“…The preparation of a pro duct for clinical use was reported in 1957 by Kekwick and Wolf [19], and in a slightly modified form by Holman and Wolf [13], diethyl ether being used as the protein precipitant rather than ethanol ; the successful clinical use of this fraction in the treatment of haemor rhage and the cover of dental extraction has been reported by May-cock et al [22]. Blombäck [2], in 1958, described the preparation, using ethanol, of a Fraction I-O, derived from Cohn Fraction I, which gave a good recovery of Factor VIII and was effective in the treatment of haemophilia [26].…”