Urinary Glucuronic Acid Excretion in Liver Disease and the Effect of a Salicylamide Load

Abstract

NEW TECHNIQUE WITH HYDROXYDIONE MEDBLJO3RNL 337 is also recommended for caesarean section, thyroidectomy, and patients exhibiting partial respiratory obstruction.As was noted with the former methods of administering steroid anaesthesia, presuren minimizes the usual postoperative fatigue. It produces a sense of well-being during the recovery period, which enables patients to disregard most of the discomforts following operation.

Persistence of Antibiotics in Blood of Patients With Acute Renal Failure. Ii. Chloramphenicol and Its Metabolic Products in the Blood of Patients With Severe Renal Disease or Hepatic Cirrhosis*†

“…Thus, the defect noted in these patients was in the rate of conversion rather than in the total amount converted. Similar results have been reported in patients with liver disease given a salicylamide load (19). Such findings emphasize the need for determining the rate of glucuronide synthesis rather than the total amount synthesized.…”

Chronic Unconjugated Hyperbilirubinemia Without Overt Signs of Hemolysis in Adolescents and Adults*

“…The patients' serum was not more inhibitory than normal serum to the formation of directreacting bilirubin by rat liver slices. As indicated in Table IV (33,34). In other studies, however, after ingestion of menthol, patients with mild chronic unconjugated hyperbilirubinemia required a longer time than normal controls to excrete menthol glucuronide in the urine, although the total amount excreted during a 6-hour period was the same in both groups (57).…”

Intestinal Drug Absorption and Metabolism II: Kinetic Aspects of Intestinal Glucuronide Conjugation

“…The use of urinary excretion of drug glucuronides as an index of hepatic function is a common clinical procedure (19). It has recently been suggested that salicylamide would be an excellent choice for this purpose (20,21). It is possibly unwise, however, to use salicylamide, or any other drug which is largely glucuronylated in the intestine, as a measure of the ability of the liver to form glucuronides.…”