Tea catechins’ affinity for human cannabinoid receptors

Korte, Gabriele; Dreiseitel, Andrea; Schreier, Peter; Oehme, Anett; Locher, Sanja; Geiger, Sarah S.; Heilmann, Jörg; Sand, Philipp G.

doi:10.1016/j.phymed.2009.10.001

Cited by 32 publications

(16 citation statements)

References 60 publications

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“…Cyanidin and delphinidin, two anthocyanidins found in a wide range of plants, have micromolar affinities for CB 1 [162]. Epigallocatechin-3-O-gallate, the most abundant catechin in tea, also has micromolar affinities for CB 1 [163].…”

Section: Resultsmentioning

confidence: 99%

Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System

2014

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BackgroundThe “classic” endocannabinoid (eCB) system includes the cannabinoid receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and their metabolic enzymes. An emerging literature documents the “eCB deficiency syndrome” as an etiology in migraine, fibromyalgia, irritable bowel syndrome, psychological disorders, and other conditions. We performed a systematic review of clinical interventions that enhance the eCB system—ways to upregulate cannabinoid receptors, increase ligand synthesis, or inhibit ligand degradation.Methodology/Principal FindingsWe searched PubMed for clinical trials, observational studies, and preclinical research. Data synthesis was qualitative. Exclusion criteria limited the results to 184 in vitro studies, 102 in vivo animal studies, and 36 human studies. Evidence indicates that several classes of pharmaceuticals upregulate the eCB system, including analgesics (acetaminophen, non-steroidal anti-inflammatory drugs, opioids, glucocorticoids), antidepressants, antipsychotics, anxiolytics, and anticonvulsants. Clinical interventions characterized as “complementary and alternative medicine” also upregulate the eCB system: massage and manipulation, acupuncture, dietary supplements, and herbal medicines. Lifestyle modification (diet, weight control, exercise, and the use of psychoactive substances—alcohol, tobacco, coffee, cannabis) also modulate the eCB system.Conclusions/SignificanceFew clinical trials have assessed interventions that upregulate the eCB system. Many preclinical studies point to other potential approaches; human trials are needed to explore these promising interventions.

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Section: Resultsmentioning

confidence: 99%

Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System

2014

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“…These include green tea extract-and L-theaninemediated regulation of the secretion of stress hormones that influence cognitive function, including corticosterone [119,120]; EGCG-mediated reduction of amyloid-induced mitochondrial dysfunction [121]; inhibition of glutamate dehydrogenase [122,123], 3,4-dihydroxyphenylalanine decarboxylase [124], and histone acetyltransferase [125]; inhibition of fatty acid synthase by catechins [126,127]; interactions between catechin derivatives and opioid/cannabinoid receptors [128,129]; and L-theanine-mediated modulation of glutamatergic [130], GABAergic [131], dopaminergic [132], and serotoninergic neurotransmission in the brain [132][133][134]. Caffeine is also a psychoactive ingredient of green tea [76] and this stimulates cholinergic neurons by acting as a non-selective antagonist of adenosine A1 and A2A receptors [135].…”

Section: Other Mechanismsmentioning

confidence: 99%

Clinical benefits of green tea consumption for cognitive dysfunction

Ide

Yamada

2015

PharmaNutrition

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“…Fukuda et al reported that the pigments of green tea leaves had the potential to protect against dioxin toxicity through the suppression of aryl hydrocarbon receptor transformation (36). Moreover, EGCG has been suggested to exert binding properties with human cannabinoid receptors and focal adhesion kinase and insulin-like growth factor-I receptors (37,38). Thus, GTE may prevent the down-regulation of muscarinic receptors in CYP-treated bladders by affecting cholinergic neuronal activity.…”

Section: H]nms and [mentioning

confidence: 99%

Beneficial Effects of Gosha-jinki-gan and Green Tea Extract in Rats With Chemical Cystitis

Nasrin¹,

Osano²,

Ito³

et al. 2013

J Pharmacol Sci

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Abstract. The aim of this study was to characterize pharmacological effects of gosha-jinki-gan (GJG) and green tea extract (GTE), on urodynamic parameters, bladder receptors, and urinary cytokines in rats with cyclophosphamide (CYP)-induced cystitis. Urodynamic parameters in CYPtreated rats were measured using the cystometric method. Muscarinic and purinergic receptors in rat tissues were measured by radioreceptor assays. Urinary cytokine levels were measured with ELISA kits. GJG and GTE were orally administered to rats once a day for 7 days. The GJG treatment significantly ameliorated changes in urodynamic parameters in CYP-treated rats. Similar treatment with GTE slightly attenuated changes in urodynamic parameters. The maximal number of binding sites for [ H]NMS and [3 H]ab-MeATP in the bladder was significantly lower in CYPtreated rats than in sham rats. Such a reduction in receptor density was significantly attenuated by the GJG treatment. GTE treatment also significantly attenuated the down-regulation of muscarinic receptors, but not P2X receptors in bladders of rats with CYP-induced cystitis. The elevation in urinary cytokine levels in CYP-treated rats was effectively attenuated by GJG treatment. The elevation in cytokine levels in CYP-treated rats was alleviated by GTE treatment. In conclusion, GJG may be a pharmacologically useful plant extract for cystitis.

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Tea catechins’ affinity for human cannabinoid receptors

Cited by 32 publications

References 60 publications

Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System

Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System

Clinical benefits of green tea consumption for cognitive dysfunction

Beneficial Effects of Gosha-jinki-gan and Green Tea Extract in Rats With Chemical Cystitis

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