Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer

Shimura, Tatsuo; Shibata, Masahiko; Gonda, Kenji; Nakajima, Takahiro; Chida, Shun; Noda, Masaru; Suzuki, Satoshi; Nakamura, Izumi; Ohki, Shinji; Takenoshita, Seiichi

doi:10.3892/br.2016.696

Cited by 27 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum galectin-3 levels were significantly associated with IL-17, but not IL-23 in patients with colorectal cancer ( 153 ). Shimura et al ( 152 ) also confirmed the serum galectin-3 levels was associated with IL-17 production. Furthermore, it was also inversely associated with the production of IL-10 and IL-12 ( 152 ).…”

Section: Galectin-3 and Cancermentioning

confidence: 84%

“…Shimura et al ( 152 ) also confirmed the serum galectin-3 levels was associated with IL-17 production. Furthermore, it was also inversely associated with the production of IL-10 and IL-12 ( 152 ). These results indicated that galectin-3 may be a key factor in the regulation of tumor-associated inflammatory processes.…”

Section: Galectin-3 and Cancermentioning

confidence: 84%

“…Furthermore, increased serum galectin-3/-4 expression levels at the time of primary tumor removal in patients without clinically detectable metastases were associated with poorer survival rates over the next 10 years ( 151 ). Increased serum galectin-3 expression levels were observed in patients with colon cancer when compared in patients with rectal cancer ( 152 ). No association was identified between tissue galectin-3 expression levels and clinicopathological parameters of patients with colorectal cancer, whereas the level of tissue galectin-3 expression was positively associated with serum IL-17 and IL-23.…”

Section: Galectin-3 and Cancermentioning

confidence: 99%

See 2 more Smart Citations

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

et al. 2017

View full text Add to dashboard Cite

Galectin-3 is a member of the galectin family, which are β-galactoside-binding lectins with ≥1 evolutionary conserved carbohydrate-recognition domain. It binds proteins in a carbohydrate-dependent and -independent manner. Galectin-3 is predominantly located in the cytoplasm; however, it shuttles into the nucleus and is secreted onto the cell surface and into biological fluids including serum and urine. It serves important functions in numerous biological activities including cell growth, apoptosis, pre-mRNA splicing, differentiation, transformation, angiogenesis, inflammation, fibrosis and host defense. Numerous previous studies have indicated that galectin-3 may be used as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease and cancer. With emerging evidence to support the function and application of galectin-3, the current review aims to summarize the latest literature regarding the biomarker characteristics and potential therapeutic application of galectin-3 in associated diseases.

show abstract

Section: Galectin-3 and Cancermentioning

confidence: 84%

Section: Galectin-3 and Cancermentioning

confidence: 84%

Section: Galectin-3 and Cancermentioning

confidence: 99%

See 1 more Smart Citation

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

et al. 2017

View full text Add to dashboard Cite

show abstract

“…8, 9 [Aguilar D et al ARIC unpublished data] Galectin-3 also plays a role in the regulation of immunological, inflammatory, and nutritional conditions, many of which are associated with atherosclerosis. 10 Some experimental studies in mice have shown that galectin-3 activity is modifiable through the use of inhibitors. 11, 12 Understanding whether galectin-3 is associated with atherosclerosis, in humans, might help in the development of new methods to detect early atherosclerosis, in the assessment of atherosclerotic burden, or in the development new treatments aimed at slowing down the progression of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Plasma Galectin-3 and Sonographic Measures of Carotid Atherosclerosis in the Atherosclerosis Risk in Communities Study

Oyenuga

Folsom

Fashanu³

et al. 2018

Angiology

View full text Add to dashboard Cite

Galectin-3 is a β-galactoside-binding lectin that plays a role in the regulation of several conditions that are associated with atherosclerosis. The goal of this cross-sectional study was to assess the association of plasma galectin-3 concentrations with sonographic measures of carotid atherosclerosis in the Atherosclerosis Risk in Communities study. Linear regression was used to determine the difference and 95% confidence intervals (CIs) for carotid intima-media thickness (cIMT) by categorical and continuous representations of galectin-3. Logistic regression was used to determine the odds ratio and 95% CI, separately, for dichotomized cIMT (75th percentile = 0.9 mm) and carotid plaque and/or shadowing. Compared to those in the first quintile of galectin-3, those in the fifth quintile of galectin-3 level had higher cIMT (mean difference: 0.020 mm after multivariable adjustment; P trend = .04). Moreover, compared to those in the lowest galectin-3 quintile, those in the highest galectin-3 quintile had higher odds of carotid plaque/and or shadowing (odds ratio 1.13 after multivariable adjustment; P trend = .014). Higher levels of galectin-3 are associated with greater carotid atherosclerosis. Our findings provide support for the role of inflammatory biomarkers in the pathogenesis of atherosclerosis and suggest galectin-3 as a possible target for intervention in the prevention or management of atherosclerotic disease.

show abstract

“…Although there was no correlation between serum galectin-3 levels and TNM stage clinically, we observed its correlation with N and advanced stages. Shimura et al showed that the correlation between galectin-3 and TNM stage was one of the key factors in the regulating immunological, inflammatory and nutritional factors in CRC [ 28 ]. In the present study, the patient survival was correlated with high serum galectin-3 levels (≥1.2ng/ml).…”

Section: Discussionmentioning

confidence: 99%

Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis

Huang

Yeh

et al. 2017

Oncotarget

View full text Add to dashboard Cite

In this study, we investigated the role of galectin-3 and carcinoembryonic antigen (CEA) in metastasis and survival of colorectal cancer (CRC) patients. CEA interacted with galectin-3 at the cell surface and cytoplasm of Caco2 and DLD1 CRC cells. Knocking down galectin-3 did not affect CEA expression in CRC cells. However, there was a dose-dependent increase in CRC cell migration upon addition of small amounts of exogenous CEA (≤1ng/ml). Galectin-3 knockdown blocked induction of CRC cell migration by CEA, suggesting interaction between galectin-3 and CEA was necessary for CRC cell migration. Exogenous CEA and galectin-3 synergistically promoted migration of galectin-3 knockdown DLD1 cells. Immunohistochemical analysis showed that CEA co-localized with galectin-3 in CRC patient tissues. In additon, advanced stage CRC patients had higher serum galectin-3 and CEA levels than early stage CRC patients. High serum CEA and galectin-3 levels correlated with advanced N stage and poor survival in CRC patients. These findings suggest interaction between galectin-3 and CEA promotes CRC migration and metastasis, and correlates with poor survival of CRC patients. Thus combinatorial therapy targeting galectin-3 and CEA may improve outcomes for advanced stage CRC patients.

show abstract

Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer

Cited by 27 publications

References 38 publications

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

Plasma Galectin-3 and Sonographic Measures of Carotid Atherosclerosis in the Atherosclerosis Risk in Communities Study

Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis

Contact Info

Product

Resources

About