Elatol promotes a delay in the cell cycle, probably in the G(1)/S transition, activating the apoptotic process and this could be responsible, at least in part, for the in-vivo effects observed. Taken together, the in-vitro and in-vivo experiments suggested that elatol has anti-tumour properties. Further studies should be conducted to clarify the mechanism of action.
Seven new (1-7) and seven previously reported (8-14) halogenated metabolites were isolated from the organic extract of the Brazilian red alga Laurencia catarinensis. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses, whereas the structure of metabolite 6 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of metabolite 1 was determined using the modified Mosher's method. The in vitro cytotoxicity of compounds 1-14 was evaluated against HT29, MCF7, and A431 cell lines.
-(Production of essential oils in plants of Mentha x piperita L. var. piperita (Lamiaceae) submitted to different light levels and nutrition of the substratum). Mentha x piperita L. var. piperita (mint pepper) is utilized due to the presence of essential oils, mainly because of the component menthol produced in glandular trichomes. The influence of light intensity and substratum fertility was evaluated on the amount produced and quality of the essential oil. The light intensities utilized were 100%, 70% and 50% of the total solar light and two levels of nutrition of the substratum were applied (forest soil and forest soil with addition of organic fertilizer. The high light intensity and the addition of fertilizer favored the growth in biomass, influencing in this sense the production of the essential oil per plant. The light intensity and the addition of fertilizer influenced the oil quality, showing the plants under full sun light and fertilization with higher menthol content than plants in shadow or without fertilization. Menthol was the major component of the essential oil.Key words -essential oils, growth, light intensity, organic fertilizer RESUMO -(Produção de óleos essenciais em plantas de Mentha x piperita L. var. piperita (Lamiaceae) submetidas a diferentes níveis de luz e nutrição do substrato). Mentha x piperita L. var. piperita (hortelã-pimenta) é bastante utilizada devido à presença de óleos essenciais, principalmente pelo componente mentol, produzidos nos tricomas glandulares. Foi avaliada a influência da intensidade de luz e da adubação do substrato na quantidade e qualidade do óleo essencial. As intensidades de luz utilizadas foram 100%, 70% e 50% da luz solar total e dois níveis de nutrição do substrato aplicados, solo de mata e solo de mata com adição de adubo orgânico. A alta intensidade de luz e a adubação favoreceram o crescimento em biomassa, influenciando no rendimento do óleo essencial por planta. A intensidade de luz e a adubação influenciaram na qualidade do óleo essencial, apresentando as plantas sob luz solar plena e adubadas apresentaram maior concentração relativa de mentol que plantas sombreadas ou sem adubo. O mentol foi o componente majoritário encontrado no óleo essencial.Palavras-chave -adubação, crescimento, intensidade de luz, óleos essenciais 1.Parte da dissertação de mestrado do primeiro autor, Programa de
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