2000
DOI: 10.1016/s0002-9149(99)00597-4
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G-33a mutation in the promoter region of thrombomodulin gene and its association with coronary artery disease and plasma soluble thrombomodulin levels

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Cited by 51 publications
(46 citation statements)
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“…Interestingly, both Ϫ33G/A mutations were found in Asians, pointing to a polymorphic site in this population. This idea was recently confirmed by Li et al, 18 who found a 15% frequency of this mutation in Han Chinese subjects of Mongolian origin. Moreover, Li et al also found evidence that the GϪ33A mutation was significantly associated with coronary artery disease.…”
supporting
confidence: 53%
“…Interestingly, both Ϫ33G/A mutations were found in Asians, pointing to a polymorphic site in this population. This idea was recently confirmed by Li et al, 18 who found a 15% frequency of this mutation in Han Chinese subjects of Mongolian origin. Moreover, Li et al also found evidence that the GϪ33A mutation was significantly associated with coronary artery disease.…”
supporting
confidence: 53%
“…Furthermore, it was demonstrated that this mutation is associated with CAD in Asian patients. 23 A recurring missense mutation in the TM coding sequence was also identified in the above screening investigation. This was a mutation predicting Ala25Thr substitution and its significance has been investigated subsequently in a large case-control study, Study of Myocardial Infarction Leiden (SMILE).…”
Section: Introductionmentioning
confidence: 90%
“…Exclusion criteria included (1) documented malignancy, rheumatoid arthritis, renal insufficiency (serum creatinine > 1.5 mg/dl or creatinine clearance < 50 ml/ min), and active infection; (2) acute myocardial infarction (or acute coronary syndrome with positive cardiac troponin) < 7 days. Coronary risk factors, defined elsewhere, 6 were reviewed in all study participants. All study subjects gave written informed consent.…”
Section: Study Populationmentioning
confidence: 99%
“…Accordingly, decreased expression and increased shedding of the membrane TM are expected to participate in the processes of vascular atherogenesis, remodeling, and thrombus formation. Plasma levels of soluble TM have been reported to correlate with peripheral atherosclerosis 4 and coronary artery disease 5,6 in humans. Percutaneous transluminal coronary angioplasty and coronary stenting have been widely used for decades in patients with coronary artery disease.…”
Section: Introductionmentioning
confidence: 99%