Summary.Intragastric feeding of cinchophen in dog results in a significant increase in the portal blood glucuronide concentration in addition to the rise in hepatic and femoral blood glucuronide contents. Ligation of the common bile duct does not prevent the increase in portal blood glucuronide concentration.These observations are taken as a further evidence to support our in vitro studies with tissue slices. These have shown that the mucous membrane of the gastrointestinal tract participates in the detoxication mechanisms and is capable to conjugate glucuronides with suitable substances present in the environment.
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