Multifunctional Polymeric Nano-Carriers in Targeted Drug Delivery

Agrawal, Ashish Kumar; Urimi, Dileep; Jain, Sanyog

doi:10.1007/978-3-319-11355-5_15

Cited by 6 publications

(3 citation statements)

References 210 publications

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“…In the field of functional food, nano-capsule technology was used to embed functional factors in functional foods, which can not only reduce the loss of functional factors during processing or storage, but also effectively deliver functional factors to the gastrointestinal tract of the human body [66][67][68][69]. The specific targeting of nano-capsules can change the distribution of functional factors and concentrate them in specific target tissues to achieve the purpose of reducing toxicity and improving efficacy, and they can improve their bioavailability by controlling the release of functional factors while maintaining the texture, structure, and sensory attractiveness of the food [70][71][72][73][74]. The wall materials of nano-capsules should meet the requirements of non-toxic, edible, good biocompatibility, and degradability in the food industry, and at the same time, the properties of core materials and wall materials and the application performance of microcapsules should be comprehensively considered [75].…”

Section: Nano-capsulementioning

confidence: 99%

Nano Functional Food: Opportunities, Development, and Future Perspectives

Zhao

Zhang

et al. 2022

IJMS

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A functional food is a kind of food with special physiological effects that can improve health status or reduce illness. However, the active ingredients in functional foods are usually very low due to the instability and easy degradation of some nutrients. Therefore, improving the utilization rate of the effective ingredients in functional food has become the key problem. Nanomaterials have been widely used and studied in many fields due to their small size effect, high specific surface area, high target activity, and other characteristics. Therefore, it is a feasible method to process and modify functional food using nanotechnology. In this review, we summarize the nanoparticle delivery system and the food nanotechnology in the field of functional food. We also summarize and prospect the application, basic principle, and latest development of nano-functional food and put forward corresponding views.

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Section: Nano-capsulementioning

confidence: 99%

Nano Functional Food: Opportunities, Development, and Future Perspectives

Zhao

Zhang

et al. 2022

IJMS

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“…Polymeric micelles are nanometric amphiphilic colloidal nanocarriers composed of an interior hydrophobic core and an exterior hydrophilic surface, which undergo self-aggregation above CMC [ 247 ]. In diameter, the micelles range from 10 to 100 nm, which enables them to get accumulated in the tumor site via extravasation.…”

Section: Nanotechnology: Cavalry For Tnbc Therapymentioning

confidence: 99%

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

et al. 2022

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Triple-negative breast cancer (TNBC) is considered one of the un-manageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and metastasis, the management of TNBC remains a mainstay challenge, despite the advancements in cancer therapies. Conventional chemotherapy remains the only treatment regimen against TNBC and suffers several limitations such as low bioavailability, systemic toxicity, less targetability, and multi-drug resistance. Although various targeted therapies have been introduced to manage the hardship of TNBC, they still experience certain limitations associated with the survival benefits. The current research thus aimed at developing and improving the strategies for effective therapy against TNBC. Such strategies involved the emergence of nanoparticles. Nanoparticles are designated as nanocavalries, loaded with various agents (drugs, genes, etc.) to battle the progression and metastasis of TNBC along with overcoming the limitations experienced by conventional chemotherapy and targeted therapy. This article documents the treatment regimens of TNBC along with their efficacy towards different subtypes of TNBC, and the various nanotechnologies employed to increase the therapeutic outcome of FDA-approved drug regimens.

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“…However, chitosan itself has weak antibacterial and antioxidant activities and poor water solubility, which cannot meet the demand for efficient development [18]. Chitosan quaternary ammonium salt (HACC) exhibited better water solubility and higher antibacterial activity than chitosan over the entire pH range [19], resulting in the increased potential of chitosan for drug release and antimicrobial applications [20], expanding the range of applications of chitosan [21]. On the one hand, it can provide a positive charge and react easily with negatively charged substances; on the other hand, the superb surface activity provides an easier dispersion for microcapsules, thereby reducing the agglomeration of microcapsules.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, Release and Antibacterial Properties of Cinnamon Essential Oil Microcapsules

Liu

Zhao

et al. 2023

Coatings

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In this study, the antibacterial microcapsules of cinnamon essential oil (CEO) were prepared by complex condensation method. Chitosan quaternary ammonium salt (HACC) combined with gum arabic (GA) was selected as the coated wall material. The optimal preparation conditions of CEO microcapsules (CMSs) were determined by response surface methodology (RSM): the core/wall mass ratio was 1:1, the pH value was 4.5, the mass concentration of CaCl2 was 0.7 wt% and the actual encapsulation rate of microcapsules was 90.72% ± 1.89%. The morphology, size, composition and thermal stability of the prepared CMSs were characterized by scanning electron microscopy (SEM), laser particle size analysis (LPDA), Fourier transform infrared spectroscopy (FTIR), thermogravimetric differential thermal analysis (TG–DTA) and differential scanning calorimetry (DSC). In addition, the in vitro drug release and antibacterial properties of CMS were also evaluated. The results showed that CMS was spherical, with an average particle size of 6.31 µm. The obvious weight loss occurred at 269 °C and the corresponding DSC curve had an obvious exothermic peak at 265.5 °C, which had an increase compared with CEO. Microcapsules can achieve slow release, with the lowest and highest release rates being 19.66% and 49.79%, within 30 days. The drug release curve of essential oil of microcapsules was consistent with a first-order release model named ExpDec1. Based on the above research results, the CMS can effectively improve the stability of essential oil, achieve slow release and prolong the antibacterial effect, indicating its potential applications in food, cosmetics and medicine.

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Multifunctional Polymeric Nano-Carriers in Targeted Drug Delivery

Cited by 6 publications

References 210 publications

Nano Functional Food: Opportunities, Development, and Future Perspectives

Nano Functional Food: Opportunities, Development, and Future Perspectives

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

Preparation, Characterization, Release and Antibacterial Properties of Cinnamon Essential Oil Microcapsules

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