2019
DOI: 10.1016/j.archoralbio.2019.03.002
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Galleria mellonella as an experimental model to study human oral pathogens

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Cited by 27 publications
(17 citation statements)
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“…The use of the invertebrate Galleria mellonella has become an alternative experimental in vivo infection model to traditional mammals. The larvae are easy to maintain and manipulate, and have similarities with the mammalian innate immune system, including the cellular immune response performed by hemocytes present in the insect's hemolymph …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The use of the invertebrate Galleria mellonella has become an alternative experimental in vivo infection model to traditional mammals. The larvae are easy to maintain and manipulate, and have similarities with the mammalian innate immune system, including the cellular immune response performed by hemocytes present in the insect's hemolymph …”
Section: Introductionmentioning
confidence: 99%
“…The larvae are easy to maintain and manipulate, and have similarities with the mammalian innate immune system, including the cellular immune response performed by hemocytes present in the insect's hemolymph. 23,24 Treating oral diseases with a natural and non-invasive method has great appeal and can prevent problems related to pharmacological treatments, such as antibiotic resistance. Considering that conventional periodontal treatment fails to control periodontal disease progression in some patients and that L reuteri has been successfully used as an adjunct alternative in some clinical studies, we have hypothesized that heat-killed L reuteri (paraprobiotic) and L reuteri cell-free supernatant may be effective in cases of P gingivalis infection.…”
Section: Introductionmentioning
confidence: 99%
“…mutans extracts using two different in vivo models. The G. mellonella model is a prompt and reliable method to evaluate toxicity and efficacy of antifungal agents ( Junqueira and Mylonakis, 2019 ; Lin et al, 2019 ; Rossoni et al, 2019 ). The S. mutans extract tested concentrations were not toxic to the host.…”
Section: Discussionmentioning
confidence: 99%
“…Waxworms are captive-bred worldwide as food for amphibians, reptiles, and fish, and are easy to purchase and maintain (Table 1). For injection of waxworms, the worms are anesthetized on ice and injected using a syringe with a 30-gauge needle, 18,19 or held in a special apparatus and injected. 20 Because waxworms can grow at 37°C, 21 infection experiments can be performed at 37°C.…”
Section: Waxworm (Galleria Mellonella)mentioning
confidence: 99%