Gaining biological perspectives from schistosome genomes

Gobert, Geoffrey N.; You, Hong; McManus, Donald P.

doi:10.1016/j.molbiopara.2014.07.007

Cited by 14 publications

(11 citation statements)

References 87 publications

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“…We know from current data that these parasites can harbor significant amounts of genetic variation, but we are only just beginning to understand how that variation could alter approaches to vaccine development. Gobert et al [25] recently called for an increased effort to place schistosome genomic elements into a more biologically functional perspective. We build upon this call and encourage the schistosome community to incorporate studies that will provide perspective on the variable nature of the schistosome’s functional biology.…”

mentioning

confidence: 99%

It’s All about Those Bases: The Need for Incorporating Parasite Genetic Heterogeneity into the Development of Schistosome Vaccines

2015

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confidence: 99%

It’s All about Those Bases: The Need for Incorporating Parasite Genetic Heterogeneity into the Development of Schistosome Vaccines

2015

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“…This change of paradigm from phenotypic cell to target-based approach will definitely contribute to the discovery of more suitable bioactive NPs to combat these parasites. For this, other molecular targets are still necessary and the use of the technology of RNA interference (RNAi) has been very helpful for target identification and validation (Grant 2007;Geldhof et al 2007;Grant e Behm, 2007;Yoshino et al 2010;Maule et al 2011;Dalzell et al 2012;Crowther et al 2014;Gosbert et al 2014;He et al 2018). Besides, the search for new potential targets must consider not only their importance in pathogen survival and/or virulence but also their Bdruggability^, which might impair their use in HTS (Crowther et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Bioactive compounds against neglected diseases isolated from macroalgae: a review

et al. 2018

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To survive in a very competitive environment, marine macroalgae had to evolve defense strategies, resulting in an enormous diversity of compounds from different metabolic pathways. These secondary metabolites have been explored by the pharmaceutical industries in order to generate new drugs to treat several diseases. Recent publications in drug research from natural sources have indicated algae as an interesting choice to provide novel drugs to fulfill this gap. This review highlights algal metabolites that showed bioactivities suggesting their potential against neglected diseases. Drug discovery for neglected diseases has been overlooked by the Big Pharmas, mainly because they affect poor people, most of them living in developing countries. Moreover, this review shows the commercial application of the most explored chemicals from algae such as terpenes, phenols, quinones, macrolides, alkaloids, lipids, chromones, and other related metabolites and an overview regarding the status of green extraction technologies for seaweeds and their concepts.

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“…En este estudio, el análisis molecular de C. mutabile se realizó amplificando parcialmente los genes cox1 y nad1, se ha demostrado que estos genes son marcadores genéticos de poblaciones para varias especies de digeneos como Fasciola hepatica (Linnaeus, 1758) y Schistosoma japonicum (Katsurada, 1904) (Mas-Coma et al 2009, Gobert et al 2014. En nuestro estudio, C. mutabile mostró una diferencia de nucleótidos de 4% y 3% para los genes cox1 y nad1, respectivamente.…”

Section: Discussionunclassified

Diagnóstico morfológico y molecular de Cyclocoelum mutabile (Trematoda: Cyclocoelidae) en el Perú

et al. 2018

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Cyclocoelum mutabile, un digeneo de la familia Cyclocoelidae, fue hallado parasitando los sacos aéreos de una polla de agua común (Gallinula chloropus), proveniente de alrededores del Refugio de Vida Silvestre Pantanos de villa, localizada en el distrito de Chorrillos en Lima, Perú. Un total de 7 parásitos fueron colectados e identificados por métodos morfológicos como C. mutabile. El diagnóstico fue confirmado por análisis molecular, amplificando los genes mitocondriales citocromo c oxidasa subunidad 1 (cox1) y deshidrogenasa NADH subunidad 1 (nad1). Las secuencias de nucleótidos de los aislados se compararon con secuencias previas de GenBank, y mostraron una similitud entre ellas (> 96%). Este hallazgo constituye el primer registro de C. mutabile para el Perú. Además, el trabajo realiza una breve descripción del parásito, así como la discusión de sus hospederos y distribución geográfica en Sudamérica.

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Gaining biological perspectives from schistosome genomes

Cited by 14 publications

References 87 publications

It’s All about Those Bases: The Need for Incorporating Parasite Genetic Heterogeneity into the Development of Schistosome Vaccines

It’s All about Those Bases: The Need for Incorporating Parasite Genetic Heterogeneity into the Development of Schistosome Vaccines

Bioactive compounds against neglected diseases isolated from macroalgae: a review

Diagnóstico morfológico y molecular de Cyclocoelum mutabile (Trematoda: Cyclocoelidae) en el Perú

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