Target-Specific Cellular Uptake of Folate-Decorated Biodegradable Polymer Micelles

Zhou, Qi; Guo, Xing; Chen, Tao; Zhang, Zhao; Shao, Shijun; Luo, Chao; Li, Jinrong; Zhou, Shaobing

doi:10.1021/jp207951e

Cited by 44 publications

(27 citation statements)

References 41 publications

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“…Block copolymer mPEG–CL X was synthesized through ring‐opening polymerization (ROP) of ε‐CL in bulk using mPEG as an initiator and SnCl 2 as catalyst according to our previous report 38. Typically, preweighed mPEG, ε‐CL monomer, and catalyst were added into a fresh flamed round‐bottomed flask.…”

Section: Methodsmentioning

confidence: 99%

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Zhang

et al. 2013

Macromolecular Bioscience

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Fluorescein isothiocyanate (FITC), a fluorescent probe, is coupled to amphiphilic monomethoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) copolymers. FITC-labeled mPEG-PCL copolymers self-assemble into micelles through the solvent evaporation method. The cellular internalization is examined using fluorescence microscopy on incubation of NIH-3T3 fibroblasts with micelles or free FITC solution. The effect of the hydrophilic/hydrophobic ratio on the endocytosis mechanisms is evaluated by fluorescence microscopy on culturing of human hepatoblastoma cells and human umbilical vein endothelial cells, individually, mixed with the micelles holding the same parameters including micelle size, shape, and surface charges.

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Section: Methodsmentioning

confidence: 99%

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Zhang

et al. 2013

Macromolecular Bioscience

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“…This could be explained by the fact that the free FA molecules occupying the folate receptors on MCF-7 cell membranes hinder the cellular internalization of FA-P127 into MCF-7 cells. 35 The results of the experiment conducted to investigate the competition between free FA and FA-P127 specifically showed that …”

Section: In Vitro Cellular Uptake Of Micellesmentioning

confidence: 99%

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Hao¹,

Tong²,

Jin³

et al. 2017

IJN

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A folic acid (FA)-functionalized drug vehicle platform based on Pluronic 127 (P127)/D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles was orchestrated for an effective delivery of the model drug resveratrol in order to address the problem of poor water solubility and rapid metabolism of resveratrol and improve its targeted accumulation at tumor site. The FA-decorated mixed micelles were prepared using thin-film hydration method and optimized by central composite design approach. The micelles were also characterized in terms of size and morphology, drug entrapment efficiency and in vitro release profile. In addition, the cytotoxicity and cell uptake of the micelles were evaluated in folate receptor-overexpressing MCF-7 cell line. In vivo pharmacokinetic and biodistribution studies were also performed. The average size of the micelles was ~20 nm with a spherical shape and high encapsulation efficiency (99.67%). The results of fluorescence microscopy confirmed the targeting capability of FA-conjugated micelles in MCF-7 cells. FA-modified micelles exhibited superior pharmacokinetics in comparison with that of solution. Further, the low accumulation of resveratrol-loaded FA micelles formulation in the heart and kidney avoided toxicity of these vital organs. It could be concluded that folate-modified P127/TPGS mixed micelles might serve as a potential delivery platform for resveratrol.

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“…M A N U S C R I P T ACCEPTED MANUSCRIPT 4 waals interactions, and hydrogen bonding. As a drug carrier, β-CD not only facilitates solubilization, stabilization, and transport of hydrophobic drugs, but also minimizes the unwanted side effects associated with the corresponding drugs.…”

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confidence: 99%

Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery

Ding

Shen

Sun

et al. 2015

Materials Science and Engineering: C

178

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Target-Specific Cellular Uptake of Folate-Decorated Biodegradable Polymer Micelles

Cited by 44 publications

References 41 publications

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery

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Target-Specific Cellular Uptake of Folate-Decorated Biodegradable Polymer Micelles

Cited by 44 publications

References 41 publications

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells

Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-&alpha;-tocopheryl polyethylene glycol 1000 succinate mixed micelles

Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery

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Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles