Prevalence of target organ damage in hypertensive patients with coexisting obstructive sleep apnea

Myśliński, Wojciech; Szwed, Monika; Szwed, Jakub; Panasiuk, Lech; Brożyna-Tkaczyk, Klaudia; Borysowicz, Magdalena; Mosiewicz, Jerzy

doi:10.26444/aaem/149469

Cited by 2 publications

(2 citation statements)

References 22 publications

(25 reference statements)

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“…In the same line, studies by Altin et al ( 35 ) and Wang et al ( 36 ) described an association of cIMT with severe OSA and AHI. Conversely, Myśliński et al ( 37 ) described absence of differences in early lesions between severe OSA patients and healthy controls. However, patients with COPD have increased vascular damage compared to healthy subjects.…”

Section: Discussionmentioning

confidence: 97%

Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques

Landete

Fernández-García²,

Muñoz³

et al. 2023

Front. Cardiovasc. Med.

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BackgroundLittle is known about whether the overlap syndrome (OS) combining features of chronic obstructive pulmonary disease (COPD) and sleep apnea-hypopnea syndrome increases the risk of stroke associated with COPD itself.MethodsWe prospectively studied 74 COPD patients and 32 subjects without lung disease. Spirometry and cardiorespiratory polygraphy were used to assess the pulmonary function of the study population and ultrasound measurements of intima media thickness (IMT) as well as the volume of plaques in both carotid arteries were also evaluated.ResultsPolygraphic criteria of OS were met in 51% of COPD patients. We found that 79% of patients with OS and 50% of COPD patients without OS had atherosclerotic plaques in the left carotid artery (p = 0.0509). Interestingly, the mean volume of atherosclerotic plaques was significantly higher in the left carotid artery of COPD patients with OS (0.07 ± 0.02 ml) than in those without OS (0.04 ± 0.02 ml, p = 0.0305). However, regardless of the presence of OS, no significant differences were observed in both presence and volume of atherosclerotic plaques in the right carotid artery of COPD patients. Adjusted-multivariate linear regression revealed age, current smoking and the apnea/hypopnea index (OR = 4.54, p = 0.012) as independent predictors of left carotid atherosclerotic plaques in COPD patients.ConclusionsThis study suggests that the presence of OS in COPD patients is associated with larger left carotid atherosclerotic plaques, indicating that OS might be screened in all COPD patients to identify those with higher risk of stroke.

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Section: Discussionmentioning

confidence: 97%

Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques

Landete

Fernández-García²,

Muñoz³

et al. 2023

Front. Cardiovasc. Med.

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“…Patients with OSA may present with a variety of symptoms, including habitual snoring, fatigue, poor sleep quality, excessive daytime sleepiness (EDS), memory loss, headaches, and psychological disturbances ( 3 ). Many studies have confirmed that untreated OSA can damage multiple systems and organs and cause a variety of complications, including cardiovascular diseases, ischemic stroke, metabolic-related diseases, and neuropsychiatric complications ( 4 – 7 ).…”

Section: Introductionmentioning

confidence: 99%

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

Tao,

Dong,

et al. 2024

Front. Endocrinol.

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BackgroundObstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with normal blood pressure have not been fully defined.MethodsThis study retrospectively analyzed OSA patients diagnosed for the first time in Lihuili Hospital Affiliated to Ningbo University from 2016 to 2020. Patients were divided into an OSA group with hypertension and an OSA group without hypertension. The sociodemographic information, clinical symptoms, comorbidities, and polysomnography results of the two groups were compared. The independent risk factors associated with hypertension in patients with OSA were explored.ResultsA total of 1108 patients with OSA initially diagnosed were included in the study, including 387 with hypertension and 721 without. Compared with OSA patients without hypertension, OSA patients with hypertension were older; had a higher body mass index (BMI) and Epworth sleepiness score (ESS); a higher incidence of nocturia; and a higher proportion of diabetes mellitus, coronary heart disease, and cerebrovascular disease. Multivariate analysis showed age (odds ratio [OR]:1.06, 95% confidence interval [CI]:1.04-1.08), BMI (OR:1.17, 95% CI:1.11-1.23), ESS score (OR:0.97, 95%CI: 0.94-1.00) and nocturia symptoms (OR:1.64, 95% CI:1.19-2.27) was independently associated with hypertension in OSA patients, and comorbid diabetes (OR: 3.86, 95% CI: 2.31-6.45), coronary heart disease (OR: 1.90, 95% CI:1.15-3.16), and ischemic stroke (OR: 3.69,95% CI:1.31-10.40) was independently associated with hypertension in OSA patients.ConclusionCompared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease.

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Prevalence of target organ damage in hypertensive patients with coexisting obstructive sleep apnea

Cited by 2 publications

References 22 publications

Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques

Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

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