2019
DOI: 10.1111/jre.12704
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Heat‐killed Lactobacillus reuteri and cell‐free culture supernatant have similar effects to viable probiotics during interaction with Porphyromonas gingivalis

Abstract: Background and objective In the last decade, numerous studies have been published to clarify the role of probiotics, especially Lactobacillus reuteri, as an adjunct to conventional periodontal treatment. Although the health benefits of probiotics are numerous, they are live bacteria, and the administration of live organisms is not risk‐free. We evaluated the antimicrobial effect of L reuteri and its cell‐free culture supernatant on Porphyromonas gingivalis, a keystone periodontal pathogen, in vitro. We also ev… Show more

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Cited by 38 publications
(29 citation statements)
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“…After cultivation in the reuterincontaining supernatant of L. reuteri, S. mutans survival was reduced nearly completely. Our results are in line with those from clinical studies finding L. reuteri to be an efficacious probiotic to combat oral pathogens (Lin et al, 2017;Geraldo et al, 2019).…”
Section: Discussionsupporting
confidence: 91%
“…After cultivation in the reuterincontaining supernatant of L. reuteri, S. mutans survival was reduced nearly completely. Our results are in line with those from clinical studies finding L. reuteri to be an efficacious probiotic to combat oral pathogens (Lin et al, 2017;Geraldo et al, 2019).…”
Section: Discussionsupporting
confidence: 91%
“…Modulation of the G. mellonella immune response has been reported by different studies using probiotics (Ribeiro et al, 2017;Rossoni et al, 2017;Scalfaro et al, 2017;Geraldo et al, 2019). The main cells involved in the cellular immune response of G. mellonella are hemocytes (Bergin et al, 2003;Sheehan and Kavanagh, 2018).…”
Section: Discussionmentioning
confidence: 98%
“…A recent systematic review 104 has summarized the clinical effect of probiotic when it was performed to nonsurgical periodontal treatment as adjunctive therapy and demonstrated that adjunctive use of Lactobacillus reuteri showed significant impacts on the improvement of periodontal parameters and reduction of gingival inflammation. Furthermore, probiotic (i.e., Akkermansia muciniphila ) treatment has demonstrated an inhibitory effect towards Porphyromonas gingivalis ‐induced periodontal destruction and inflammation 105,106 . Considering these facts, manipulation of the oral microbiota in an adult may effectively prevent the onset of periodontal and systemic disease.…”
Section: Prevention and Treatmentmentioning
confidence: 99%