Fu Brick Tea Polysaccharides Prevent Obesity via Gut Microbiota-Controlled Promotion of Adipocyte Browning and Thermogenesis

Abstract

The antiobesity efficacy and underlying mechanisms of polysaccharides extracted from Fu brick tea (FBTP) were investigated. An 8-week administration of FBTP dose-dependently inhibited increases in body weight and weights of the epididymal-, retroperitoneal- and inguinal-white adipose tissues and stimulated beige-fat development and brown adipose tissue-derived nonshivering thermogenesis in high-fat diet-induced obese mice. FBTP protected against obesity-associated abnormality in serum adiponectin and leptin, indicating its positive regulation of energy metabolism. FBTP reversed gut dysbiosis by enriching beneficial bacteria, for example, Lactobacillus, Parabacteroides, Akkermansia, Bifidobacterium, and Roseburia. Results from the fecal microbiota transplantation further confirmed that FBTP-induced microbial shifts contributed to adipose browning and thermogenesis, thereby alleviating host adiposity, glucose homeostasis, dyslipidemia, and its related hepatic steatosis. Our study demonstrates the great potential of FBTP with prebiotic-like activities in preventing diet-induced obesity and its related metabolic complications via gut microbiota-derived enhancement of fat burning and energy expenditures.

Polysaccharide from Ziyang Selenium-Enriched Green Tea Prevents Obesity and Promotes Adipose Thermogenesis via Modulating the Gut Microbiota

“…It was found that Se-GTP intervention significantly increased the total SCFA content in the colon contents of obese mice, and the contents of acetate, propionate, isobutyrate, butyrate, and valerate were all dramatically elevated. These results indicated that the gut microbiota can utilize Se-GTP to generate SCFAs and subsequently contribute to the treatment of obesity, which is in agreement with the foregoing studies. , Succinate accumulation has been evidenced to control activation of BAT thermogenesis and target adipose browning . The recent study indicated that dietary polysaccharide can be decomposed by the gut microbiota to generate pyruvate, and then, pyruvate will be further converted to succinate .…”

“…It is worth concerning that the identified Se-GTP-promoted bacteria such as Lactobacillus, Bif idobacterium, Bacteroides, and Akkermansia have shown great associations with circulating SCFAs in animal studies. 44,45 In order to further probe into the potential mechanism of Se-GTP against obesity and its interrelated metabolic disorders, the metabolites derived from the intestinal flora were analyzed by UPLC-QqQ-MS.…”

“…These results indicated that the gut microbiota can utilize Se-GTP to generate SCFAs and subsequently contribute to the treatment of obesity, which is in agreement with the foregoing studies. 19,45 Succinate accumulation has been evidenced to control activation of BAT thermogenesis and target adipose browning. 46 The recent study indicated that dietary polysaccharide can be decomposed by the gut microbiota to generate pyruvate, and then, pyruvate will be further converted to succinate.…”

“…It is worth concerning that the identified Se-GTP-promoted bacteria such as Lactobacillus , Bifidobacterium , Bacteroides , and Akkermansia have shown great associations with circulating SCFAs in animal studies. , In order to further probe into the potential mechanism of Se-GTP against obesity and its interrelated metabolic disorders, the metabolites derived from the intestinal flora were analyzed by UPLC-QqQ-MS. It was found that Se-GTP intervention significantly increased the total SCFA content in the colon contents of obese mice, and the contents of acetate, propionate, isobutyrate, butyrate, and valerate were all dramatically elevated.…”

Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites of HFD/STZ-induced type 2 diabetes rats

“…14 Fu brick tea polysaccharides (FBTP) have been demonstrated to be the main active components in FBT, which primarily consist of arabinose, rhamnose, galactose, mannose and galacturonic acid. 15 Oral FBTP might directly reach the large intestine through the upper digestive tract without being destroyed and exhibit prebiotic-like actions in affecting intestinal microbiota composition. 16 These evidences encouraged us to further investigate whether FBTP could alleviate T2DM by maintaining intestinal homeostasis.…”