Gallic acid induces apoptosis in human cervical epithelial cells containing human papillomavirus type 16 episomes

Shi, Lin; Lei, Yan-Jun; Srivastava, Ranjana; Qin, Weihua; Chen, Jason J.

doi:10.1002/jmv.24291

Cited by 14 publications

(8 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, GA ameliorated the BPA-induced decrease in the activities of antioxidant enzymes together with the elevated levels of ROS. This is in confirmation of the antioxidant properties of GA reported earlier (Rather et al 2013;Shi et al 2016). Our findings show the ability of GA as a potent antioxidant capable of ameliorating BPA-induced oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

“…The polyhydroxyphenolic compound, gallic acid, GA (3,4,5-trihydroxybenzoic acid), has been detected in vegetables and fruits including banana, pineapple, gallnut, grapes, apple, sumac, oak bark, lemons, and as a content of a number of beverages derived from plants including teas and fruit juices (Galati and O'Brien 2004;Madlener et al 2007). Studies have demonstrated the antiallergic, antimutagenic, anti-inflammatory, and anticarcinogenic activities of gallic acid via its antioxidant property (Rather et al 2013;Shi et al 2016). Gallic acid extracted from the rose flowers had been demonstrated to possess certain anti-oxidative properties (Li et al 2005).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid

Olukole

Ola-Davies

Lanipekun

et al. 2020

Endocrine Regulations

View full text Add to dashboard Cite

Objectives. Bisphenol A (BPA) has been reported that among other male reproductive dys-functions, it can cause marked estrogenic effects including alteration in serum hormones as well as testicular lesions in exposed animals. This work sought to study the role of gallic acid (GA), a known antioxidant, on the BPA-induced testicular oxidative stress in adult male Wistar rats using serum hormone analysis, histopathology, and biochemical assays.Methods. Adult male rats were divided into four groups (n=10) including control (0.2 ml of corn oil), GA (20 mg/kg/day), BPA (10 mg/kg/day), BPA+GA (BPA, 10 mg/kg/day + GA, 20 mg/kg/day). All medications were given by oral gavage for 45 consecutive days. The body and testicular weights were measured. Blood and organ samples were collected for the serum hormonal assay: testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL), and tissue biochemistry analysis: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione-S-transferase (GST), malondialdehyde (MDA), hydrogen peroxide (H2O2), respectively.Results. The BPA-treated rats showed significant reduction in the gonadosomatic index. BPA also caused significant decrease in the levels of the serum testosterone and prolactin. Furthermore, BPA induced testicular oxidative stress by decreasing the activities of antioxidant enzymes and increasing reactive oxygen species. However, co-treatment with GA protected against these alterations.Conclusion. Findings from the present study confirmed the previously reported data and show that the ability of GA, as a potent antioxidant, may protect against BPA-induced alterations in the male reproductive function. Hence, GA protects against testicular oxidative stress in adult male Wistar rats following chronic exposure to BPA.

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid

Olukole

Ola-Davies

Lanipekun

et al. 2020

Endocrine Regulations

View full text Add to dashboard Cite

show abstract

“…Gallic acid is widely recognized as having antioxidant and anti-tumor activities [34]. In this study, the gallic acid content gradually increased from a range of 5.02 to 5.84 ug/g DW during the germination process.…”

Section: Phenolic Acidsmentioning

confidence: 73%

The Effects of Germination on the Phenolic Acids and Antioxidant Activity of Purple Perilla (Perilla Frutescens Var. Acuta) Sprouts

Liu¹,

Jing-ruo²,

Liu³

et al. 2018

Medical and Pharmaceutical Research (WCMPR 2017)

