Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Abstract

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Stem cell biomanufacturing under uncertainty: A case study in optimizing red blood cell production

“…Typical superstructure optimization applications are in industry; examples include: well scheduling in petroleum fields, crude oil scheduling in a petrochemical refinery, designing wastewater treatment systems, and crystallization . The purpose of Misener et al applying superstructure optimization to a stem cell bioreactor is simultaneously testing a range of design variables leading to different superstructure possibilities; the ANTIGONE algorithm resolves design choice tradeoffs …”

Design Space Identification and Visualization for Continuous Pharmaceutical Manufacturing

“…COBCs are another emerging technology, which enhance heat and mass transfer, but have issues handling streams with high solid loadings [26]. Various experimental and modeling studies have been conducted for the estimation of crystallization kinetics, proof-of-concept demonstrations and design and optimization processes [27][28][29][30][31][32].…”

Technoeconomic optimisation and comparative environmental impact evaluation of continuous crystallisation and antisolvent selection for artemisinin recovery

“…Crystallisation via solution cooling is a commonly used unit operation in many industries, including fine chemicals and pharmaceuticals. Crucial process parameters towards efficient purification and control over API crystal size distribution, morphology, and purity are heat and mass transfer, and these become even more important with the very high purity requirements and stringent quality specifications which are quintessential for pharmaceuticals (Su et al, 2015).…”