Further Studies on the Intestinal Glucuronide Synthesis

Abstract

Summary.Intragastric feeding of cinchophen in dog results in a significant increase in the portal blood glucuronide concentration in addition to the rise in hepatic and femoral blood glucuronide contents. Ligation of the common bile duct does not prevent the increase in portal blood glucuronide concentration.These observations are taken as a further evidence to support our in vitro studies with tissue slices. These have shown that the mucous membrane of the gastrointestinal tract participates in the detoxication mechanisms and is capable to conjugate glucuronides with suitable substances present in the environment.

Urinary Glucuronic Acid Excretion in Liver Disease and the Effect of a Salicylamide Load

“…It does, however, suggest that the jaundice of Gilbert's disease may not be due to an inability to conjugate bilirubin with glucuronic acid, or that the defect may be intermittent, brought on by minor stresses and strains. Conjugation of salicylamide in these cases may not have occurred only in the liver; other possible sites include the kidney and, in dogs, the mucosa of the gastro-intestinal tract (Hartiala et al, 1958).…”