View full text Add to dashboard Cite

In this study, the influence of germination on the phenolic profile and antioxidant activities of purple perilla sprouts was investigated. The results demonstrated that the total phenolic content, total flavonoid content, and antioxidant activities of purple perilla sprouts significantly increased (p< 0.05) when compared to those of purple perilla seeds. The maximum amount of the total phenolic content was found to be 23.78 mg GAE/ g DW at the first stage (G1), which was an increase of 142.98% when compared with those of the seeds. The total flavonoid content reached the maximum value of 95.38 mg RE/ g DW, which was up 316.50% when compared with those of the seeds at the G2 stage. Among the six phenolic compounds which were identified and quantified, five significantly increased during germination. These findings suggested that germination can be used as a new approach for the further development of purple perilla sprouts as a potential food for human consumption. INTRODUCTIONPurple perilla (Perilla frutescens var. acuta) is an annual eatable herbaceous plant native to Asia, which belongs to the Lamiaceae family [1,2]. It has been consumed as an edible vegetable, and can be used in food ingredients, oil crops, or medicinal materials [3,4]. Perilla seeds contain approximately 51% total lipids, and its essential oils are used in perfumes, soaps, detergents, and cosmetics [5,6]. Purple perilla leaves are used in salads, sushi, and soups, as well as pickles and garnishes [3]. Several studies have suggested that Perilla frutescens leaves and oils display a range of biological activities, including antiallergic, antiinflammatory, antitumour, antioxidant, and antiimmune characteristics, which have been attributed to phenolic compounds such as caffeic acid, rosmarinic acid , rosmarinic acid methyl ester, and triterpene acids [7][8][9][10][11][12][13][14]. Phenolic acids seem to have the greatest healthpromoting potential as a result of their scavenging free radicals, inhibition of lipid peroxidation, and thus their anticancer activity [15].Germination is an inexpensive and effective method for increasing the nutritive and health qualities of plants [16]. Many studies have been conducted regarding the changes in phenolic compounds, as well as the antioxidant activities, of germinated seeds. There some researchers reported that the content of phenolic profiles and antioxidant activities increased significantly during the germination of buckwheat [17]. Other researchers reported that thirteen germinated edible seeds (mung bean, alfalfa, fava, fenugreek, mustard, wheat, broccoli, sunflower, soybean, radish, kale, lentil, and onion) were excellent sources of dietary phenolic antioxidants [18]. Some group researchers also have reported that germination increased the total phenolic and flavonoid levels, as well as the AA of the seeds, and also influenced the profile of the free and bound phenolic compounds during the germination of mung beans, radish, broccoli, and sunflowers [19]. However, almost no information exists...

show abstract

“…It also down-regulated the expression of anti-apoptosis proteins such as Bcl-2 and x-linked inhibitor of apoptosis protein (Xiap). In contrast, delayed expression of pro-apoptosis related proteins was observable in non-cancerous cells and no reduction of survival-related protein expression was found in the non-cancerous cells [53].…”

Section: Effect Of P Macrocarpa On Cervical Cancermentioning

confidence: 74%

A Role for Phaleria Macrocarpa (Scheff) Boerl. Extracts in the Management of Women’s Pathological Conditions: A Research Review

Tjandrawinata¹,

Rouli²

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

ABSTRACT`Phaleria macrocarpa (Scheff) Boerl is a medicinal plant that originates from West Papua, Indonesia. The fruit of this plant is known to contain numerous different compounds that produce different bioactivities. Many of these bioactivities are related to women pathological conditions. The purpose of this review is to evaluate the effect of P. macrocarpa fruit extract in the management of these conditions. Different studies have proven that P. macrocarpa extract helps regulate hormone imbalance in women with problems relating to their menstruation cycle, especially during premenstrual syndrome. It helps alleviate symptoms of primary dysmenorrhea and endometriosis through its bioactivity as anti-inflammation, apoptosis inducer, anti-angiogenic and anti-oxidant agent. P. macrocarpa fruit extract also showed selective anti-proliferative, anti-inflammatory, and anti-angiogenic activity on breast and cervical cancer cells. It regulates cancer cell progression through numerous different pathways, making it highly favourable to be developed as a cancer treatment, whether as a single treatment or as an adjunct therapy. In conclusion, P. macrocarpa extract has great potential to be developed into treatments for women's pathological conditions. However, further study, both preclinical and clinical studies are needed to ascertain its use in women to be effective and safe.

show abstract

Gallic acid induces apoptosis in human cervical epithelial cells containing human papillomavirus type 16 episomes

Cited by 14 publications

References 49 publications

Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid

Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid

The Effects of Germination on the Phenolic Acids and Antioxidant Activity of Purple Perilla (Perilla Frutescens Var. Acuta) Sprouts

A Role for Phaleria Macrocarpa (Scheff) Boerl. Extracts in the Management of Women’s Pathological Conditions: A Research Review

Contact Info

Product

Resources

About