Gallic Acid‐Loaded Electrospun Poly(<scp>L</scp>‐Lactic Acid) Fiber Mats and their Release Characteristic

Chuysinuan, Piyachat; Chimnoi, Nitirat; Techasakul, Supanna; Supaphol, Pitt

doi:10.1002/macp.200800614

Cited by 51 publications

(48 citation statements)

References 32 publications

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“…The evaporation of solvent from the jet solution produces smaller fibers as lower is the polymer content, as reported previously [30, 39, 40]. Chitosan is a cationic polyelectrolyte, and then ion concentration increases with the chitosan content increasing conductivity and also the charge density on the surface of the drop formed in the needle, which increases elongational forces on the jet, hence thinner fiber are expected [9, 41, 42]. However, as the solution concentration increases also does the viscosity that produce thicker fibers [43, 44].…”

Section: Resultssupporting

confidence: 52%

Assessment of parameters influencing fiber characteristics of chitosan nanofiber membrane to optimize fiber mat production

Areias

Gómez-Tejedor

Sencadas

et al. 2012

Polymer Engineering & Sci

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Electrospun chitosan nanofiber mats have been obtained using chitosan solutions in a mixture of trifluoroacetic acid and dichloromethane. The relationship between processing parameters (solvent composition, polymer concentration in the solution, feeding rate, applied voltage, travelling distance between the needle and the collector) and fiber morphology was studied. Taguchi's methodology was followed to determine which parameters have the strongest influence on mean fiber diameter and fiber homogeneity. Chitosan nanofibers obtained with this procedure were water soluble due to the protonation of amine side groups but were successfully neutralized by immersion in calcium carbonate solutions. It was established that fiber diameter is mainly determined by the solution concentration and the distance from the needle to the collector while other parameters have less influence. The set of parameters that produce the thinnest fibers were a concentration of 8 wt%, a TFA/DCM ratio of 80:20 (v/v %), a voltage of 30 kV, a flow rate of 6.0 mL/h, a gap distance of 10 cm, using a needle diameter of 0.5, allowing to produce randomly oriented mats with a mean fiber thickness of 66 nm.

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Section: Resultssupporting

confidence: 52%

Assessment of parameters influencing fiber characteristics of chitosan nanofiber membrane to optimize fiber mat production

Areias

Gómez-Tejedor

Sencadas

et al. 2012

Polymer Engineering & Sci

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“…In addition to that, flexibility of this process enables to obtain nanofibers containing active agents which have potential to be used in diverse application areas [13][14]. Therefore, gallic acid encapsulated polymeric films and electrospun nanofibers have been studied previously [3,5,[15][16]. CD-ICs can be incorporated into polymeric films and then CD-IC functionalized polymeric films might be used in food packaging and pharmaceutical applications [17].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of gallic acid/cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: Release behavior and antioxidant activity of gallic acid

Aytaç

Küskü

Durgun

et al. 2016

Materials Science and Engineering: C

145

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Cyclodextrin-inclusion complexes (CD-ICs) possess great prominence in food and pharmaceutical industries due to their enhanced ability for stabilization of active compounds during processing, storage and usage. Here, CD-IC of gallic acid (GA) with hydroxypropyl-beta-cyclodextrin (GA/HPβCD-IC) was prepared and then incorporated into polylactic acid (PLA) nanofibers (PLA/GA/HPβCD-IC-NF) using electrospinning technique to observe the effect of CD-ICs in the release behavior of GA into three different mediums (water, 10% ethanol and 95% ethanol). The GA incorporated PLA nanofibers (PLA/GA-NFs) were served as control. Phase solubility studies showed an enhanced solubility of GA with increasing amount of HPβCD. The detailed characterization techniques (XRD, TGA and 1 H-NMR) confirmed the formation of inclusion complex between GA and HPβCD. Computational modeling studies indicated that the GA made an efficient complex with HPβCD at 1:1 either in vacuum or aqueous system. SEM images revealed the bead-free and uniform morphology of PLA/GA/HPβCD-IC-NF. The release studies of GA from PLA/GA/HPβCD-IC-NF and PLA/GA-NF were carried out in water, 10% ethanol and 95% ethanol, and the findings revealed that PLA/GA/HPβCD-IC-NF has released much more amount of GA in water and 10% ethanol system when compared to PLA/GA-NF. In addition, GA was released slowly from PLA/GA/HPβCD-IC-NF into 95% ethanol when compared to PLA/GA-NF. It was also observed that electrospinning process had no negative effect on the antioxidant activity of GA when GA was incorporated in PLA nanofibers.

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“…Gallic acid, besides its antimicrobial activity, has been described as a strong anti‐inflammatory agent . A direct relation between the concentration of gallic acid and the inhibition of NO production in LPS/IFN‐γ‐activated macrophages was, also, demonstrated by Wang and coworkers .…”

Section: Resultsmentioning

confidence: 77%

Cotton‐hydrogel composite for improved wound healing: Antimicrobial activity and anti‐inflammatory evaluation—Part 2

Pinho

Calhelha

Ferreira

et al. 2018

Polymers for Advanced Techs

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Infection is one of the major risk factors for the development of chronic wounds. Antimicrobial wound dressing has been pointed out as a viable option for the prevention and treatment of wound infections. Thus, we developed a composite material based on cotton textile substrates functionalized with cyclodextrin‐hydroxypropyl methyl cellulose‐based hydrogel. The composites' ability to encapsulate and release gallic acid (antimicrobial phenolic acid) was evaluated, as well as their mechanical properties and antimicrobial and anti‐inflammatory capacity. All composites were able to retain gallic acid in their structure, with similar loading profile. The presence of gallic acid on composites was confirmed by FTIR and TGA. Composites storage moduli was reduced by the presence of gallic acid. The results suggest a straight relation between the swelling ability and gallic acid drug delivery profile. The drug delivery mechanism, of the developed composites, was mainly controlled by Fickian diffusion, based on the experimental data fitting to the Peppas‐Sahlin model. Gallic acid antimicrobial and anti‐inflammatory properties were transferred to the composite materials. According to the results, the developed composites can be applied on the prevention or treatment of chronic wounds.

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Gallic Acid‐Loaded Electrospun Poly(L‐Lactic Acid) Fiber Mats and their Release Characteristic

Cited by 51 publications

References 32 publications

Assessment of parameters influencing fiber characteristics of chitosan nanofiber membrane to optimize fiber mat production

Assessment of parameters influencing fiber characteristics of chitosan nanofiber membrane to optimize fiber mat production

Encapsulation of gallic acid/cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: Release behavior and antioxidant activity of gallic acid

Cotton‐hydrogel composite for improved wound healing: Antimicrobial activity and anti‐inflammatory evaluation—Part 2

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