Fungal keratitis caused by Macrophomina phaseolina – A case report

Premamalini, Thayanidhi; Ambujavalli, B. T.; Vijayakumar, Rajendran; Rajyoganandh, S.V.; Kalpana, S.; Kindo, Anupma Jyoti

doi:10.1016/j.mmcr.2012.10.007

Cited by 19 publications

(9 citation statements)

References 8 publications

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“…Macrophomina phaseolina, the causal agent of several plant diseases such as charcoal rot, is a threat for eucalypt crops, resulting in economic losses due to the negative effects on plant physiology [14,15]. Several clinical reports have also established this fungus as an opportunist human pathogen that causes infection in immunocompromised individuals [21,[32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites Produced by Macrophomina phaseolina Isolated from Eucalyptus globulus

et al. 2020

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In the course of investigations on the role of secondary metabolites in plant-microbe interactions, the production of secondary metabolites by Macrophomina phaseolina isolates from Eucalyptus globulus, was studied. This fungus is responsible for several plant diseases which affect crop productivity and industry. Although secondary metabolites may play a role in disease development, there are very few reports on M. phaseolina metabolomics and, as far as we know, isolates from eucalypts have not been investigated for secondary metabolites production. In the present paper, metabolites typical of fungi, from the family Botryosphaeriaceae, were identified for the first time as products of M. phaseolina. Furthermore, the isolate under examination was grown in the presence and absence of host stem tissue, and metabolite profiles were compared. Five products are reported for the first time in this species and azelaic acid was exclusively produced in the presence of eucalypt stem. Finally, phytotoxicity and cytotoxicity tests of culture filtrates and crude organic extracts were also performed. Key Contribution: Lipophilic metabolites produced by M. phaseolina might play a role in the plant-fungus interactions responsible for serious diseases of E. globulus.

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Section: Discussionmentioning

confidence: 99%

Secondary Metabolites Produced by Macrophomina phaseolina Isolated from Eucalyptus globulus

et al. 2020

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“…Infected plant debris in soil gives microsclerotia a survival home (Holliday, 1995). Sclerotia can bear a temperature above 30 o C in dry soil and under wet conditions mycelium hardly survives over 7 days and the sclerotia survival period is not exceeded over 2 months (Premamalinia et al, 2012). Adaptation of M. phaseolina to a broad range of osmotic and pH is due to the higher content of a distinct set of carbohydrate esterases (Islam et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

ANTIFUNGAL POTENTIAL OF A BRASSICACEOUS WEED Sisymbrium irio AGAINST Macrophomina phaseolina

2017

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-Macrophomina phaseolina, a soil-borne plant pathogen, has the ability to cause diseases in about 500 plant species. Unfortunately, so far no registered fungicide is available against this fungal pathogen. In the present study, different extracts of Sisymbrium irio, a weed of family Brassicaceae, were tested for evaluation of their antifungal activity against M. phaseolina. In screening bioassays, antifungal activity of methanolic extracts of 1% to 6% concentrations of different parts (leaf, stem, root and fruit) of the weed was assessed against the fungal pathogen. Methanolic leaf and root extracts significantly reduced fungal biomass up to 59% and 69% over control, respectively. Methanolic leaf and root extracts were further partitioned using four organic solvents namely n-hexane, chloroform, ethyl acetate and n-butanol in order of increasing polarity. Antifungal activity of different concentrations of these fractions (3.125, 6.25, …, 200 mg mL -1 ) was assessed against the pathogen. Chloroform and n-hexane fractions of methanolic leaf extract showed highly pronounced activity resulting in 35-75% and 15-87% reduction in fungal biomass over corresponding control treatments, respectively. Likewise, the highest concentration (200 mg mL -1 ) of chloroform, ethyl acetate and n-butanol fractions of methanolic root extract reduced fungal biomass by 75%, 70% and 87%, respectively. The present study concludes that chloroform and n-butanol fractions of methanolic leaf and root extracts of S. irio, respectively, contain potent antifungal constituents for management of M. phaseolina.Keywords: antifungal activity, London rocket, plant extracts. (3,125, 6,25, …, 200 RESUMO -

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“…Ramichloridium , Pseudozyma , Rhodotorula , and Sporobolomyces cause hematomycosis (Arendrup et al, 2014; Etienne et al, 2016). Macrophomina (Premamalini et al, 2012), Thermomyces (Sivagnanam et al, 2013), Engyodontium alum (Augustinsky et al, 1990; Thamke et al, 2015; Wu et al, 2016) can induce different types of inflammatory diseases, such as keratitis and endocarditis. Cladophialophora , Chaetomium , Curvularia , Alternaria , and Ramichloridium are not only pathogens but also cause allergic reactions in humans (McAleer et al, 1981; Cruz et al, 1997; Paredes et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Disease and Season to Hepatopancreas and Intestinal Mycobiota of Litopenaeus vannamei

Li¹,

Jiang²,

Li³

et al. 2019

Front. Microbiol.

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Increasing evidence has manifested that the gut bacterial microbiota of shrimps is closely related to the environmental factors, host developmental stage and health status like that of humans and animals does. These studies have provided an important guidance for improving shrimp culture benefits. In practice, aside from bacteria, eukaryotic microorganisms dominated by fungal microbiota (mycobiota), also play a key role in host growth, metabolism and homeostasis. However, little so far is known about the mycobiota in the digestive tract of shrimp. In this study, we used high-throughput sequencing of internal transcribed spacer 1 region to characterize the hepatopancreas and intestinal mycobiota of Pacific white shrimp and their connections with disease incidence and seasonal variation. The results showed that the hepatopancreas and intestinal mycobiota of Litopenaeus vannamei are dominated by the phyla Ascomycota and Basidiomycota, and the genera Alternaria , Tuber , Hortaea , Sarocladium , and Stagonospora . The fungal microbiota significantly varies under the influence of disease and seasonal variation. Sick shrimps had a higher level of potential pathogenic fungus, Candida in the intestine. Healthy shrimps had a higher abundance of the genera Didymella and Filobasidium in the gut, and Pyrenochaetopsis in the hepatopancreas. Of note, most of the fungi carried by Pacific white shrimps were pathogens to humans. This study has revealed the intestinal and hepatopancreas mycobiota of L. vannamei and the effects of diseases and seasonal variation to the mycobiota. Our study provides important guidance for Pacific white shrimp farming and sheds further insight on the fungal microbiota.

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Fungal keratitis caused by Macrophomina phaseolina – A case report

Cited by 19 publications

References 8 publications

Secondary Metabolites Produced by Macrophomina phaseolina Isolated from Eucalyptus globulus

Secondary Metabolites Produced by Macrophomina phaseolina Isolated from Eucalyptus globulus

ANTIFUNGAL POTENTIAL OF A BRASSICACEOUS WEED Sisymbrium irio AGAINST Macrophomina phaseolina

The Effect of Disease and Season to Hepatopancreas and Intestinal Mycobiota of Litopenaeus vannamei

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