Galactomannan from Caesalpinia spinosa induces phenotypic and functional maturation of human dendritic cells

Santander, Sandra Paola; Aoki, Mikio; Hernández, John Fredy; Pombo, Marina A.; Mooney, Nuala; Fiorentino, Susana

doi:10.1016/j.intimp.2011.01.006

Cited by 40 publications

(26 citation statements)

References 41 publications

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“…In our work, brief incubation (3 h) with Scb or βGM induced a slightly activation of DC observed by an up-regulation of mRNA for TNFα and CCR7 coreceptor (Figure 4). Recently, Santander et al [48] described that long exposure (~48 h) to βGM from Caesalpinia spinosa plant extracts induce phenotypic maturation of human DC characterized by CD83, CD86, CD206 and HLA-DR and increase mRNA for IL1β, IL6, CXCL8 and IL12p70 cytokines.…”

Section: Discussionmentioning

confidence: 99%

Effect of Saccharomyces cerevisiae var. Boulardii and beta-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)

Badía

Zanello

Chevaleyre

et al. 2012

Vet Res

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Probiotic and prebiotics, often called "immune-enhancing" feed additives, are believed to deal with pathogens, preventing the need of an immune response and reducing tissue damage. In this study, we investigated if a recently developed β-galactomannan (βGM) had a similar protective role compared to Saccharomyces cerevisiae var. Boulardii (Scb), a proven probiotic, in the context of enterotoxigenic Escherichia coli (ETEC) infection. ETEC causes inflammation, diarrhea and intestinal damage in piglets, resulting in large economic loses worldwide. We observed that Scb and βGM products inhibited in vitro adhesion of ETEC on cell surface of porcine intestinal IPI-2I cells. Our data showed that Scb and βGM decreased the mRNA ETEC-induced gene expression of pro-inflammatory cytokines TNF-α, IL-6, GM-CSF and chemokines CCL2, CCL20 and CXCL8 on intestinal IPI-2I. Furthermore, we investigated the putative immunomodulatory role of Scb and βGM on porcine monocyte-derived dendritic cells (DCs) per se and under infection conditions. We observed a slight up-regulation of mRNA for TNF-α and CCR7 receptor after co-incubation of DC with Scb and βGM. However, no differences were found in DC activation upon ETEC infection and Scb or βGM co-culture. Therefore, our results indicate that, similar to probiotic Scb, prebiotic βGM may protect intestinal epithelial cells against intestinal pathogens. Finally, although these products may modulate DC activation, their effect under ETEC challenge conditions remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Effect of Saccharomyces cerevisiae var. Boulardii and beta-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)

Badía

Zanello

Chevaleyre

et al. 2012

Vet Res

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“…22 It also stimulates phagocytosis and macrophages proliferation. 23,24 Some cell immune subsets mobilization / proliferationhave been also observed in 12-weeks treated Humans using a fenugreek extract (Furosap TM ). 25 This event might bring substantial explanation for the observed mobilization of immune cell lineages in our work.…”

Section: Discussionmentioning

confidence: 98%

Some biological effects of Trigonella foenum- graecom L, in healthy men

Ben-Nasr¹,

Bouzidi²,

Gharbi³

et al. 2018

EMIJ

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Fenugreek (Trigonella foenumm-graecum L.) is widely used against several diseases. It owned great interest because it contains numerous biologically active substances. In this work, the in vivo effect of fenugreek seeds' intake on hemodynamic, blood sugar level and hematological parameters was evaluated in healthy volunteers. Ten healthy volunteer men were included in the experiment. Their overnight fasting blood sugar level, hemodynamic and hematological parameters were measured before, and one hour after the intake of 10 g of powdered fenugreek seeds in a water suspension. The T-paired test showed significant decrease in the arterial blood pressure (from 9,2 ± 0,65 to 8,43 ± 0,31cmHg for the mean arterial pressure; and 7,8 ± 1,03 to 6,7 ± 0,67cmHgfor the arterial diastolic pressure) and heart frequency (from 77,3 ± 3,23 to 75,40 ± 3,37 bits/min), and an increase in total white blood cell (8,24 ± 2,29and 9,16± 2,20.10 3 /µL; p ≤0,01) and granulocytes (5,26± 1,94 to 5,70 ± 1,86 .10 3 /µL, p ≤0,01) counts, one hour after fenugreek seeds intake. In addition the overnight-fasting blood sugar level was diminished from 5,71 ± 0,37 to 5,37± 0,44 mmol/L, at p ≤ 0,001.The present work demonstrates the potential anti-hypertensive and anti-hyperglycemic effects of fenugreek seeds, and may support its use as alternate remedy against these chronic pathologies but cautions its application before conducting specific allergic tests .

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“…ex Havil. Santander et al (2011) also enhanced the expressions of CD1a, CD38, CD40, CD54, CD80, CD83, CD86, HLA-DR and CCR7 on DCs, and the production of IL-12 in DCs partially through TLR4 and TLR2. Uncarinic acid C-primed DC stimulated naïve T cells into typical Th1 cells that produced large quantities of IFN-γ depending on IL-12 secretion, enhanced the T cell stimulatory capacity in an allogeneic MLR and CTL (K.S.…”

Section: Other Components Of Chmmentioning

confidence: 88%

“…In human Mo-DCs, purified Galactomannan from Caesalpinia spinosa (Molina) Kuntze induced phenotypic maturation and proinflammatory cytokines, decreased antigen uptake in Galactomannanstimulated DCs and increased alloantigen presentation capacity (Santander et al, 2011).…”

Section: Polysaccharide Of Chmmentioning

confidence: 99%

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Zhang

2015

Journal of Ethnopharmacology

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Galactomannan from Caesalpinia spinosa induces phenotypic and functional maturation of human dendritic cells

Cited by 40 publications

References 41 publications

Effect of Saccharomyces cerevisiae var. Boulardii and beta-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)

Effect of Saccharomyces cerevisiae var. Boulardii and beta-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)

Some biological effects of Trigonella foenum- graecom L, in healthy men

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

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