Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study

Wang, Wei; Zhang, Xueyan; Bai, Xiaoyan; Zhang, Yingkui; Yuan, Ziyu; Tang, Hefei; Li, Zhiye; Hu, Zhangxuan; Zhang, Yaqing; Yu, Xueying; Sui, Binbin; Wang, Yonggang

doi:10.1186/s10194-022-01452-6

Cited by 14 publications

(20 citation statements)

References 63 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to previous PAG 1 H-MRS studies, [12][13][14][15] this study's approach allowed higher regional specificity together with quantification of neurobiologically relevant metabolites detected at short TEs such as Glx. Because these previous studies did not report spectral quality measures, a direct quality comparison is not possible.…”

Section: Discussionmentioning

confidence: 99%

“…In the PAG, 1 H-MRS has been investigated in patients with chronic migraine, 12,13 chronic daily headaches, 14 and chronic whiplash injury. 15 Yet, the number of 1 H-MRS studies in the PAG is limited, which may be due to several difficulties associated with 1 H-MRS acquisition in this region: first, the PAG is a small structure of approximately 4-5 mm diameter and 14 mm length, 16 i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Another option is to sacrifice regional specificity by using volume of interest (VOI) sizes lager than the PAG itself, e.g. 20x20x20 mm 3 , 13,14 because the signal to noise ratio (SNR) increases proportionally to VOI size. 19 Smaller VOIs require longer acquisition times to achieve sufficient SNR, which might in turn impair the spectral quality because of increasing frequency drifts over time and a higher risk for head motion inducing additional frequency and phase errors.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improving magnetic resonance spectroscopy in the brainstem periaqueductal grey using spectral registration

Sirucek

Zoelch

Schweinhardt

2023

Preprint

View full text Add to dashboard Cite

Purpose: Functional understanding of the periaqueductal grey (PAG), a physiologically and clinically highly relevant brainstem region, can be advanced using proton magnetic resonance spectroscopy (1H-MRS). However, the PAG's small size and high levels of physiological noise are methodologically challenging. This study aimed to (1) improve 1H-MRS data quality in the PAG using spectral registration for frequency and phase error correction, (2) investigate whether spectral registration is particularly useful in cases of greater head motion and (3) examine two metabolite quantification approaches using literature-based or individual-based water relaxation times. Methods: Spectra were acquired in 33 healthy volunteers (50.1 years, SD=17.19, 18 females) on a 3T Philipps MR system using a point-resolved spectroscopy sequence optimized with very selective saturation pulses (OVERPRESS) and voxel-based flip angle calibration (effective volume of interest size: 8.8x10.2x12.2 mm3). Results: Spectral registration significantly improved signal-to-noise ratios (SNR; p=0.048, median value [interquartile range]: 18.0 [17.00-20.00]) and spectral linewidth (N-acetylaspartate peak: p<0.001, 4.3 Hz [3.96-4.85]), as well as metabolite fit (p's<0.046) compared to post-processing with minimal frequency alignment using interleaved unsuppressed water peaks. Correlational analyses revealed smaller improvements in SNR in cases of greater head motion (p=0.002) recorded with a markerless motion tracking system. Metabolite concentrations were higher when quantified using individual-based compared to literature-based water relaxation times (p's<0.001). Conclusion: This study demonstrates that high-quality 1H-MRS can be acquired in the PAG using spectral registration. This offers new opportunities for future 1H-MRS studies in the PAG and possibly also other clinically relevant brain regions with similar methodological challenges.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improving magnetic resonance spectroscopy in the brainstem periaqueductal grey using spectral registration

Sirucek

Zoelch

Schweinhardt

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…This substudy is one of multiple planned analyses. The data and all results involved in this study were first analyzed and reported, except data regarding the age, sex, and body mass index of 16 HCs, which were described in the previous reports 21,22 …”

Section: Methodsmentioning

confidence: 99%

“…Severe (20)(21)(22)(23)(24)(25)(26)(27), n (%) 2 (9.1%) Depression (PHQ-9 score ≥ 10), n (%) 10 (45.5%)…”

