Effects of a mixture of fatty acids from sugar cane (Saccharum officinarum L.) wax oil in two models of inflammation: Zymosan-induced arthritis and mice tail test of psoriasis

Ledón, Nuris; Casacó, Á.; Remírez, Diadelis; González, Amnely; Cruz, Jonas Carneiro; González, Ricardo; Capote, Amelia; Tolón, Z.; Rojas, Erika Saalau; Rodríguez, Vargas; Merino, Nelsón; Rodríguez, S.; Ancheta, Odelsa; Cano, M.

doi:10.1016/j.phymed.2006.12.019

Cited by 19 publications

(11 citation statements)

References 17 publications

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“…These data indicate that HERP acts in both the central and peripheral nociception apart from inflammatory response, possibly due to a synergistic action of formononetin and other constituents present in the HERP. This similarity with the morphine effect was also observed by others (Ledón et al, 1997); the ethanolic extract of red propolis was effective in the hot plate test in mice.…”

Section: Figuresupporting

confidence: 87%

“…Other studies confirmed the anti-inflammatory activity of red propolis samples. For example, pharmacological evaluation of Cuban red propolis (Ledón et al, 1997), at a similar dosage, showed antiinflammatory activity in the cotton-pellet granuloma assay in rats, in croton oil-induced oedema in mice, in the peritoneal capillary permeability test in mice, and in the model of acetic acid-induced writings. Also, the isolated isoflavonoids vestiol and neovestiol, as well as the ethanolic extract of Brazilian red propolis, exhibited anti-inflammatory action by inhibiting neutrophil migration (Bueno-Silva et al, 2013), and the incorporation of Brazilian red propolis into collagen-based dressing films decreased the inflammatory severity and improved dermal burn healing (de Almeida et al, 2013).…”

Section: Figurementioning

confidence: 99%

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Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Cavendish

Santos

Neto

et al. 2015

Journal of Ethnopharmacology

121

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Section: Figuresupporting

confidence: 87%

Section: Figurementioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Cavendish

Santos

Neto

et al. 2015

Journal of Ethnopharmacology

121

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“…Three animals were used per dosage group. At the end of the treatment, the animals were killed by cervical dislocation, the tails were cut-off and longitudinal sections of tails were prepared and stained with haematoxylin for histological examination (Ledon et al, 2007) …”

Section: The Modified Mouse Tail Testmentioning

confidence: 99%

“…The change in epidermal thickness was then calculated. The percentage change in the epidermal thickness is often regarded to be representative of the extent to which a substance causes irritation (Ledon et al, 2007). …”

Section: Epidermal Thicknessmentioning

confidence: 99%

“…The antipsoriatic effect of A. wilkesiana and C. scandens as topical agents were evaluated using the modified albino mouse tail model (Bosman et al, 1992;Ledon et al, 2007) which had been used earlier to evaluate the effect of K. africana previously carried out in our lab (Oyedeji and Bankole-Ojo, 2012). The activity of K. africana reported was considered for comparative study and the data on the K. africana stem was used because of the high drug activity of this extract.…”

Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of the antipsoriatic activity of Acalypha wilkesiana, Culcasia scandens with Kigelia africana using the mouse tail model

Oyedeji¹,

Bankole-Ojo²

2017

Afr. J. Pure Appl. Chem.

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The mouse tail model was used to measure and compare antipsoriatic activity of Acalypha wilkesiana and Culcasia scandens with that of earlier reported Kigelia africana stem methanol extract by the same authors, with the objective of finding out which of these plant extracts can be a better drug option for the treatment of psoriasis. The results obtained showed that topically administered extracts (50-200 mg/ml) induced a significant and dose-dependent increase in %orthokeratosis in the epidermis of the mice tails. % orthokeratosis values were 35.5-43.4 (A. wikesiana), 29.7-47.4 (K. africana), 31.9-36.5 (C. scandens) for the methanol ointments; 29.3-36.2 (A. wikesiana), 32.3-58.2 (K. africana), 29.40-56.2 (C. scandens) for the hexane extracts. In general, the methanol extracts produced higher % othokeratosis. No deterioration in the general condition of the mice in any group was observed. However, erythema was observed on the tails of the mice on which the K. africana stem methanol extract ointment (200 mg/ml) was applied. No tail erythema was observed in any other group. Application of the ointments resulted in the softening of the tails. In general, the irritation potentials of the ointments were relatively low when compared to that induced by dithranol a drug commonly used in the treatment of psoriasis. Only the A. wilkesiana methanol extract ointment (200 mg/ml) showed greater than 40% drug activity. Thus, A. wilkesiana appears to be the better plant for use in possible drug development for the management and cure of psoriasis because A. wilkesiana ointment showed more prospects of being an antipsoriatic topical agent when compared to C. scandens or K. africana, as the drug activity of the methanol extract of this plant was greater than 40% and quite similar to that of K. africana without the corresponding irritation potential or erythema.

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Effects of sugar cane extract on steroidogenesis in testicular interstitial cells of male Japanese quail (Coturnix japonica)

Kobayashi

Mizu

et al. 2022

J Exp Zool Pt A

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Sugar cane extract (SCE) is the end product of glucose, fructose, and sucrose elimination in molasses. SCE has various biological effects, such as anti-inflammation and antioxidation, and it is commonly found in animal feed. The present research is aimed at investigating the reproductive endocrine influence of SCE in male Japanese quails (Coturnix japonica) by feeding SCE containing food. In addition, in vitro Leydig cell culture was conducted to clarify the mechanism of SCE's influence. Our results showed that SCE feed extended the latency to the first neck grab, decreased male quail testis and epididymis weights, cloaca gland size, and reduced serum testosterone concentrations. Steroidogenic enzymes 3βHSD, 17βHSD, P450c17, and P450scc gene expression in the testis were decreased in the SCE groups.Western blot analysis showed decreased 3βHSD in the testis after feeding SCE.Isolated testicular interstitial cells cultured with SCE and ovine-LH suppressed testosterone secretion and 3βHSD gene expression. In conclusion, SCE as a feed additive has an impact on the sexual behavior and reproductive function of male Japanese quail, with the suppression of steroidogenesis in the Leydig cell. Our results may provide beneficial information to the livestock management and the poultry industry.

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Effects of a mixture of fatty acids from sugar cane (Saccharum officinarum L.) wax oil in two models of inflammation: Zymosan-induced arthritis and mice tail test of psoriasis

Cited by 19 publications

References 17 publications

Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Comparative evaluation of the antipsoriatic activity of Acalypha wilkesiana, Culcasia scandens with Kigelia africana using the mouse tail model

Effects of sugar cane extract on steroidogenesis in testicular interstitial cells of male Japanese quail (Coturnix japonica)

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