FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development

EGFR ligands synergistically increase IL‐17A‐induced expression of psoriasis signature genes in human keratinocytes via IκBζ and Bcl3

“…Abnormal EGFR activation affects skin repair and inflammation [10]. Previous studies have demonstrated that EGFR activation mediates keratinocyte proliferation and is involved in epidermal acanthosis during the development of psoriasis [32, 33]. In this study, we showed that EGFR ligands synergize with IL‐17A, a major effector cytokine driving the development of psoriasis [7, 34], to induce the production of various psoriasis signature genes in monolayer‐cultured keratinocytes and LSE.…”

Serum N‐glycan profiling as a diagnostic biomarker for the identification and assessment of psoriasis

“…The content of core‐fucosylated N ‐glycan enhances significantly in the process of tissue malignant evolution, considerably higher than in normal tissues 48 . Alpha‐(1,6)‐fucosyltransferase 8(FUT8) is implicated in the pathogenesis of several malignancies, Kelel M et al found the elevated FUT8 expression in the lesional epidermis is implicated in the development of psoriasis phenotypes, and FUT‐8 promotes the proliferation of epidermal keratinocytes through the EGFR/Akt signaling pathway by controlling the expression of cyclin, which highly expressed in the epidermal cells of patients with psoriasis and is related to the severity of the disease 49 . In the future, we will enrich the core fucoglycosylated serum total protein in healthy subjects and psoriasis patients with lens culinaris agglutinin (LCA) specifically binding core fucoglycosylated glycans.…”

“…48 Alpha-(1,6)-fucosyltransferase 8(FUT8) is implicated in the pathogenesis of several malignancies, Kelel M et al found the elevated FUT8 expression in the lesional epidermis is implicated in the development of psoriasis phenotypes, and FUT-8 promotes the proliferation of epidermal keratinocytes through the EGFR/Akt signaling pathway by controlling the expression of cyclin, which highly expressed in the epidermal cells of patients with psoriasis and is related to the severity of the disease. 49 In the future, we will enrich the core fucoglycosylated serum total protein in healthy subjects and psoriasis patients with lens culinaris agglutinin (LCA) specifically binding core fucoglycosylated glycans. Isobaric Tag for relative and absolute quantitation-time of flight(iTRAQ-TOF) will be used to further analyze the protein differences between the samples and to explore the specific glycoprotein markers that could contribute diagnosis of psoriasis, and fucosylated haptoglobin will be focused as one of the specific target glycoproteins.…”

Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases

“…Reduced levels of FUT7 CpG DNA methylation have been found in lung cancer, especially in LUSC ( 118 ), and FUT7 promotes lung cancer proliferation by activation of the EGFR/AKT/mTOR signal pathway ( 119 ). FUT8, whose expression is upregulated in most cancers, regulates the core fucosylation of PD-1 ( 120 , 121 ), PD-L2 ( 122 ), TGF-β ( 123 ), TNFR ( 124 ), EGFR ( 78 , 125 , 126 ), B7H3 ( 127 ), α3β1 integrin ( 128 ), and E-cadherin ( 129 ) as well as that of mucins ( 130 ). Upregulated expression of FUT8 in cancer-associated fibroblasts promotes the construction of an invasive tumor microenvironment in NSCLC through the core fucosylation of EGFR ( 78 ).…”