Elevation of the soluble thrombomodulin levels is associated with inflammation after percutaneous coronary interventions

Abstract

SummaryBackground: Thrombomodulin (TM) is an endothelial cell surface thrombin-binding protein with anticoagulation ability by thrombin-mediated activation of protein C. An increase of plasma soluble TM level is reported to be associated with severity and worse outcome of coronary artery disease.Hypothesis: This prospective study investigated the relation of the elevated levels of plasma soluble TM and inflammatory and myonecrotic markers in patients undergoing percutaneous coronary intervention (PCI).Methods: Plasma levels of soluble TM, C-reactive protein (CRP), and creatine kinase and its MB isoenzyme were measured before and after PCI in 100 patients undergoing PCIs.Results: Peak TM levels after PCIs were significantly higher than baseline (3.39 ± 1.63 vs. 2.90 ± 1.57 ng/ml, p < 0.001). The peak TM levels after PCIs correlated significantly with

Effect of the anti-oxidant probucol on soluble thrombomodulin (sTM) in hypercholesterolemic rabbits

“…The physiological role of sTM is still unclear. In various pathologic situations associated with endothelial dysfunction, the level of plasma sTM is elevated [9]. In the present study, the levels of plasma sTM and OX-LDL were higher in high-cholesterol group as compared with control group, reaching maximum at the fourteenth week, indicating an imbalance in the haemostatic endothelial function in parallel with the hypercholesterolemia.…”

Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent and exposed to pulsed ultrasound

“…Loss of membrane-bound thrombomodulin into the soluble pool is thought to be caused by mechanical disruption, neutrophil-derived proteases and by rhomboids, a family of intramembranous proteases (Lohi et al 2004). Quantification of sthrombomodulin has been previously used to measure endothelial damage from a variety of causes, including hypertension, atherosclerosis, percutaneous transluminal coronary angioplasty and vasculitis (Boffa and Karmochkine 1998;Chao et al 2004;Dohi et al 2003;Gando et al 2004Gando et al ,2005Hjerkinn et al 2005;Sakamaki et al 2003).…”

Soluble Thrombomodulin Levels are Related to Inflammation after Coronary Bypass Surgery

“…Increased sTM level has been associated with mortality in patients with trauma, acute respiratory distress syndrome, major surgery and sepsis, expressing a correlation with multiple organ failure [5][6][7]. Moreover, increased sTM in patients with atherosclerosis is a predictor of poor cardiovascular outcome and increased levels of sTM, C-reactive protein (CRP) and another inflammatory markers have been reported after percutaneous coronary interventions [15] and have been found to be a predictor of poor outcome in patients surviving acute coronary syndromes [4].…”