Improving magnetic resonance spectroscopy in the brainstem periaqueductal gray using spectral registration
Laura Sirucek,
Niklaus Zoelch,
Petra Schweinhardt
Abstract:PurposeFunctional understanding of the periaqueductal gray (PAG), a clinically relevant brainstem region, can be advanced using 1H‐MRS. However, the PAG's small size and high levels of physiological noise are methodologically challenging. This study aimed to (1) improve 1H‐MRS quality in the PAG using spectral registration for frequency and phase error correction; (2) investigate whether spectral registration is particularly useful in cases of greater head motion; and (3) examine metabolite quantification usin… Show more
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