Further Studies on Toxicity of Thioacetamide in Rats

Bile acid excretion: the alternate pathway in the hamster.

“…Also, histological sections of the kidney at the time of sacrifice showed no evidence of cell necrosis in contrast to the liver, which revealed the lesions described previously by others (19,20).…”

“…Hepatic cell necrosis was induced by intraperitoneal injection of thioacetamide (20 mg/100 g body wt in 0.9% saline), a well-defined hepatotoxin that does not cause histological changes in other organs including the kidney (19). Animals on protein-depleted diets can develop elevation in urea nitrogen in serum in association with histologic renal lesions after several days of thioacetamide feeding (20).…”

Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis

“…In rats [21] cytochrome p-450 system is known to metabolize thioactamide in the liver. Formation of thioacetamide-5-oxide which is responsible for the changes in cell permeability, increase intracellular concentration of calcium, increase in nuclear volume and enlargement of nucleoli and also inhibit mitochondrial activity which leads to cell death [22,23,24]. As a result, the embryos exhibit steatohepatitis similar to that of observed in humans with nonalcoholic steaohepatitis.…”

Curative effect of <em>Plumbago indica</em> root extract on thioacetamide induced hepatotoxicity in experimental rats

“…TAA is an organic solvent with thiono sulfur components have been used widely to induce liver cirrhosis [23]. The mechanism of TAA toxicity is due to the formation of TAA-S-oxide, which is responsible for the change in cell permeability, increased intracellular concentration of Ca ++ , increase in nuclear volume and enlargement of nucleoli, and also inhibits the mitochondrial activity which leads to cell death [24]. In the present study, the administration of TAA significantly (P ≤ 0.05) elevated the levels of serum ALT, AST, ALP and LDH in rats treated with TAA.…”