The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Li, Jinyao; Li, Jinyu; Zhang, Fuchun

doi:10.1016/j.jep.2015.05.050

Cited by 57 publications

(26 citation statements)

References 127 publications

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“…For instance, in the Indian Ayurveda system of medicine, E. angustifolia is known as an immunomodulator to treat respiratory conditions. Similarly, in the traditional Chinese medicine, E. purpurea is named Song Guo Ju and is prescribed to prevent and treat upper respiratory tract infections (Kumar et al, 2012;J. Li, Li, & Zhang, 2015;Lü et al, 2015;Patwardhan & Gautam, 2005).…”

Section: The Genus Echinacea In Traditional Medicinementioning

confidence: 99%

Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications

Sharifi‐Rad

Mnayer

Morais-Braga

et al. 2018

Phytotherapy Research

129

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The genus Echinacea consists of 11 taxa of herbaceous and perennial flowering plants. In particular, Echinacea purpurea (L.) Moench is widely cultivated all over the United States, Canada, and in Europe, exclusively in Germany, for its beauty and reported medicinal properties. Echinacea extracts have been used traditionally as wound healing to improve the immune system and to treat respiratory symptoms caused by bacterial infections. Echinacea extracts have demonstrated antioxidant and antimicrobial activities, and to be safe. This survey aims at reviewing the medicinal properties of Echinacea species, their cultivation, chemical composition, and the potential uses of these plants as antioxidant and antibacterial agents in foods and in a clinical context. Moreover, the factors affecting the chemical composition of Echinacea spp. are also covered.

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Section: The Genus Echinacea In Traditional Medicinementioning

confidence: 99%

Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications

Sharifi‐Rad

Mnayer

Morais-Braga

et al. 2018

Phytotherapy Research

129

View full text Add to dashboard Cite

show abstract

“…Mature DCs secreted IL-12 direct the induction of Th1 responses and cytotoxic T lymphocytes (CTL) (Carreno et al, 2013;Macatonia et al, 1995). Moreover, mature DCs highly express CCR7, a chemokine receptor, which promotes DCs migration to the draining lymph node (LN) (Randolph, Angeli & Swartz, 2005) Therefore, DCs are pharmacological target of immunomodulatory agents including herbal medicines due to its critical role in the immune system (Chen et al, 2006;Li, Li & Zhang, 2015a).…”

Section: Introductionmentioning

confidence: 99%

“…Plant-derived polysaccharides have been drawn much attention due to their immunomodulatory activities and safety (Kikete et al, 2018;Li, Li & Zhang, 2015a). Accumulating evidence, including our own, has demonstrated that polysaccharides could enhance the immunity through activation of different targets, such as DCs and macrophages (Ferreira et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The immunostimulatory activity of polysaccharides fromGlycyrrhiza uralensis

Aipire

Mahabati

Cai

et al. 2020

PeerJ

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Background The enhancement of immunity is very important for immunocompromised patients such as cancer patients with radiotherapy or chemotherapy. Glycyrrhiza uralensis has been used as food and medicine for a long history. G. uralensis polysaccharides (GUPS) were prepared and its immunostimulatory effects were investigated. Methods Human monocyte-derived dendritic cells (DCs) and murine bone marrow-derived DCs were treated with different concentrations of GUPS. The DCs maturation and cytokine production were analyzed by flow cytometry and ELISA, respectively. Inhibitors and Western blot were used to study the mechanism of GUPS. The immunostimulatory effects of GUPS were further evaluated by naïve mouse model and immunosuppressive mouse model induced by cyclophosphamide. Results GUPS significantly promoted the maturation and cytokine secretion of human monocyte-derived DCs and murine bone marrow-derived DCs through TLR4 and down-stream p38, JNK and NF-κB signaling pathways. Interestingly, the migration of GUPS treated-DCs to lymph node was increased. In the mouse model, GUPS increased IL-12 production in sera but not for TNF-α. Moreover, GUPS ameliorated the side effect of cyclophosphamide and improved the immunity of immunosuppressive mice induced by cyclophosphamide. These results suggested that GUPS might be used for cancer therapy to ameliorate the side effect of chemotherapy and enhance the immunity.

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“…Accumulating evidence shows that TCM and its components have immunoregulatory effects, especially in the regulation of DC maturation. [13][14][15] Therefore, TCM is a good candidate pool to search adjuvants. Pleurotus ferulae is a kind of TCM and has various biological activities such as anti-oxidant, anti-tumor, and anti-microbial.…”

Section: Introductionmentioning

confidence: 99%

Pleurotus ferulaepolysaccharides improve the antitumor efficacy of therapeutic human papillomavirus dendritic cell-based vaccine

Aipire

Zhao

et al. 2018

Human Vaccines & Immunotherapeutics

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We previously found that Pleurotus ferulae polysaccharides (PFPS) improved the maturation and function of dendritic cells (DCs). In this study, we investigated the effects of PFPS on the antitumor efficacy of therapeutic human papillomavirus (HPV) DC-based vaccine. PFPS stimulated DCs pulsed with HPV E6/E7 peptides were used to treat tumor mice on day 5 & 12 (HPV + PFPS-DCs early) and day 12 & 19 (HPV + PFPS-DCs late) after TC-1 cell injection. Compared to control group, both HPV + PFPS-DCs early and HPV + PFPS-DCs late strategies significantly inhibited tumor growth, which was significantly correlated with the increased activation status of both CD4 + and CD8 + T cells, the decreased frequencies of myeloid-derived suppressor cells, and the induction of HPV-specific CD8 + T cell responses. The survival of tumor mice was also greatly improved by HPV + PFPS-DCs early. Moreover, HPV + PFPS-DCs early completely inhibited the growth of second challenged TC-1 cells in tumor free mice. The results showed that PFPS improved the antitumor efficacy of therapeutic HPV DC-based vaccine, suggesting that PFPS might be a potential adjuvant for DC-based vaccines. This study provides a potential strategy for developing the therapeutic DC-based vaccine against cervical cancer.

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The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Cited by 57 publications

References 127 publications

Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications

Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications

The immunostimulatory activity of polysaccharides fromGlycyrrhiza uralensis

Pleurotus ferulaepolysaccharides improve the antitumor efficacy of therapeutic human papillomavirus dendritic cell-based vaccine

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