Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm

Dong, Junjie; Fang, Dong; Zhang, Lei; Shan, Quan; Huang, Yunchao

doi:10.1016/j.mtla.2019.100209

Cited by 34 publications

(22 citation statements)

References 50 publications

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“…TiNTs have potential applications in several fields; they are found in biomaterials, gas sensors, adsorbents, heterogeneous catalysis ( photocatalysis, oxidation reactions, organic synthesis, biomass,…), biological activities to remove bacteria from water, solar cells, Li battery production, and many others. In particular, TiNTs have been used as a catalytic support for different active species (metals, oxides and sulfides).…”

Section: Introductionmentioning

confidence: 99%

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

Ameur

Bachir

2020

ChemistrySelect

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This paper represents a general study of titanate nanotubes (TiNTs) which are among the most important materials in the field of catalysis. This research work covers more than 100 publications about the formulation, characterisation and most recent applications of TiNTs. TiNTs can be prepared by different methods, namely the anodic deposition, sol-gel template synthesis and alkaline hydrothermal treatment. The present study focuses on the preparation of this tubular structure by alkaline treatment, using the latest and most recent processes that have been introduced in this method (stirring, acid nature, annealing temperature, etc). The surface properties, such as the point of zero charge (P.Z.C), acid-base nature and light absorption, of TiNTs are also evoked. In the end, some recent and important TiNTs applications in the field of renewable energies are reported (H 2 production and methanation). In addition, NO reduction, CO oxidation, photocatalysis and organic synthesis are also mentioned. Therefore, it may be said that this paper is a structured study about TiNTs for the purpose of making the reader aware of their importance, understand their synthesis, and know their scope of applications. To conclude, the most important data, acquired through various characterization techniques, are provided.[a] Dr.

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Section: Introductionmentioning

confidence: 99%

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

Ameur

Bachir

2020

ChemistrySelect

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“…[27] In addition, Ga 3 + is currently approved by the Food and Drug Administration (FDA) as an anti-tumor and antihypercalcemia drug. [28] As indicated in Figure 6a, no significant difference in cell viability was observed at day 1 between 3D-Ti and TNTs-3D-Ti. However, on days 4 and 7, the cell viability on TNTs-3D-Ti was significantly (p < 0.0001) reduced compared to the 3D-Ti.…”

Section: The Influence Of Micro/nano Surface Topography On Mg-63 Viability Proliferation and Morphologymentioning

confidence: 70%

Tailoring Additively Manufactured Titanium Implants for Short‐Time Pediatric Implantations with Enhanced Bactericidal Activity

et al. 2021

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Paediatric titanium (Ti) implants are used for the short-term fixation of fractures, after which they are removed. However, bone overgrowth on the implant surface can complicate their removal. The current Ti implants research focuses on improving their osseointegration and antibacterial properties for longterm use while overlooking the requirements of temporary implants. This paper presents the engineering of additively manufactured Ti implants with antibacterial properties and prevention of bone cell overgrowth. 3D-printed implants were fabricated followed by electrochemical anodization to generate vertically aligned titania nanotubes (TNTs) on the surface with specific diameters (~100 nm) to reduce cell attachment and proliferation. To achieve enhanced antibacterial performance, TNTs were coated with gallium nitrate as antibacterial agent. The physicochemical characteristics of these implants assessed by the attachment, growth and viability of osteoblastic MG-63 cells showed significantly reduced cell attachment and proliferation, confirming the ability of TNTs surface to avoid cell overgrowth. Gallium coated TNTs showed strong antibacterial activity against S. aureus and P. aeruginosa with reduced bacterial attachment and high rates of bacterial death. Thus a new approach for the engineering of temporary Ti implants with enhanced bactericidal properties with reduced bone cell attachment is demonstrated as a new strategy toward a new generation of short-term implants in paediatrics.

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“…As a result, bare/drug-loaded TNTs have been modified with chitosan [79], polydopamine [80], silk fibroin [81] and PLGA (poly(lactic-co-glycolic acid)), which exhibited synergistic bioactivity and antibacterial enhancements. In addition, various antibacterial ions and nanoparticles (NPs), such as Ag [82], Au [83], Cu [84,85], B, P, Ca [86], Ga [87], Mg [88], ZnO [89], etc., have also been immobilized on or incorporated inside TNTs, with or without the use of hydroxyapatite or biopolymers, using techniques such as micro-arc oxidation, chemical reduction, photo-irradiation, spin-coating, and sputtering.…”

Section: Antibacterial Functionsmentioning

confidence: 99%

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Zhang

Gulati

et al. 2021

Nanomaterials

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Titanium (Ti) and its alloys offer favorable biocompatibility, mechanical properties and corrosion resistance, which makes them an ideal material choice for dental implants. However, the long-term success of Ti-based dental implants may be challenged due to implant-related infections and inadequate osseointegration. With the development of nanotechnology, nanoscale modifications and the application of nanomaterials have become key areas of focus for research on dental implants. Surface modifications and the use of various coatings, as well as the development of the controlled release of antibiotics or proteins, have improved the osseointegration and soft-tissue integration of dental implants, as well as their antibacterial and immunomodulatory functions. This review introduces recent nano-engineering technologies and materials used in topographical modifications and surface coatings of Ti-based dental implants. These advances are discussed and detailed, including an evaluation of the evidence of their biocompatibility, toxicity, antimicrobial activities and in-vivo performances. The comparison between these attempts at nano-engineering reveals that there are still research gaps that must be addressed towards their clinical translation. For instance, customized three-dimensional printing technology and stimuli-responsive, multi-functional and time-programmable implant surfaces holds great promise to advance this field. Furthermore, long-term in vivo studies under physiological conditions are required to ensure the clinical application of nanomaterial-modified dental implants.

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Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm

Cited by 34 publications

References 50 publications

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

Tailoring Additively Manufactured Titanium Implants for Short‐Time Pediatric Implantations with Enhanced Bactericidal Activity

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

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