Galectin-3 – A jack-of-all-trades in cancer

Newlaczyl, Anna U.; Yu, Lu‐Gang

doi:10.1016/j.canlet.2011.09.003

Cited by 300 publications

(260 citation statements)

References 57 publications

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“…MCF-7-MGAT4A-KD cells showed a pronounced increase in nuclear galectin-3 by fluorescence microscopy. Nuclear galectin-3 plays a range of biological roles, including manipulation of RNA splicing and enhancement of transcription factor activity (46,47). Nuclear galectin-3 also plays a role in late-G 1 cell cycle arrest and suppression of anoikis, the programmed cell death in response to loss of cell adhesion (34,35).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression

Vaiana¹,

Kurćon

Mahal

2016

Journal of Biological Chemistry

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MicroRNA regulation of protein expression plays an important role in mediating many cellular processes, from cell proliferation to cell death. The human microRNA miR-424 is up-regulated in response to anti-proliferative cytokines, such as transforming growth factor ␤ (TGF␤), and directly represses cell cycle progression. Our laboratory recently established that microRNA can be used as a proxy to identify biological roles of glycosylation enzymes (glycogenes). Herein we identify MGAT4A, OGT, and GALNT13 as targets of miR-424. We demonstrate that MGAT4A, an N-acetylglucosaminyltransferase that installs the ␤-1,4 branch of N-glycans, is directly regulated by miR-424 in multiple mammary epithelial cell lines and observe the loss of MGAT4A in response to TGF␤, an inducer of miR-424. Knockdown of MGAT4A induces cell cycle arrest through decreasing CCND1 levels. MGAT4A does not affect levels of ␤-1,6 branched N-glycans, arguing that this effect is specific to ␤-1,4 branching and not due to gross changes in overall N-linked glycosylation. This work provides insight into the regulation of cell cycle progression by specific N-glycan branching patterns.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression

Vaiana¹,

Kurćon

Mahal

2016

Journal of Biological Chemistry

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“…Nuclear galectin-3 has been reported to function as an mRNA splicing promoter (5). When expressed on the surface of tumor cells, galectin-3 has a role as an adhesion molecule in cell-to-cell or cell-to-matrix interactions (6). Circulating galectin-3 has been reported to be produced by activated macrophages, mast cells, eosinophils and tumor cells (7).…”

Section: Introductionmentioning

confidence: 99%

Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer

et al. 2016

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“…The cell-and tissue-specific profiles of Galectin-3 expression differ under physiological and pathological conditions (14,109,110); they can undergo a variety of changes under the stress conditions encountered in tumour microenvironments, inflammation or fibrosis. Divergent specificities and affinities of Galectin-3 for various glycoproteins appear to contribute to the multiplicity of its activities.…”

Section: Expert Opinionmentioning

confidence: 99%