Futuristic medical implants using bioresorbable materials and devices

Chatterjee, Suman; Saxena, M.; Padmanabhan, Deepak; Jayachandra, Mahesh; Pandya, Hardik J.

doi:10.1016/j.bios.2019.111489

Cited by 68 publications

(45 citation statements)

References 85 publications

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“…They are having transformative impact on health care and improving the quality of life for millions of people (2). Particularly, implantable devices for monitoring physiological parameters, such as temperature (3)(4)(5)(6)(7), blood pressure (4,(7)(8)(9)(10), glucose (11), and respiration (12), to inform an individual's health state are of great importance and interest for both the diagnostic and therapeutic procedures (9,13,14). These devices perform in vivo sensing and recording of relevant signals directly at the target locations for early diagnosis of health issues (15), allowing necessary interventions to be deployed at the onset of adverse events (1).…”

Section: Introductionmentioning

confidence: 99%

Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing

et al. 2021

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There has been increasing interest in wireless, miniaturized implantable medical devices for in vivo and in situ physiological monitoring. Here, we present such an implant that uses a conventional ultrasound imager for wireless powering and data communication and acts as a probe for real-time temperature sensing, including the monitoring of body temperature and temperature changes resulting from therapeutic application of ultrasound. The sub–0.1-mm3, sub–1-nW device, referred to as a mote, achieves aggressive miniaturization through the monolithic integration of a custom low-power temperature sensor chip with a microscale piezoelectric transducer fabricated on top of the chip. The small displaced volume of these motes allows them to be implanted or injected using minimally invasive techniques with improved biocompatibility. We demonstrate their sensing functionality in vivo for an ultrasound neurostimulation procedure in mice. Our motes have the potential to be adapted to the distributed and localized sensing of other clinically relevant physiological parameters.

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Section: Introductionmentioning

confidence: 99%

Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing

et al. 2021

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“…Polylactide/poly(lactic acid) (PLA) is a biodegradable and biobased aliphatic polyester derived from renewable sources such as corn, potato, and sugar cane. Due to biodegradability and biocompatibility (PLA is approved by US Food and Drug Administration for contact with human cells) the early applications of polylactide (or its copolymers with polyglycolides) involved surgical sutures, implants or drug formulations [ 1 , 2 , 3 , 4 , 5 ]. The use of PLA was initially limited to these biomedical applications due to its high cost and low availability.…”

Section: Introductionmentioning

confidence: 99%

Crosslinking of Polylactide by High Energy Irradiation and Photo-Curing

2020

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Polylactide (PLA) is presently the most studied bioderived polymer because, in addition to its established position as a material for biomedical applications, it can replace mass production plastics from petroleum. However, some drawbacks of polylactide such as insufficient mechanical properties at a higher temperature and poor shape stability have to be overcome. One of the methods of mechanical and thermal properties modification is crosslinking which can be achieved by different approaches, both at the stage of PLA-based materials synthesis and by physical modification of neat polylactide. This review covers PLA crosslinking by applying different types of irradiation, i.e., high energy electron beam or gamma irradiation and UV light which enables curing at mild conditions. In the last section, selected examples of biomedical applications as well as applications for packaging and daily-use items are presented in order to visualize how a variety of materials can be obtained using specific methods.

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“…Biosensors and bioelectronics characterized by the ability to fully or partially dissolve, disintegrate, or physically or chemically decompose in a controlled fashion in a working environment, can further enhance the applications of flexible devices. These biodegradable or bioresorbable systems would provide a "transient" function useful in a number of spheres of operation e.g., implantable devices, devices that minimize waste, and platforms for data security (Kang et al, 2018;Li et al, 2018;Chatterjee et al, 2019). Our objective in this work is to show that silk proteins can enable such flexible (bio)sensors without the need for either metallic electrodes or interconnects.…”

Section: Resultsmentioning

confidence: 99%

Use of Silk Proteins to Form Organic, Flexible, Degradable Biosensors for Metabolite Monitoring

et al. 2019

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The development of sustainable and degradable biosensors and bioelectronics has implications for implantable systems, as well in addressing issues of electronic waste. Mechanically flexible and bioresorbable sensors can find applications at soft biological interfaces. While devices typically use metallic and synthetic components and interconnects that are non-degradable or have the potential to cause adverse tissue reactions, the use of nature-derived materials and conducting polymers can provide distinct advantages. In particular, silk fibroin and sericin can provide a unique palette of properties, providing both structural and functional elements. Here, a fully organic, mechanically flexible biosensor in an integrated 3-electrode configuration is demonstrated. Silk sericin conducting ink is micropatterned on a silk fibroin substrate using a facile photolithographic process. Next, using a conducting polymer wire sheathed in silk fibroin, organic interconnects are used to form the electrical connections. This fully organic electrochemical system has competitive performance metrics for sensing in comparison to conventional systems, as verified by detection of a model analyte-ascorbic acid. The stability of the silk biosensor through biodegradation was observed, showing that the sensors can function for several days prior to failure. Such protein-based systems can provide a useful tool for biomonitoring of analytes in the body or environment for controlled periods of time, followed by complete degradation, as transient systems for various applications.

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Futuristic medical implants using bioresorbable materials and devices

Cited by 68 publications

References 85 publications

Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing

Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing

Crosslinking of Polylactide by High Energy Irradiation and Photo-Curing

Use of Silk Proteins to Form Organic, Flexible, Degradable Biosensors for Metabolite Monitoring

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Futuristic medical implants using bioresorbable materials and devices

Cited by 68 publications

References 85 publications

Application of a sub–0.1-mm 3 implantable mote for in vivo real-time wireless temperature sensing

Application of a sub–0.1-mm 3 implantable mote for in vivo real-time wireless temperature sensing

Crosslinking of Polylactide by High Energy Irradiation and Photo-Curing

Use of Silk Proteins to Form Organic, Flexible, Degradable Biosensors for Metabolite Monitoring

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Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing

Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing