Future possibilities for the treatment of septic shock with herbal components

Wang, Houli; Xu, Tianming; Lewin, Matthew R.

doi:10.1016/j.ajem.2008.08.003

Cited by 18 publications

(14 citation statements)

References 50 publications

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“…The inflammatory peritoneal processes promotes a “depletion syndrome" that can show signs of prostation (Qi), asthenia (Yin) and impairment (Yang), as a result of an infection. Thus, management of inflammatory peritoneal conditions using Chinese herbal medicine or acupuncture to treat the “depletion syndrome" could strengthen the immune system against infection by suppressing and/or neutralizing pathogens, as well as through the inhibition of inflammatory mediator production [7, 11, 19, 20]. Importantly, acupuncture is a traditional form of Chinese medicine that has been accepted and used worldwide for its effects on various physiological regulatory mechanisms and control of pathological changes.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Interleukin-10 in the Anti-Inflammatory Effect of Sanyinjiao (SP6) Acupuncture in a Mouse Model of Peritonitis

Silva

Guginski

Werner

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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In this study, we determined the anti-inflammatory effect of manual acupuncture at the Sanyinjiao or Spleen 6 (SP6) point on carrageenan-induced peritonitis in mice and investigated mechanisms that may underlie this effect. In the first set of experiments, male Swiss mice were allocated into five groups: the control (sterile saline), dexamethasone (DEXA), invasive sham-acupuncture (non-acupoint), SP6 acupuncture and carrageenan-treated groups. Ten minutes after needle retention or 30 min after DEXA treatment, mice received an intraperitoneal injection of carrageenan (750 μg/mouse). After 4 h, total leukocyte and differential cell counts (neutrophils and mononuclear), myeloperoxidase (MPO) activity, vascular permeability and cytokine levels were evaluated. In another set of experiments, adrenalectomized (ADX) mice were used to study the involvement of the adrenal gland on the therapeutic effects of acupuncture. Mice were allocated into two groups: the ADX and sham-operated animals (Sham ADX) that were subdivided into four subgroups each: the control (sterile saline), DEXA, SP6 acupuncture and carrageenan-treated groups. The SP6 and DEXA treatments inhibited the inflammatory cell infiltration, vascular permeability and MPO activity in carrageenan-injected mice. In addition, the SP6 treatment also increased interleukin (IL)-10 levels. In contrast, when the animals were adrenalectomized, the SP6 treatment failed to reduce total leukocyte and the plasma extravasation. In conclusion, this study clearly demonstrates the anti-inflammatory effect of SP6 acupuncture in a model of carrageenan-induced peritonitis. Our results demonstrated that SP6 acupuncture depends of the adrenal glands and increased IL-10 levels to produce its anti-inflammatory action.

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Section: Discussionmentioning

confidence: 99%

Involvement of Interleukin-10 in the Anti-Inflammatory Effect of Sanyinjiao (SP6) Acupuncture in a Mouse Model of Peritonitis

Silva

Guginski

Werner

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…1) LPS administration has shown to associate with overproduction of nitric oxide, tissue injury and organ failure. 2,3) Moreover, increasing LPS into blood circulation could induce a severe systemic inflammatory reaction implicated in pulmonary, hepatic and renal failures. 4) LPS administration could also cause a reduction of glomerular filtration rate (GFR), as commonly found in septic shock patients.…”

Section: Introductionmentioning

confidence: 99%

<i>Spirogyra neglecta</i> Aqueous Extract Attenuates LPS-Induced Renal Inflammation

Ontawong

Srimaroeng

Boonphang

et al. 2019

Biological & Pharmaceutical Bulletin

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Spirogyra neglecta (SN), commonly named "Tao" in Thai, is a genus of filamentous green macroalgae. SN contains polyphenols such as isoquercetin, catechin, hydroquinone and kaempferol. These constituents exhibit beneficial effects including anti-oxidant, anti-gastric ulcer, anti-hyperglycaemia and anti-hyperlipidaemia in both in vitro and in vivo models. Whether SN extract (SNE) has an anti-inflammatory effect in vivo remains unclear. This study examined the effect of SNE on renal function and renal organic transport in lipopolysaccharide (LPS)-induced renal inflammation in rats. Rats were randomised and divided into normal saline (NS), NS supplemented with 1000 mg/kg body weight (BW) of SNE (NS SNE), intraperitoneally injected with 12 mg/kg BW of LPS and LPS treated with 1000 mg/kg BW of SNE (LPS SNE). Biochemical parameters in serum and urine, lipid peroxidation concentration, kidney function and renal organic anion and cation transports were determined. LPS-injected rats developed renal injury and inflammation by increasing urine microalbumin, total malondialdehyde (MDA) and inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-1β protein expression, respectively. In addition, uptake of renal organic anion, [ 3 H]-oestrone sulphate (ES), was reduced in LPS-injected rats together with increased expression of organic anion transporter 3 (Oat3). However, the renal injury and inflammation, as well as impaired Oat3 function and protein expression, were restored in LPS SNE rats. Accordingly, SNE could be developed as nutraceutical product to prevent inflammation-induced nephrotoxicity.

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“…For a variety of reasons, renewed interests have been focused on studying and evaluating naturally existing products with long term therapeutic applications in critical patients [7,10,21,22]. Some traditional Chinese herbs examined with scientific rigor and modern technology in our lab or in other labs were shown to exert excellent anti-sepsis effects via probably direct antagonistic activities on LPS or CpG DNA [11,12,23].…”

Section: Discussionmentioning

confidence: 97%

“…They are focused and investigated with renewed interests and regarded as promising drug candidates in treating sepsis nowadays [6][7][8][9]. Some herbs were evaluated and reported to be with direct anti-LPS or anti-CpG DNA activities in previous studies [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii

Liu

Zheng

Long

et al. 2011

International Immunopharmacology

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Future possibilities for the treatment of septic shock with herbal components

Cited by 18 publications

References 50 publications

Involvement of Interleukin-10 in the Anti-Inflammatory Effect of Sanyinjiao (SP6) Acupuncture in a Mouse Model of Peritonitis

Involvement of Interleukin-10 in the Anti-Inflammatory Effect of Sanyinjiao (SP6) Acupuncture in a Mouse Model of Peritonitis

<i>Spirogyra neglecta</i> Aqueous Extract Attenuates LPS-Induced Renal Inflammation

Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii

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