Galloyl Group is not Necessary for a Sedative Effect of Catechin Through GABAergic System

Adachi, Nami; Tomonaga, Shozo; Suenaga, Rie; Denbow, D. Michael; Furuse, Mitsuhiro

doi:10.2174/157018007780077444

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system [25]. Earlier investigation has also demonstrated that phenolic acids such as epicatechin were found to be ligands for the GABA A receptors in the central nervous system [26], which led to assumption that they can act as benzodiazepine-like molecules.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from the Methanol Extract ofCnicus arvensis(L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice

Rahman

Khatun

Nesa

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Cnicus arvensis is used by many ethnic groups for inflammation, pain, and other ailments. In this study, reducing sugar, carbohydrate, alkaloid, steroid, tannin, flavonoid, and saponin groups were identified using standard chromogenic method. In high-performance liquid chromatography, vanillic acid and epicatechin were identified in the extract. Antinociceptive test by acetic acid induced writhing inhibition resulted 43.17 and 95.08% inhibition for 100 and 200 mg/kg body weight, comparing with standard diclofenac Na with 74.86% inhibition for 25 mg/kg body weight. In formalin induced paw licking test for antinociceptive activity, the extract inhibited 69.87 and 75.55% licking for 150 and 300 mg/kg body weight comparing with the inhibition (68.56%) of diclofenac Na for 10 mg/kg body weight at first phase. At late phase, the extract showed 73.12 and 87.46% licking comparing with licking inhibition (71.69%) by diclofenac Na at the same dose. In open field test for CNS depressant activity, the extract showed depression of locomotor activity for 150 and 300 mg/kg body weight comparing with diazepam for 10 mg/kg body weight. All results were statistically significant (P < 0.01). The identified polyphenols are reputed for antinociceptive and CNS depressant activity. The present findings support the use of this plant in pain.

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Section: Discussionmentioning

confidence: 99%