Gabapentin for the treatment of carpal tunnel syndrome: a randomized controlled trial

Hui, Andrew; Wong, S. M.; Leung, Howan; Man, Bik Ling; Yu, Esther Yee Tak; Wong, Lawrence K.S.

doi:10.1111/j.1468-1331.2010.03261.x

Cited by 32 publications

(29 citation statements)

References 23 publications

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“…Gabapentin is used in a variety of neuropathic pain conditions such as diabetic neuropathy, post herpetic neuralgia, and spinal cord injury (Sabet et al 2017;Serpell 2002). The safety and tolerability of this drug were reported by researchers (Hui et al 2011). However, the studies on effects of gabapentin on nerve conduction studies have been limited.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gabapentin on nerve conduction studies in carpal tunnel syndrome

et al. 2018

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Background: The most common type of neuropathy in adults is carpal tunnel syndrome (CTS) which is caused by compression of the median nerve at the wrist. Methods: This quasi-experimental study was conducted to determine the efficacy of gabapentin on nerve conduction studies in patients with mild CTS. The patients with mild CTS were randomly allocated into two groups. Group A received naproxen alone (500 mg/day, orally) while group B received both gabapentin (100-300 mg) and naproxen (500 mg/day, orally) for two months. Sensory nerve conduction velocity (SNCV) and distal motor latency (DML) were performed at baseline and two months after treatment. Results: There were no significant differences between the two groups with regards to the outcome parameters before initiation of intervention. The SNCV and DML showed no significant improvements in group A (p>0.05), whereas for group B the SNCV and DML of the median nerve were significantly improved at two months after treatment (p<0.001). Conclusion: Gabapentin was found to be effective for SNCV and DML in patients with mild CTS over a two-month period.

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Section: Introductionmentioning

confidence: 99%

Effect of Gabapentin on nerve conduction studies in carpal tunnel syndrome

et al. 2018

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“…In all these trials gabapentin was found effective to reduce the symptoms in CTS. In contrast, in another randomized, double-blinded, placebo controlled trial by Hui et al, the mean reduction in symptom severity of patients using gabapentin (300-900mg/day) was not found significant when compared with placebo at eighth week [21]. This trial showed that gabapentin has no superiority over placebo.…”

Section: Discussionmentioning

confidence: 67%

“…There are a few studies evaluating the efficacy of gabapentin in CTS [17][18][19][20][21]. The results of these studies are conflicting.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of splint treatment or splint plus gabapentin treatment in idiopathic carpal tunnel syndrome

Mehmetoglu¹

2018

Ann Clin Anal Med

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Aim: The aim of the present study was to evaluate the efficiency of gabapentin treatment combined with splint application in idiopathic carpal tunnel syndrome (CTS) and to determine clinically and electroneurophysiologically if the combined treatment is superior to splint application alone. Material and Method: A total of 30 patients with a clinical and electroneurophysiological diagnosis of CTS were recruited to the study and randomized into two groups to receive combined treatment consisting of 1800 mg/day gabapentin and splint application or to use splint alone. Clinical assessments were performed at baseline, at month 1 and month 6. Patients were assessed by Visual Analogue Scale (VAS), Boston Carpal Tunnel Questionnaire (BCTQ), grip strength and electroneurophysiological studies; the treatment satisfaction was evaluated by a Lickert scale. Results: VAS-pain, -paresthesia scores were improved in both groups with no statistical difference between the groups. Grip strength and functional assessments were improved significantly only in the splint group. In electroneurophysiological studies, distal motor latency in the combined treatment group, sensory latency in splint group and sensory conduction velocity in both groups were improved significantly. Intergroup comparisons revealed significant improvement in combined treatment group only for sensory conduction velocity. Discussion: In conclusion, our study suggests that combination of splint and gabapentin is not superior to the splint alone in the treatment of CTS, except for median nerve sensory conduction velocity.

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“…Only a few small RCTs have specifically examined chronic neuropathic pain of the upper extremity after peripheral nerve injury, 7 burns, 8 or compression neuropathy. 9 A recent study investigated gabapentin for the treatment of carpal tunnel syndrome over an 8-week trial but found no difference in symptom reduction over placebo. 9 Based on current evidence, gabapentin and pregabalin are considered first-line treatment, along with certain antidepressants and topical lidocaine, for the treatment of neuropathic pain.…”

Section: Chronic Neuropathic Painmentioning

confidence: 98%

“…9 A recent study investigated gabapentin for the treatment of carpal tunnel syndrome over an 8-week trial but found no difference in symptom reduction over placebo. 9 Based on current evidence, gabapentin and pregabalin are considered first-line treatment, along with certain antidepressants and topical lidocaine, for the treatment of neuropathic pain. 10 Opioids and tramadol are considered second-line treatment.…”

Section: Chronic Neuropathic Painmentioning

confidence: 98%