Gallbladder metastasis from renal cell carcinoma mimicking acute cholecystitis

Sand, Michael; Bechara, F. G.; Kopp, Juergen; Krins, N.; Behringer, Dirk; Mann, B.

doi:10.1186/2047-783x-14-2-90

Cited by 23 publications

(14 citation statements)

References 12 publications

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“…In fact, this is the first report of metastasize inside the gallbladder from a tumor of colon origin. There are few reports describing gallbladder metastasize from other origins [ 13 – 16 ]. The prognostic of these patients was very poor with most of them achieving <1-year survival.…”

Section: Commentsmentioning

confidence: 99%

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma

Galvão

Pestana

Capelozzi

2009

Cancer Chemother Pharmacol

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Gemcitabine is a chemotherapy agent that may cause unpredictable side eVects. In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed. CT scan and ultrasound before the surgery did not show any tumor. After the surgery a Pet scan was positive for a hot-spot in the left colon. The colonic lesion was conveniently removed and the histology evaluation conWrmed the diagnosis of adenocarcinoma tubular. The patient was then submitted to three sections of 1,600 mg/m 2 of gemcitabine with intervals of 1 week. Three weeks later he developed severe respiratory distress. A helicoidal CT scan showed diVuse and severe interstitial pneumonitis, and lung biopsy conWrmed accelerated usual interstitial pneumonia consistent with drug-induced toxicity. The patient presented unfavorable evolution with progressive worsening of respiratory function, hypotension, and renal failure. He died 1 month later in spite of methylprednisolone pulse therapy, large spectrum antimicrobial therapy, and full support of respiratory, hemodynamic and renal systems. Gemcitabine-induced pulmonary toxicity is usually a dramatic condition. Physicians should suspect pulmonary toxicity in patients with respiratory distress after gemcitabine chemotherapy, mainly in elderly patients.

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Section: Commentsmentioning

confidence: 99%

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma

Galvão

Pestana

Capelozzi

2009

Cancer Chemother Pharmacol

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“…Metastatic disease is common, and one third of newly diagnosed cases will have synchronous metastatic disease at presentation. A further 25–50 % will develop metachronous disease [2]. Latent distant metastasis is characteristic of renal cell carcinoma (RCC) and can manifest more than a decade after nephrectomy in about 10 % of patients [3].…”

Section: Introductionmentioning

confidence: 99%

Two cases of gallbladder metastasis from renal cell carcinoma and review of literature

et al. 2016

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BackgroundRenal cell carcinoma accounts for 90 % of renal neoplasms and metastatic disease is common. One third of newly diagnosed cases will have synchronous metastases at diagnosis and further 25–50 % will develop metachronous disease. Case PresentationThis study presents two new cases of gallbladder metastasis from renal cell carcinoma (RCC) from our institution and reviews the published literature. The final cohort included 52 evaluable patients. M/F ratio was 2:1 and median age was 62.5 years. Most patients were diagnosed incidentally after follow-up or staging imaging for RCC. Of the patients with available histology, all except one were clear cell type (n = 39) and 92 % were polypoid. Thirty-six patients demonstrated metachronous gallbladder metastasis with median disease-free interval (DFI) from nephrectomy of 4 years. The most frequent site of metastasis was the contralateral kidney (46.7 %) followed by the pancreas and lung. The median disease-free interval (DFS) after cholecystectomy was 37 months. Three- and five-year OS rates were 74 and 62 %, respectively. Age younger than 45 years (p = 0.008) and DFI <24 months (p = 0.049) were associated with decreased OS.ConclusionsRCC metastasis to the gallbladder is associated with an unusual pattern of concomitant metastasis. Symptoms are not common. Simple cholecystectomy is associated with increased OS and nil local or port site recurrence. Young age and short DFI are associated with decreased OS.Electronic supplementary materialThe online version of this article (doi:10.1186/s12957-016-0843-3) contains supplementary material, which is available to authorized users.

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“…The most common presenting condition appears to be cholecystitis, although cholelithiasis, jaundice, and biliary dyskinesia have also been reported as presentations. Breast carcinoma metastasis to the gallbladder is often diagnosed on histopathological examination following cholecystectomy [13–23] . After performing a search of the PubMed database, a review of 12 articles on breast carcinoma metastasis to the gallbladder revealed that the time between breast cancer diagnosis and presentation of gallbladder metastasis ranges from 1 month to 10 years [13–24] .…”

Section: Discussionmentioning

confidence: 99%

Concomitant endometrial and gallbladder metastasis in advanced multiple metastatic invasive lobular carcinoma of the breast: A rare case report

Bezpalko¹,

Mohamed²,

Mercer³

et al. 2015

International Journal of Surgery Case Reports

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HighlightsBreast cancer metastasis to the uterus or gallbladder is rare.Metastatic breast carcinoma should be ruled out in females presenting with thrombocytopenia.Invasive lobular carcinoma has a unique pattern of metastasis compared to most other types of breast cancer.High index of suspicion should be maintained in patients with invasive lobular breast carcinoma for unusual patterns of metastasis.Invasive lobular breast carcinoma may metastasize synchronously to the endometrium and gallbladder.Metastatic spread should be considered in the differential diagnosis of patients with invasive lobular breast carcinoma presenting with abnormal vaginal bleeding or acute cholecystitis.

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Gallbladder metastasis from renal cell carcinoma mimicking acute cholecystitis

Cited by 23 publications

References 12 publications

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma

Two cases of gallbladder metastasis from renal cell carcinoma and review of literature

Concomitant endometrial and gallbladder metastasis in advanced multiple metastatic invasive lobular carcinoma of the breast: A rare case report

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