2020
DOI: 10.1111/1348-0421.12834
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Animal infection models using non‐mammals

Abstract: The use of non‐human animal models for infection experiments is important for investigating the infectious processes of human pathogenic bacteria at the molecular level. Mammals, such as mice and rabbits, are also utilized as animal infection models, but large numbers of animals are needed for these experiments, which is costly, and fraught with ethical issues. Various non‐mammalian animal infection models have been used to investigate the molecular mechanisms of various human pathogenic bacteria, including St… Show more

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Cited by 49 publications
(44 citation statements)
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“…The results support that the silkworm infection model is useful for the evaluation of antibacterial drugs against systemic infection by C. acnes . Silkworm infection models are useful for identifying virulence factors of pathogenic microorganisms [ 13 , 15 ]. Further studies are needed to determine which factors in C. acnes are responsible for the pathogenicity against silkworms.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The results support that the silkworm infection model is useful for the evaluation of antibacterial drugs against systemic infection by C. acnes . Silkworm infection models are useful for identifying virulence factors of pathogenic microorganisms [ 13 , 15 ]. Further studies are needed to determine which factors in C. acnes are responsible for the pathogenicity against silkworms.…”
Section: Discussionmentioning
confidence: 99%
“…Silkworms are useful animals for assessing host–pathogen interactions in systemic infections and for evaluating the therapeutic effects of antimicrobial drugs [ 12 , 13 , 14 ]. Because silkworms also have advantageous features, such as easy rearing in large numbers in a small space with few ethical issues, experiments with large numbers of silkworms can be performed [ 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…This could be due to several reasons. Firstly, there is the financial aspect; compared to invertebrates, zebrafish come along with higher costs for housing and husbandry, yet these costs are still much lower than with higher animals [ 18 ]. In addition, some injection techniques required for the infection of zebrafish are quite laborious and, depending on the purpose of the study, it might be more convenient to choose a less complex model organism.…”
Section: Non-mammalian Models In Pharmaceutical Researchmentioning
confidence: 99%
“…Novel virulence genes in the pathogenic bacterium Staphylococcus aureus were identi ed using a silkworm infection model and a library of gene-de cient strains 20,21 . Silkworm infection models have also been used to identify virulence genes of the pathogenic fungi C. albicans and Candida glabrata [22][23][24] .…”
Section: Introductionmentioning
confidence: 99%