Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Cavendish, Rodrigo Lima; Santos, Jandson de Souza; Neto, Reinaldo Belo; Paixão, Ailma Oliveira da; Oliveira, Juciele Valéria Ribeiro de; Araújo, Edilson Divino de; Silva, Andresa Aparecida Berretta e; Thomazzi, Sara Maria; Cardoso, Juliana Cordeiro; Gomes, Margarete Zanardo

doi:10.1016/j.jep.2015.07.022

Cited by 121 publications

(102 citation statements)

References 53 publications

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“…The chemical constituents present in propolis are responsible for its therapeutic properties [7, 11, 27], including its antibacterial, antifungal, and antiviral activities [5, 14] as well as its anti-inflammatory and antitumor activities [15, 16, 28, 29]. …”

Section: Discussionmentioning

confidence: 99%

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Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Bonamigo

Campos

Alfredo

et al. 2017

Oxidative Medicine and Cellular Longevity

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Propolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed to determine the chemical constituents as well as the antioxidant, cytotoxic, and toxic activities of ethanol extracts of propolis obtained from the stingless bees Scaptotrigona depilis and Melipona quadrifasciata anthidioides, which are found in Brazil. Phytosterols, terpenes, phenolic compounds, and tocopherol were identified in the ethanol extracts of propolis (EEPs) in different concentrations. The compounds stigmasterol, taraxasterol, vanilic acid, caffeic acid, quercetin, luteolin, and apigenin were found only in EEP-M. The EEPs were able to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and protected human erythrocytes against lipid peroxidation, with the latter effect being demonstrated by their antihemolytic activity and inhibition of malondialdehyde formation. The EEPs showed cytotoxic activity against erythroleukemic cells and necrosis was the main mechanism of death observed. In addition, the concentrations at which the EEPs were cytotoxic were not toxic against Caenorhabditis elegans. In this context, it is concluded that EEP-S and EEP-M show antioxidant and cytotoxic activities and are promising bioactive mixtures for the control of diseases associated with oxidative stress and tumor cell proliferation.

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Section: Discussionmentioning

confidence: 99%

“…The therapeutic activity of propolis from stingless bees has been widely investigated in recent decades, including descriptions of its antioxidant activity [10–12], antimicrobial activity [5, 13, 14], anti-inflammatory activity [15, 16], and antitumor activity [7, 12, 17]. …”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Bonamigo

Campos

Alfredo

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…However, studies about the synthesis of metallic nanoparticles using Brazilian propolis are not available yet. The red propolis is classified as the 13th Brazilian propolis group based on its physicochemical characteristics, in special the higher content of phenolic compounds, which gives a series of biological properties already reported in literature scaring properties, a stabilizer, antibacterial, anti‐inflammatory …”

Section: Introductionmentioning

confidence: 99%

“…The red propolis is classified as the 13th Brazilian propolis group based on its physicochemical characteristics, 16,17 in special the higher content of phenolic compounds, which gives a series of biological properties already reported in literature scaring properties, [18][19][20] a stabilizer, 14 antibacterial, [21][22][23][24] anti-inflammatory. 20,25,26 Given this information, the present study aimed to evaluate the biogenic synthesis of silver nanoparticles utilizing this Brazilian propolis.…”

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confidence: 99%

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Barbosa

Souza

Alvino

et al. 2019

Biotechnology Progress

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Biological methods have been used to synthesize silver nanoparticles through materials such as bacteria, fungi, plants, and propolis due to their reducing properties, stabilizer role and environmentally friendly characteristic. Considering the antimicrobial activity of propolis as well as the broad‐spectrum antibacterial effects of silver nanoparticles, this study aim to describe the use of Brazilian propolis to synthesize silver nanoparticles (AgNP‐P) and investigate its antimicrobial activity. The synthesis was optimized by factorial design, choosing the best conditions for smaller size particles. AgNP‐P demonstrated a maximum absorbance at 412 nm in ultraviolet‐visible spectra, which indicated a spherical format and its formation. Dynamic light scattering demonstrated a hydrodynamic size of 109 nm and polydispersity index less than 0.3, showing a good size distribution and stability. After its purification via centrifugation, microscopy analysis corroborates the format and showed the presence of propolis around silver nanoparticle. X‐ray diffraction peaks were attributed to the main planes of the metallic silver crystalline structure; meanwhile infrared spectroscopy demonstrated the main groups responsible for silver reduction, represented by ∼22% of AgNP‐P indicates by thermal analysis. Our product revealed an important antimicrobial activity indicating a synergism between propolis and silver nanoparticles as expected and promising to be an effective antimicrobial product to be used in infections.

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“…A study with formononetin, another isoflavonoid isolated from Brazilian red propolis, showed that administration of this compound in experimental inflammation models reduced carrageenan-induced leukocyte migration and edema formation21. In another study, it was found that genistein (largely found in soy) was able to prevent inflammation in rats.…”

Section: Discussionmentioning

confidence: 99%

Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6

Franchin

Colón

Cunha

et al. 2016

Sci Rep

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Isoflavonoids have been largely studied due to their distinct biological activities identified thus far. Herein, we evaluated the activity of neovestitol, an isoflavonoid isolated from Brazilian red propolis, in acute and chronic inflammation. As for acute inflammation, we found that neovestitol reduced neutrophil migration, leukocyte rolling and adhesion, as well as expression of ICAM-1 in the mesenteric microcirculation during lipopolysaccharide-induced acute peritonitis. No changes were observed in the levels of TNF-α, CXCL1/KC and CXCL2/MIP-2 upon pretreatment with neovestitol. The administration of an inducible nitric oxide synthase (iNOS) inhibitor abolished the inhibitory effects of neovestitol in neutrophil migration and ICAM-1 expression. Nitrite levels increased upon treatment with neovestitol. No effects of neovestitol were observed on the chemotaxis of neutrophils in vitro. As for chronic inflammation, neovestitol also reduced the clinical score and joint damage in a collagen-induced arthritis model. There was no change in the frequency of IL-17-producing TCD4+ cells. In addition, pretreatment with neovestitol reduced the levels of IL-6. These results demonstrate a potential anti-inflammatory activity of neovestitol, which may be useful for therapeutic purposes and/or as a nutraceutical.

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Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

Cited by 121 publications

References 53 publications

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6

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