Further Studies on a Mixture of Fatty Acids from Sugar Cane (Saccharum officinarum) Wax Oil in Animal Models of Hypersensitivity

Abstract

A mixture of fatty acids obtained from sugar cane wax oil, the main components of which are palmitic, oleic, linoleic and linolenic acids, was evaluated topically in two experimental models of hypersensitivity: the ear swelling response to ovalbumin in sensitized mice (ED50 edema: 0.63 +/- 0.06 mg/ear, ED50 myeloperoxidase: 0.56 +/- 0.04 mg/ear, ED50 degranulated cells: 0.70 +/- 0,08 mg/ear) and oxazolone-induced contact hypersensitivity in mice (ED50 edema: 1.63 +/- 0.26 mg/ear, ED50 myeloperoxidase: 1.50 +/- 0.28 mg/ear, ED50 degranulated cells: 1.69 +/- 0.08 mg/ear). Also, the effect of this mixture was studied on the chemotaxis induced by fmlp (ED50: 25 +/- 3 microg/mL). The mixture showed anti-inflammatory activity in both in vivo models of allergy and in the chemotaxis test. Therefore, these results provide evidence about the potential usefulness of the mixture of fatty acids from sugar cane wax oil in cutaneous inflammatory and allergic disorders.

The Ethanol Extract of Holotrichia diomphalia Larvae, Containing Fatty acids and Amino acids, Exerts Anti-Asthmatic Effects through Inhibition of the GATA-3/Th2 Signaling Pathway in Asthmatic Mice

“…The relative content (mg/100 g) of each compound is listed in Table 1 and Table 2. Recently, evidence has been provided about the potent use of a mixture of fatty acids, in which the main components were oleic, linoleic, palmitic, and linolenic acids, for the treatment of cutaneous inflammatory and allergic disorders [9]. Fatty acids regulate immune responses, and it has been proved that they influence the incidence of IgE-mediated allergic disorders.…”

“…Our results were similar to those reported previously. A recent report has indicated that fatty acids can exert a beneficial effect on lung disease, including some types of asthma [8], and that a combination of fatty acids was a potential therapeutic material for cutaneous inflammatory disorders and allergies [9]. As HD can be used as an effective anti-inflammatory material, we hypothesized that HD could inhibit airway inflammation.…”