Fuzhuan brick tea polysaccharides serve as a promising candidate for remodeling the gut microbiota from colitis subjects in vitro: Fermentation characteristic and anti-inflammatory activity

Fu Brick Tea Polysaccharides Prevent Obesity via Gut Microbiota-Controlled Promotion of Adipocyte Browning and Thermogenesis

“…Fu brick tea was thoroughly crushed and was passed through a 60-mesh screen. The extraction method of FBTP was developed according to the reported method. , The crushed sample was mixed with 95% ethanol (1:20, w/v) and was properly stirred for 4 h at 70 °C to degrease. The degreased sample was then mixed with 2000 mL of water at 80 °C with sufficiently stirring for 4 h, and the supernatant was collected after centrifugation (4000 g , 5 min).…”

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

“…34,35 FBT has been extensively studied in recent decades for its beneficial effects on obesity and related diseases, and it has been convincingly demonstrated as a potentially beneficial adjuvant. 23,36,37 Based on our previous reports, the HFD-induced obese mouse Paper Food & Function model, which manifested higher bodyweight and dyslipidemia compared to the CD-fed mice, was again used to confirm the beneficial effects of FBT on hepatic steatosis and steatohepatitis associated with obesity. 26,27 The results showed that FBT significantly alleviated HFD-induced obesity and dyslipidemia reflected as lower bodyweight and improved serum levels of TC, TG, HDL-C, LDL-C, AST, ALT and GLU.…”

“…27 The regulatory effects of FBT on obesity, lipid metabolism, steatohepatitis, and inflammatory responses have also been extensively reported in association with the corresponding genetic and gut microbiota alterations. 24,25,37,61,62 After overall consideration of the FBT altered gene expressions, along with the gut microbiota, tryptophan metabolic profiles and a series of metabolic indicators such as liver PC : PE, PEMT activity and TC, TG, and IDO activity, it was rationally estimated that the AhR signal was evolved due to the beneficial effects of FBT on dyslipidemia, hepatic steatosis and steatohe-patitis in HFD-fed mice. Our results do not allow us to determine whether the ameliorative effects of FBT on hepatic steatosis and steatohepatitis were individually due to the altered gut microbiota and metabolites, or FBT itself, or a combination of both.…”

Advancement in Therapeutic Intervention of Prebiotic-Based Nanoparticles for Colonic Diseases

“… 46 , 47 In addition, dietary polysaccharides, as an important prebiotic resource, have been reported to alleviate colitis by regulating the composition of the gut microbiota. 48 Common functional oligosaccharides and polysaccharides with prebiotic effects are summarized in Table 1 .…”