Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation

Wałek, Paweł; Grabowska, Urszula; Cieśla, Elżbieta; Sielski, Janusz; Roskal-Wałek, Joanna; Wożakowska−Kapłon, Beata

doi:10.3390/biom11081108

Cited by 9 publications

(3 citation statements)

References 45 publications

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“…However, the combination of circulating biomarkers reflecting excessive myocardial collagen type-I cross-linking and deposition shows a predictive effect on higher AF prevalence, incidence, and recurrence after ablation ( 122 ). In addition, a negative correlation was described between galectin-3 and echocardiographic parameters assessing the LA, including LA volume and LA strain rate ( 123 ). ST-2 and apoptotic microparticles are also associated with increased LA volume index ( 124 ).…”

Section: Biomarkersmentioning

confidence: 99%

Left Atrial Cardiomyopathy – A Challenging Diagnosis

Kreimer

Gotzmann

2022

Front. Cardiovasc. Med.

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Left atrial cardiomyopathy (LACM) has been an ongoing focus of research for several years. There is evidence that LACM is responsible for atrial fibrillation and embolic strokes of undetermined sources. Therefore, the correct diagnosis of LACM is of clinical importance. Various techniques, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, computed tomography, electroanatomic mapping, genetic testing, and biomarkers, can both identify and quantify structural, mechanical as well as electrical dysfunction in the atria. However, the question arises whether these techniques can reliably diagnose LACM. Because of its heterogeneity, clinical diagnosis is challenging. To date, there are no recommendations for standardized diagnosis of suspected LACM. However, standardization could help to classify LACM more precisely and derive therapeutic directions to improve individual patient management. In addition, uniform diagnostic criteria for LACM could be important for future studies. Combining several parameters and relating them seems beneficial to approach the diagnosis of LACM. This review provides an overview of the current evidence regarding the diagnosis of LACM, in which several potential parameters are discussed and, consequently, a proposal for a diagnostic algorithm is presented.

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Section: Biomarkersmentioning

confidence: 99%

Left Atrial Cardiomyopathy – A Challenging Diagnosis

Kreimer

Gotzmann

2022

Front. Cardiovasc. Med.

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“…There is a link between the severity of atrial remodeling and the onset of subsequent AF episodes as well as the progression from paroxysmal to persistent AF [ 1 ]. By assessing the stage of atrial remodeling, it is possible to predict the efficacy of DCCV in patients with persistent AF [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Left Atrial Wall Motion Velocity Assessed during Atrial Fibrillation Predicts Sinus Rhythm Maintenance after Electrical Cardioversion in Patients with Persistent Atrial Fibrillation

Wałek

Roskal-Wałek

Dłubis

et al. 2022

IJERPH

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Reduced left atrial wall motion velocity measured during AF (LAWMV) indicates left atrial remodeling. The aim of this study was to investigate whether LAWMV assessed with tissue Doppler imaging during atrial fibrillation (AF) predicts sinus rhythm (SR) maintenance after direct current cardioversion (DCCV) for persistent AF. The study included 126 patients who underwent DCCV and were followed for 12 months. At 12 months, maintained SR was reported in 55 patients (43.7%). We noted that LAWMV was higher in patients with maintained SR at 12 months than in those with recurrent AF (3.69 ± 0.84 vs. 2.86 ± 1.09; p < 0.001). In the multivariable regression model containing echocardiographic variables, LAWMV was an independent predictor of SR maintenance at 12 months (odds ratio [OR] 1.72, 95% confidence interval [CI] 1.1–2.69; p = 0.017). Similarly, LAWMW was an independent predictor of SR maintenance at 12 months (OR 1.81, 95% CI 1.19–2.77; p = 0.006) in the multivariate regression model containing both echocardiographic and clinical variables. LAWMV predicts SR maintenance after DCCV for persistent AF. Echocardiographic markers of left atrial mechanical remodeling are better at predicting SR maintenance than markers of structural remodeling.

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“…Wałek et al wrote “SerumGalectin-3 Concentration Reflects Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation” [ 8 ]. Atrial fibrillation (AF) is the most common persistent supraventricular tachyarrhythmia [ 9 ].…”

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confidence: 99%