Future manufacturing approaches in the chemical and pharmaceutical industry

Buchholz, Sigurd

doi:10.1016/j.cep.2010.08.010

Cited by 124 publications

(92 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is a well-known fact that continuous manufacturing is superior to batch processing owing to its cost effectiveness, robustness, better product quality control, and so on. Furthermore, continuous manufacturing meets the requirements of environmental protection and it can be more economical than a batch processing [34,35]. ES can perfectly fit into this perspective.…”

mentioning

confidence: 99%

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Szabó

Démuth

Nagy

et al. 2018

Express Polym. Lett.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Szabó

Démuth

Nagy

et al. 2018

Express Polym. Lett.

View full text Add to dashboard Cite

“…The filtration experiments were carried out in a standardized pressure Nutsche instrument (BHS Sonthofen GmbH) with a filtration area, A 1) , of 19.56 cm 2 . The amount of filtered suspension was varied, depending on different kinds of suspension preparation and mass fractions.…”

Section: Filtration Experimentsmentioning

confidence: 99%

“…This situation leads to competitive disadvantages because of the wide product range, as well as the constant changing market demand. To be capable of competing, the development of a production process, and thus, the large-scale production of the product, has to be considerably accelerated [1,2]. A promising way to enable this is the modularization of functional areas in process engineering [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Separation Characteristics of Crystalline Amino Acids with Regard to the Modularization Idea

et al. 2017

View full text Add to dashboard Cite

In the chemical and pharmaceutical industry, a fast and efficient market launch is important to withstand global competition. Apart from the innovation of new products, the development of an appropriate production line is time-consuming. Modularization can accelerate the design and commissioning of a production plant. Herein, representative of a pharmaceutical process, the production, precisely the solid-liquid separation, of amino acids is considered. Therefore, the separation behavior of different amino acid systems and variations within solid systems are examined. With this information, a production plant is designed and differences regarding the amino acid systems are identified.

show abstract

“…Over the last decade, the development of continuous manufacturing and purification processes, particularly crystallization, has mainly focused on the modification of existing batch units [8][9][10] , in addition to studying innovative equipment design. Batch crystallizers are often based around stirred-tank technologies, which can be converted to continuous mode as multi-stage mixed-suspension and mixed product removal (MSMPR) operations [11][12][13][14][15][16] , but they suffer from broad residence time distributions, leading to broad crystal size distributions and problems in downstream processes, such as filtration, isolation, drying and solids mixing.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Benyahia

Nagy

et al. 2015

Org. Process Res. Dev.

View full text Add to dashboard Cite

Just Accepted "Just Accepted" manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides "Just Accepted" as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. "Just Accepted" manuscripts appear in full in PDF format accompanied by an HTML abstract. "Just Accepted" manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). "Just Accepted" is an optional service offered to authors. Therefore, the "Just Accepted" Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the "Just Accepted" Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these "Just Accepted" manuscripts. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 TABLE OF CONTENTS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 The configuration in which anti-solvent could be added at a variety of different locations along the tube length and at optimal flow rates was able to outperform previous designs in the literature which considered equally-spaced anti-solvent additions. The use of dynamic models to detect problems during startup of an MSMA-PFC was also highlighted.

show abstract

Future manufacturing approaches in the chemical and pharmaceutical industry

Cited by 124 publications

References 7 publications

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Separation Characteristics of Crystalline Amino Acids with Regard to the Modularization Idea

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Contact Info

Product

Resources

About