Galectin-3 and neutrophil-to-lymphocyte ratio are indicative of heart remodelling and disease severity in patients with obstructive sleep apnoea

Cicco, Sebastiano; Castellana, Giorgio; Marra, Lorenzo; Lecce, Vincenzo Di; Carratù, Pierluigi; Prete, Marcella; Ranieri, G.; Resta, Onofrio; Carpagnano, Giovanna Elisiana; Racanelli, Vito; Dragonieri, Silvano; Vacca, Angelo

doi:10.1016/j.sleep.2021.03.039

Cited by 11 publications

(6 citation statements)

References 47 publications

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“…The negative correlation of gal-3 concentration with the parameters assessing the size of the LA, which would indicate the possibility of a reduction of dimensions and volume of the left atrial cavity due to fibrosis, partly contradicts current reports. Some authors state that the correlations between the size of the LA and the concentration of gal-3 in their study groups were significantly positive, and some say that no such correlation was found [43][44][45]. The relationship between gal-3 concentration and fibrosis of the left atrial or right appendage is also inconsistent in the available literature [30,44,45].…”

Section: Discussionmentioning

confidence: 97%

Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation

et al. 2021

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Galectin-3 (gal-3) is a fibrosis marker and may play a role in fibrosis of the left atrium (LA). Left atrial wall fibrosis may influence the transition from paroxysmal to non-paroxysmal atrial fibrillation (AF). In this study, we assessed the correlation of gal-3 concentration with the main echocardio-graphic parameters evaluating dimensions, volume, compliance, and left atrial contractility during AF and after successful electrical cardioversion (DCCV). The study included 63 patients with left atrial enlargement who qualified for DCCV due to persistent AF. The procedure recovered sinus rhythm in 43 (68.3%) patients. The concentration of gal-3 was negatively correlated with the echocardiographic parameters of LA including dimensions (LA length pre, rho = −0.38; p = 0.003), volume (LAV pre, rho = −0.39; p = 0.003), compliance (LASr mean post, rho = −0.33) and contractility (pLASRct mean post, rho = −0.33; p = 0.038). Negative correlations of gal-3 concentration were also observed in relation to the volume and contractility of the left ventricle. The concentration of gal-3 significantly negatively correlates with the size, systolic function, and compliance of the LA wall in patients with persistent AF. Determining gal-3 concentration in patients with persistent AF may help in the assessment of remodeling of the LA wall.

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Section: Discussionmentioning

confidence: 97%

Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation

et al. 2021

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“…On the basis of the conducted analyzes, it was shown that all 3 groups (C, G1, G2) did not The demonstration of high values of the LVMI in the group of normotensive patients suggests that in patients with OSA, the causes of LVH may be other than arterial hypertension. It has been proven that in patients with OSA there is an increase in the level of inflammatory factors, for example, Galectine-3, that may be responsible for LVH [11]. Thus, it is possible that OSA may have an influence on the left ventricular mass, regardless of the coexisting hypertension.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of target organ damage in hypertensive patients with coexisting obstructive sleep apnea

Myśliński¹,

Szwed²,

Szwed³

et al. 2022

Ann Agric Environ Med.

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Introduction and Objective.Obstructive sleep apnea (OSA) is associated with cardiovascular risk and higher mortality. Assessment of subclinical organ lesions is significant for prevention of clinically manifested complications which might result in death. The aim of the study was to assess the prevalence of subclinical target organ damage in hypertensive patients with OSA, and to establish whether these lesions are dependent on the intensity of sleep-disordered breathing. Materials and method. The study covered 67 patients with OSA diagnosed on the basis of polygraphy. Depending on the apnea/hypopnea index (AHI), the patients were divided into two groups: G1 (n=32; AHI=5-30) and G2 (n=35; AHI>30). The control group C consisted of 31 hypertensive subjects with OSA risk estimated as low based on the Berlin Questionnaire (BQ). Each patient had the following parameters measured: intima-media thickness (IMT), ankle-brachial index (ABI), left ventricular mass index (LVMI), and estimated glomerular filtration rate (eGFR). Results. The patients with severe OSA had significantly higher LVMI compared to the control group (130.99±44.6 g/m 2 versus 106.61±27.86 g/m 2 ; p=0.0332). The G2 group had higher eGFR than C (104.7±17.96 ml/min/1.73m 2 , 88.85±17.68 ml/min/1.73m 2 ; p=0.0058). Similar results of eGFR were observed between G1 and C (104.35±21.06 ml/min/1.73m 2 , 88.85±17.68 ml/min/1.73m 2 ; p=0.0081). G1 and G2 did not differ significantly in terms of eGFR. The other measured parameters, such as IMT and ABI, did not differ significantly between OSA and controls. Conclusions. Patients with severe OSA demonstrate signs of left ventricular hypertrophy, while early atherosclerotic lesions (ABI and IMT) were not more intense than in the control group. High eGFR levels may indicate hyperfiltration, which does not correlate with OSA intensity level.

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“…Right heart (RH) failure or dysfunction can occur in pre-existing pathologies such as obstructive sleep apnoea, chronic obstructive pulmonary disease, pulmonary hypertension or acute onset of new disease in the critically ill patients [ 117 , 121 , 130 , 131 ]. In addition, ventilation can be an induce RH decompensation.…”

Section: Echocardiographymentioning

confidence: 99%

Imaging Evaluation of Pulmonary and Non-Ischaemic Cardiovascular Manifestations of COVID-19

et al. 2021

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Coronavirus Disease 2019 (COVID-19) has been a pandemic challenge for the last year. Cardiovascular disease is the most described comorbidity in COVID-19 patients, and it is related to the disease severity and progression. COVID-19 induces direct damage on cardiovascular system, leading to arrhythmias and myocarditis, and indirect damage due to endothelial dysfunction and systemic inflammation with a high inflammatory burden. Indirect damage leads to myocarditis, coagulation abnormalities and venous thromboembolism, Takotsubo cardiomyopathy, Kawasaki-like disease and multisystem inflammatory syndrome in children. Imaging can support the management, assessment and prognostic evaluation of these patients. Ultrasound is the most reliable and easy to use in emergency setting and in the ICU as a first approach. The focused approach is useful in management of these patients due its ability to obtain quick and focused results. This tool is useful to evaluate cardiovascular disease and its interplay with lungs. However, a detailed echocardiography evaluation is necessary in a complete assessment of cardiovascular involvement. Computerized tomography is highly sensitive, but it might not always be available. Cardiovascular magnetic resonance and nuclear imaging may be helpful to evaluate COVID-19-related myocardial injury, but further studies are needed. This review deals with different modalities of imaging evaluation in the management of cardiovascular non-ischaemic manifestations of COVID-19, comparing their use in emergency and in intensive care.

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Galectin-3 and neutrophil-to-lymphocyte ratio are indicative of heart remodelling and disease severity in patients with obstructive sleep apnoea

Cited by 11 publications

References 47 publications

Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation

Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation

Prevalence of target organ damage in hypertensive patients with coexisting obstructive sleep apnea

Imaging Evaluation of Pulmonary and Non-Ischaemic Cardiovascular Manifestations of COVID-19

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