Galactosylated fluorescent labeled micelles as a liver targeting drug carrier

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

“…54 Lactobionic acid (LA), comprising gluconic acid and Gal moiety, is the common ligand for hepatoma-targeted delivery. [55][56][57] The Gal residues on drug delivery system can recognize and bind specifically to the ASGPR on the hepatoma cells, 58,59 thus they facilitate drug delivery into the cells, which are inhibited and killed by therapeutic agents in delivery vehicles. Zhong's group developed a series of Gal-directed hepatoma-targeting delivery system to enhance the accumulation of anticancer drugs into and antitumor activity toward hepatoma cells.…”

Multifunctional Polymeric Nano-Carriers in Targeted Drug Delivery

“…Furthermore, galactosamine functionalized NPs were found much effective in tumor growth suppression and confi rmed the specifi c liver targeting potential of galactosamine functionalized nano-carriers via asialoglycoprotein receptor mediated endocytosis [ 200 ]. The concept of liver targeting by using galactose/galactosamine has been supported in a variety of reports for the delivery of all trans-retinoic acid by poly( L -lactic acid) NPs [ 201 ], gene delivery to hepatocytes by poly(ethylene glycol)-chitosan-graft-polyethylenimine [ 202 ], fl uorescent labeled micelles as a liver targeting drug carrier [ 203 ]. Although this strategy was found quite effective in liver targeting, reduced density and activity of ASGP receptors in patients with liver disease due to reduced binding capability of ASGP receptors may limit its use.…”

Target-Specific Cellular Uptake of Folate-Decorated Biodegradable Polymer Micelles

“…15À17 Consequently, tumor-selective strategies via cellular receptors in targeted gene and drug delivery is very necessary. 18,19 Conjugation of targeting molecules to block polymers such as folic acid (FA), 20 RGD peptide, 21 mannose, 22 and galactose 23 has been studied. Among these targeted molecules, FA is a popular choice which is employed as a targeting moiety of various anticancer agents to avoid their nonspecific attacks on normal tissues as well as to increase their cellular uptake within targeted cells.…”