Future Horizons in Hair Restoration

Marshall, Bryan T.; Ingraham, Chris A.; Wu, Xunwei; Washenik, Ken

doi:10.1016/j.fsc.2013.05.005

Cited by 13 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The iPSC technology can also be used for disease modeling and drug development17. Differentiation of iPSCs to SE cells is the first step of realizing personalized regenerative medicine to reduce hair loss and to treat diseases related to SE-derived tissues, such as limbal stem cell deficiency that can lead to visual impairment and blindness18 and epidermolysis bullosa that causes blisters in the skin and mucosal membranes ranging in severity from mild to lethal192021. However, a reliable and efficient protocol for differentiating hiPSCs into SE has not yet been reported.…”

mentioning

confidence: 99%

Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

Zhou

Yang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Surface ectoderm (SE) cells give rise to structures including the epidermis and ectodermal associated appendages such as hair, eye, and the mammary gland. In this study, we validate a protocol that utilizes BMP4 and the γ-secretase inhibitor DAPT to induce SE differentiation from human induced pluripotent stem cells (hiPSCs). hiPSC-differentiated SE cells expressed markers suggesting their commitment to the SE lineage. Computational analyses using integrated quantitative transcriptomic and proteomic profiling reveal that TGFβ superfamily signaling pathways are preferentially activated in SE cells compared with hiPSCs. SE differentiation can be enhanced by selectively blocking TGFβ-RI signaling. We also show that SE cells and neural ectoderm cells possess distinct gene expression patterns and signaling networks as indicated by functional Ingenuity Pathway Analysis. Our findings advance current understanding of early human SE cell development and pave the way for modeling of SE-derived tissue development, studying disease pathogenesis, and development of regenerative medicine approaches.

show abstract

mentioning

confidence: 99%

Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

Zhou

Yang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Animal studies reveal creation of human follicles from cultured dermal and epidermal cells in a mouse model [37] . A revolutionary breakthrough in this field is the discovery of induced pluripotent stem cells enabling to reprogram differentiated fibroblasts into an embryonic stem cell state [38,39] . A recent study exhibits the creation of a bioengineered hair follicle germ using embryonic skin-derived epithelium and mesenchymal donor cells where the transplanted germ integrate to the host epithelium producing a complete functional hair [40] .…”

Section: Discussionmentioning

confidence: 99%

Evolution of hair transplantation

Kayıran¹,

Cihandide²

2018

PAR

View full text Add to dashboard Cite

Aim: Numerous non-surgical methods and surgical options are available for the solution of baldness in the practice. Technology provides mighty weapons in this field. Thus, individualized solutions are best carried out with well-trained and qualified practitioners. Here, a modification of follicular unit extraction, direct hair implantation is introduced with previously licensed unique pens. Methods: Follicular unit extraction and direct hair implantation methods were carried out in 207 hair transplantations between January and December of 2014. The nests for the grafts were created via pieces of hand-cut razor blade in follicular unit extraction. In addition, a new modification of follicular unit extraction, direct hair implantation, is done via pens that are produced for this purpose. Results: Thirty-eight direct hair implantations were performed in addition with 169 follicular unit extractions. An average number of 2973 grafts were transplanted. Mean operation time was calculated as 385 min. Conclusion: Hair transplantation is still the best solution for hair loss. In conjunction with the surgery, the addition of non-surgical interventions may give a better result to the patient. On the other hand, the promising results in the field of regenerative medicine with cell-based solutions may alter hair transplantation and change the options solely into this field.

show abstract

“…Hair transplantation or surgical hair restoration is widely employed by men with AGA. The introduction of robotic systems for HF harvesting has improved the technical function of this procedure [119,120]. Research efforts are underway to allow reconstituted HF to be transplanted as an alternative to harvested HF.…”

Section: Nondrug Therapiesmentioning

confidence: 99%

Drug discovery for alopecia: gone today, hair tomorrow

Santos

Avci

Hamblin

2015

Expert Opinion on Drug Discovery

View full text Add to dashboard Cite

Introduction Hair loss or alopecia affects the majority of the population at some time in their life, and increasingly, sufferers are demanding treatment. Three main types of alopecia (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]) are very different, and have their own laboratory models and separate drug-discovery efforts. Areas covered In this article, the authors review the biology of hair, hair follicle (HF) cycling, stem cells and signaling pathways. AGA, due to dihydrotesterone, is treated by 5-α reductase inhibitors, androgen receptor blockers and ATP-sensitive potassium channel-openers. AA, which involves attack by CD8+NK group 2D-positive (NKG2D+) T cells, is treated with immunosuppressives, biologics and JAK inhibitors. Meanwhile, CIA is treated by apoptosis inhibitors, cytokines and topical immunotherapy. Expert opinion The desire to treat alopecia with an easy topical preparation is expected to grow with time, particularly with an increasing aging population. The discovery of epidermal stem cells in the HF has given new life to the search for a cure for baldness. Drug discovery efforts are being increasingly centered on these stem cells, boosting the hair cycle and reversing miniaturization of HF. Better understanding of the molecular mechanisms underlying the immune attack in AA will yield new drugs. New discoveries in HF neogenesis and low-level light therapy will undoubtedly have a role to play.

show abstract

Future Horizons in Hair Restoration

Cited by 13 publications

References 39 publications

Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

Evolution of hair transplantation

Drug discovery for alopecia: gone today, hair tomorrow

Contact Info

Product

Resources

About