The Two Faces of Galectin-3: Roles in Various Pathological Conditions

Radosavljević, Gordana; Pantic, Jelena; Jovanović, Ivan; Lukic, Miodrag L.; Arsenijević, Nebojša

doi:10.1515/sjecr-2016-0011

Cited by 9 publications

(7 citation statements)

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“…Gal-3 can be expressed in cytoplasm, nucleus, mitochondria, and cell surface, and it can also be secreted by macrophages and monocytes and other various cell types into the extracellular matrix and circulation ( 12 , 13 ). Intracellular Gal-3 can be transported to the cell surface or even secreted outside of cells and depending on localization Gal-3 could act as positive or negative regulator of apoptosis [reviewed in ( 14 )]. We postulated that extracellular Gal-3 is most important in interaction that leads to inflammation, as shown in lipopolysaccharide induced neuroinflammation ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis

et al. 2018

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Schizophrenia and treatment of this disorder are often accompanied with metabolic syndrome and cardiovascular issues. Alterations in the serum level of innate immune mediators, such as interleukin-33 (IL-33) and its receptor IL-33R (ST2) and Galectin-3 (Gal-3) were observed in these conditions. Moreover, these parameters are potential prognostic and therapeutic markers. There is also accumulating evidence that these molecules play a role in neuroinflammation. Therefore, in this study we have investigated the serum level of Gal-3, IL-33 and soluble ST2 (sST2) in different stages of schizophrenia. Gal-3 levels were elevated in remission and lower in schizophrenia exacerbation in comparison with controls. Levels of IL-33 and sST2 are higher in schizophrenia exacerbation in comparison with controls and patients in remission. This initial analysis of new markers of neuroinflammation suggested their involvement in schizophrenia pathophysiology and/or cardiometabolic comorbidity.

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Section: Introductionmentioning

confidence: 99%

IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis

et al. 2018

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“…Binding of Gal-3 to the polygalactosyl repeats of Leishmania leads to truncation of Gal-3 by their surface major protease, gp63. The truncated Gal-3 cannot oligomerize or form stable Gal-3 association (9). Galectin-3 interacts with Trypanosoma cruzi by binding three specific proteins of the parasite.…”

Section: Role Of Galectin-3 In Inflammationmentioning

confidence: 99%

Galectin-3: multiple clinical applications

Kisheva

Yotov

2019

Biomedical Reviews

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Galectin-3 is a β-galactoside binding lectin, containing carbohydrate-recognition domain, which interacts with a number of ligands. It is found in many tissues and is distributed intra-and extracellularly. The localization of the biomarker determines its function. Galectin-3 is involved in variety of biological processes sush as inflammation, fibrosis, immunological response and neoplastic growth. It may be used as a diagnostic or prognostic biomarker especially in cancer and cardiovascular diseases. The present review summarizes some of the properties of this biomarker.

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“…8,9 Galectin-3 (Gal-3) is а soluble β-galactoside binding lectine that plays an important role in the modulation of fibrosis, inflammation and immune responses. 10,11 It is a well-known biomarker for risk stratification and prognostication in heart failure (HF) patients, but the data about the role of Gal-3 in AF are sparse. Some studies have shown that high circulating Gal-3 levels correlate with the degree of atrial fibrosis 12 and predict incident AF 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 in patients with atrial fibrillation and restored sinus rhythm

Kisheva¹,

Yotov²,

Chervenkov³

et al. 2021

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Introduction: Cardiac fibrosis is the hallmark of atrial remodeling in atrial fibrillation. Galectin-3 (Gal-3) is a biomarker of fibrosis. It is well studied in heart failure, but the data about its role in atrial fibrillation are sparse.Aim: The aim of the study was to evaluate the levels of Gal-3 in patients with atrial fibrillation after sinus rhythm restoration, to examine the association between this biomarker and other factors for developing atrial fibrillation and to assess its prognostic role.Materials and methods: We included 67 patients (35 male) at the mean age of 67.36±7.25 years, with Gal-3 test after sinus rhythm restoration, a subgroup of participants in placebo-controlled randomized clinical trial of treatment with spironolactone. They were followed up for atrial fibrillation recurrence and hospitalizations. The effect of demographic parameters and other factors on Gal-3 levels were evaluated before and one year after treatment.Results: Mean Gal-3 at baseline was 16.9±6.8 ng/ml. Higher levels of Gal-3 were associated with female gender (р=0.008), increasing age (р=0.005), renal dysfunction (p<0.0001) and gout (р=0.002). Higher thromboembolic risk as assessed by CHA2DS2-VASc score was significantly related to Gal-3. The levels of biomarker did not affect the number of atrial fibrillation recurrences (p=0.9) and hospitalizations. No correlation was found with treatment with spironolactone, antiarrhythmic and antihypertensive drugs.Conclusions: Higher Gal-3 in atrial fibrillation was associated with female sex, renal dysfunction, and history of gout. The levels of Gal-3 were not related to rhythm control. Treatment with spironolactone did not affect the biomarker of fibrosis Gal-3 in AF patients. Higher Gal-3 was related to high embolic risk.

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The Two Faces of Galectin-3: Roles in Various Pathological Conditions

Abstract: Galectin-3, a unique chimaera-type member of the lectin family, displays a wide range of activities. is versatile molecule is involved in fundamental biological

Cited by 9 publications

References 106 publications

IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis

IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis

Galectin-3: multiple clinical applications

Galectin-3 in patients with atrial fibrillation and restored sinus rhythm

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