Section: Questionnaires and Scales Ndph (N = 22)mentioning

confidence: 99%

Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space

et al. 2023

Self Cite

View full text Add to dashboard Cite

Objectives To investigate the glymphatic function in patients with new daily persistent headache (NDPH) using the diffusion tensor image analysis along the perivascular space (DTI‐ALPS) method. Background NDPH, a rare and treatment‐refractory primary headache disorder, is poorly understood. There is limited evidence to suggest that headaches are associated with glymphatic dysfunction. Thus far, no studies have evaluated glymphatic function in patients with NDPH. Methods In this cross‐sectional study conducted in the Headache Center of Beijing Tiantan Hospital, patients with NDPH and healthy controls were enrolled. All participants underwent brain magnetic resonance imaging examinations. Clinical characteristics and neuropsychological evaluation were examined in patients with NDPH. ALPS indexes for both hemispheres were measured to determine the glymphatic system function in patients with NDPH and healthy controls. Results In total, 27 patients with NDPH (14 males, 13 females; age [mean ± standard deviation (SD)]: 36.6 ± 20.6) and 33 healthy controls (15 males, 18 females; age [mean ± SD]: 36.0 ± 10.8) were included in the analysis. No significant differences between groups were observed in the left ALPS index (1.583 ± 0.182 vs. 1.586 ± 0.175, mean difference = 0.003, 95% confidence interval [CI] of difference = −0.089 to 0.096, p = 0.942), or right ALPS index (1.578 ± 0.230 vs. 1.559 ± 0.206, mean difference = −0.027, 95% CI of difference = −0.132 to 0.094, p = 0.738). Additionally, ALPS indexes were not correlated with clinical characteristics or neuropsychiatric scores. Conclusion No glymphatic dysfunction was detected in patients with NDPH by means of the ALPS method. Additional studies with larger samples are needed to confirm these preliminary findings and improve the understanding of glymphatic function in NDPH.

show abstract

Improving magnetic resonance spectroscopy in the brainstem periaqueductal gray using spectral registration

Sirucek,

Zoelch,

Schweinhardt

2023

Magnetic Resonance in Med

View full text Add to dashboard Cite

PurposeFunctional understanding of the periaqueductal gray (PAG), a clinically relevant brainstem region, can be advanced using 1H‐MRS. However, the PAG's small size and high levels of physiological noise are methodologically challenging. This study aimed to (1) improve 1H‐MRS quality in the PAG using spectral registration for frequency and phase error correction; (2) investigate whether spectral registration is particularly useful in cases of greater head motion; and (3) examine metabolite quantification using literature‐based or individual‐based water relaxation times.MethodsSpectra were acquired in 33 healthy volunteers (50.1 years, SD = 17.19, 18 females) on a 3 T Philipps MR system using a point‐resolved spectroscopy (PRESS) sequence optimized with very selective saturation pulses (OVERPRESS) and voxel‐based flip angle calibration (effective volume of interest size: 8.8 × 10.2 × 12.2 mm3). Spectra were fitted using LCModel and SNR, NAA peak linewidths and Cramér‐Rao lower bounds (CRLBs) were measured after spectral registration and after minimal frequency alignment.ResultsSpectral registration improved SNR by 5% (p = 0.026, median value post‐correction: 18.0) and spectral linewidth by 23% (p < 0.001, 4.3 Hz), and reduced the metabolites' CRLBs by 1% to 15% (p < 0.026). Correlational analyses revealed smaller SNR improvements with greater head motion (p = 0.010) recorded using a markerless motion tracking system. Higher metabolite concentrations were detected using individual‐based compared to literature‐based water relaxation times (p < 0.001).ConclusionThis study demonstrates high‐quality 1H‐MRS acquisition in the PAG using spectral registration. This shows promise for future 1H‐MRS studies in the PAG and possibly other clinically relevant brain regions with similar methodological challenges.

show abstract

Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study

Cited by 14 publications

References 63 publications

Improving magnetic resonance spectroscopy in the brainstem periaqueductal grey using spectral registration

Improving magnetic resonance spectroscopy in the brainstem periaqueductal grey using spectral registration

Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space

Improving magnetic resonance spectroscopy in the brainstem periaqueductal gray using spectral registration

Contact Info

Product

Resources

About