Resources

About