Clinical benefits of green tea consumption for cognitive dysfunction

Ide, Kazuki; Yamada, Hiroshi

doi:10.1016/j.phanu.2015.07.001

Cited by 13 publications

(8 citation statements)

References 153 publications

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“…Green tea is a beverage with anti-oxidative stress and neuromodulating properties, as revealed by experimental studies in vitro and in vivo [ 12 – 14 ]; this is also supported by clinical studies [ 15 , 16 ]. Epidemiological studies, including cross-sectional and longitudinal studies, focusing on cognitive function, have yielded contrasting results.…”

Section: Introductionmentioning

confidence: 92%

Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study

Ide

Yamada

Takuma³

et al. 2015

Nutr J

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BackgroundGreen tea is a beverage with potential effects on cognitive dysfunction, as indicated by results of experimental studies. However, its effects in humans, especially at real-world (typical) consumption levels, are unclear.MethodsA double-blind, randomized controlled study was conducted to assess the effects of green tea consumption on cognitive dysfunction (Mini-Mental State Examination Japanese version (MMSE-J) score <28) in Japan. Participants were randomly allocated to the green tea or placebo group, and consumed either 2 g/day of green tea powder (containing 220.2 mg of catechins) or placebo powder (containing 0.0 mg of catechins), respectively, for 12 months. Cognitive function assessments were performed every 3 months using the MMSE-J and laboratory tests.ResultsThirty-three nursing home residents with cognitive dysfunction were enrolled (four men, 29 women; mean age ± SD, 84.8 ± 9.3; mean MMSE-J score ± SD, 15.8 ± 5.4), of whom 27 completed the study. Changes of MMSE-J score after 1 year of green tea consumption were not significantly different compared with that of the placebo group (−0.61 [−2.97, 1.74], least square mean (LSM) difference [95 % CI]; P = 0.59). However, levels of malondialdehyde-modified low-density lipoprotein (U/L), a marker of oxidative stress, was significantly lower in the green tea group (−22.93 [−44.13, −1.73], LSM difference [95 % CI]; P = 0.04).ConclusionsOur results suggest that 12 months green tea consumption may not significantly affect cognitive function assessed by MMSE-J, but prevent an increase of oxidative stress in the elderly population. Additional long-term controlled studies are needed to clarify the effects.Trial registration UMIN000011668 Electronic supplementary materialThe online version of this article (doi:10.1186/s12937-016-0168-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 92%

Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study

Ide

Yamada

Takuma³

et al. 2015

Nutr J

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“…Many studies on the molecular mechanisms of the effects of catechins on AD have been conducted in vivo and in vitro [ 46 , 47 , 48 ], as well as in silico [ 49 ]. Catechins’ known antioxidative effects may contribute to protection from neurodegeneration.…”

Section: Molecular Mechanisms Underlying the Effects Of Catechins mentioning

confidence: 99%

Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

et al. 2018

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Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders worldwide. Its incidence is gradually increasing because of an aging demographic. Therefore, AD prevention and modification is important to improve the health status of older adults. Oxidative stress is a component of the pathological mechanisms underlying AD. It is caused by a disruption of the balance between reactive oxygen species and antioxidant molecules. This imbalance also causes neuroinflammation. Catechins, which are bioactive components of tea, have antioxidative and anti-inflammatory effects. Moreover, other potential properties related to AD prevention and modification have been reported in in vitro and in vivo studies. Several clinical studies have also been conducted to date. The current review summarizes recent updates and perspectives of the effects of catechins on AD based on the molecular mechanisms and related clinical studies.

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“…In red blood cells, caffeine treatment at 100 μ m could fully suppress the activation of protein kinase C, which was induced by the presence of Αβ in AD patients (Carelli‐Alinovi et al ., ). Recently, Ide & Yamada () reviewed experimental studies in vitro and in vivo concerning the effect of tea or tea components on nervous system diseases and indicated that regulation on activity of some important enzymes related to AD might be involved in protection effect of tea or tea components on cognitive dysfunction.…”

Section: Inhibitory Effects Of the Tea Or Tea Components On The Enzymesmentioning

confidence: 99%

Stop for tea? Enzyme inhibitors from tea – what good are they?

Zhao

et al. 2016

Int J of Food Sci Tech

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Summary Tea possesses many bioactive components including polyphenols, theanine and caffeine. Inhibitory effect of these components on the various enzymes involved in some chronic diseases was reviewed in this study. Many studies revealed that anti‐obesity of tea was mainly ascribed to the polyphenols which could inhibit the activity of the enzymes related to diet metabolism such as α‐amylase, α‐glucosidase and lipase. Inhibitory effect of catechins and caffeine against β‐ and γ‐secretase, acetylcholinesterase, protein kinase C and histone deacetylase might be responsible for the prevention from nervous system diseases. Cytochrome P450 enzymes, cytosolic sulfotransferases, cyclooxygenase‐2 and phosphoinositide‐3‐kinase could be efficiently suppressed by catechins, which would decrease the risk of cancer initiation and proliferation; theanine could lower the activity of some anticarcinogen‐activated enzymes and alleviate the adverse effect of cancer cure. Catechins and caffeine exhibited significant inhibition against the matrix metalloproteinases, histidine decarboxylase and many kinases related to inflammation. Thus, catechins, theanine and caffeine might be employed as inhibitors of the enzymes associated with these chronic diseases.

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Clinical benefits of green tea consumption for cognitive dysfunction

Cited by 13 publications

References 153 publications

Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study

Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study

Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

Stop for tea? Enzyme inhibitors from tea – what good are they?

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